Repetitive traumatic brain injury, psychological symptoms, and suicide risk in a clinical sample of deployed military personnel
Abstract
Importance Traumatic brain injury (TBI) is believed to be one factor contributing to rising suicide rates among military personnel and veterans. This study investigated the association of cumulative TBIs with suicide risk in a clinical sample of deployed military personnel referred for a TBI evaluation. Objective To determine whether suicide risk is more frequent and heightened among military personnel with multiple lifetime TBIs than among those with no TBIs or a single TBI. Design Patients completed standardized self-report measures of depression, posttraumatic stress disorder (PTSD), and suicidal thoughts and behaviors; clinical interview; and physical examination. Group comparisons of symptom scores according to number of lifetime TBIs were made, and generalized regression analyses were used to determine the association of cumulative TBIs with suicide risk. Participants Patients included 161 military personnel referred for evaluation and treatment of suspected head injury at a military hospital's TBI clinic in Iraq. Main outcomes and measures Behavioral Health Measure depression subscale, PTSD Checklist-Military Version, concussion symptoms, and Suicide Behaviors Questionnaire-Revised. Results Depression, PTSD, and TBI symptom severity significantly increased with the number of TBIs. An increased incidence of lifetime suicidal thoughts or behaviors was associated with the number of TBIs (no TBIs, 0%; single TBI, 6.9%; and multiple TBIs, 21.7%; P = .009), as was suicidal i…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Current or former service members who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality following injury compared to non-injured peers.
“Military service members (SMs) and veterans who have sustained one or more concussions during their service have significantly higher rates of persistent depressive symptoms and suicidality compared to non-injured peers.”
Between 16% and 20% of all operations Enduring Freedom, Iraqi Freedom, and New Dawn veterans have a history of mTBI, and among them, up to 22% report suicidal ideation.
“Overall, between 16% and 20% of all operations Enduring Freedom, Iraqi Freedom, and New Dawn veterans have a history of mTBI, and among them, up to 22% report suicidal ideation (SI) [4].”
Cites
Osman, A., Bagge, C. L., Gutierrez, P. M., Konick, L. C., Kopper, B. A., & Barrios, F. X. (2001) · Assessment · doi:10.1177/107319110100800409 · Cited by 2,276 · see citing works
Toward a clinical model of suicidal behavior in psychiatric patients
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.181 · Cited by 1,791 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mental Health Consequences of Traumatic Brain Injury
Howlett, J. R., Nelson, L. D., & Stein, M. B. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.09.024 · Cited by 389 · see citing works
Quantitative forecasting of PTSD from early trauma responses: A Machine Learning application
Galatzer-Levy, I. R., Karstoft, K.-I., Statnikov, A., & Shalev, A. Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.017 · Cited by 195 · see citing works
Fazel, S., Wolf, A., Pillas, D., Lichtenstein, P., & Långström, N. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3935 · Cited by 159 · see citing works
Stein, M. B., Kessler, R. C., Heeringa, S. G., Jain, S., Campbell-Sills, L., Colpe, L. J., Fullerton, C. S., Nock, M. K., Sampson, N. A., Schoenbaum, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14121572 · Cited by 161 · see citing works
Russo, M. V., Latour, L. L., & McGavern, D. B. (2018) · Nature Immunology · doi:10.1038/s41590-018-0086-2 · Cited by 149 · see citing works
Spira, J. L., Lathan, C. E., Bleiberg, J., & Tsao, J. W. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3363 · Cited by 79 · see citing works
McIntire, K. L., Crawford, K. M., Perrin, P. B., Sestak, J. L., Aman, K., Walter, L. A., Page, D. B., Wen, H., Randolph, B. O., Brunner, R. C., et al. (2021) · Brain Injury · doi:10.1080/02699052.2020.1861656 · Cited by 51 · see citing works
Flores-Sandoval, C., Teasell, R., MacKenzie, H. M., McIntyre, A., Barua, U., Mehta, S., Bayley, M., & Bateman, E. A. (2024) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000984 · Cited by 16 · see citing works
Bernanke, A., Hasley, R., Sabetfakhri, N., de Wit, H., Smith, B. M., Wang, L., Brenner, L. A., Hanlon, C., Philip, N. S., Ajilore, O., et al. (2024) · JMIR Research Protocols · doi:10.2196/58206 · Cited by 2 · see citing works
Oberman, L. M., Penafiel, A. I., Dieterich, R., Phan, C. T., Chou, Y.-Y., Pham, D. L., Adamson, M. M., Hines, C. E., Rezaee, Z., Deng, Z.-D., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1605157
- Authors
- Bryan, C. J., & Clemans, T. A.
- Affiliations
- VA Rocky Mountain Network (US)
- Corresponding author
- Bryan, Craig J.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2013-07-01
- Volume
- 70
- Issue
- 7
- Pages
- 686
- ISSN
- 2168-622X (ISSN-L)
- OpenAlex
- W2128690563
- Cited by
- 195
- References
- 2
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 16 · 2019: 17 · 2018: 15 · 2017: 19 · 2016: 15 · 2015: 25 · 2014: 23 · 2013: 6
- FWCI
- 16.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- repetitive traumatic brain injury, suicide risk, suicidal ideation, military personnel, depression, post-traumatic stress disorder, deployed troops, concussion symptoms, suicide risk factors
- MeSH terms
- Adult, Brain Injuries, Depression, Female, Humans, Male, Military Personnel, Risk Factors, Stress Disorders, Post-Traumatic, Suicide, Iraq War, 2003-2011, Suicidal Ideation, Symptom Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review