Cited by 214Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study

Open access

Pietrzak, Robert H., Lim, Yen Ying, Neumeister, Alexander, Ames, David, Ellis, Kathryn A., Harrington, Karra, Lautenschlager, Nicola T., Restrepo, Carolina, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L., Rowe, Christopher C., Maruff, Paul·2015·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2014.2476

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Alzheimer disease (AD) is now known to have a long preclinical phase in which pathophysiologic processes develop many years, even decades, before the onset of clinical symptoms. Although the presence of abnormal levels of amyloid-β (Aβ) is associated with higher rates of progression to clinically classified mild cognitive impairment or dementia, little research has evaluated potentially modifiable moderators of Aβ-related cognitive decline, such as anxiety and depressive symptoms. OBJECTIVE: To evaluate the association between Aβ status and cognitive changes, and the role of anxiety and depressive symptoms in moderating Aβ-related cognitive changes in the preclinical phase of AD. DESIGN, SETTING, AND PARTICIPANTS: In this multicenter, prospective cohort study with baseline and 18-, 36-, and 54-month follow-up assessments, we studied 333 healthy, older adults at hospital-based research clinics. MAIN OUTCOMES AND MEASURES: Carbon 11-labeled Pittsburgh Compound B (PiB)-, florbetapir F 18-, or flutemetamol F 18-derived measures of Aβ, Hospital Anxiety and Depression Scale scores, and comprehensive neuropsychological evaluation that yielded measures of global cognition, verbal memory, visual memory, attention, language, executive function, and visuospatial ability. RESULTS: A positive Aβ (Aβ+) status at baseline was associated with a significant decline in global cognition, verbal memory, language, and executive function, and elevated anxiety symptoms moderated these associations. Compared with the Aβ+, low-anxiety group, slopes of cognitive decline were significantly more pronounced in the Aβ+, high-anxiety group, with Cohen d values of 0.78 (95% CI, 0.33-1.23) for global cognition, 0.54 (95% CI, 0.10-0.98) for verbal memory, 0.51 (95% CI, 0.07-0.96) for language, and 0.39 (95% CI, 0.05-0.83) for executive function. These effects were independent of age, educational level, IQ, APOE genotype, subjective memory complaints, vascular risk factors, and depressive symptoms; furthermore, depressive symptoms and subjective memory complaints did not moderate the association between Aβ and cognitive decline. CONCLUSIONS AND RELEVANCE: These results provide additional support for the deleterious effect of elevated Aβ levels on cognitive function in preclinical AD. They further suggest that elevated anxiety symptoms moderate the effect of Aβ on cognitive decline in preclinical AD, resulting in more rapid decline in several cognitive domains. Given that there is currently no standard antiamyloid therapy and that anxiety symptoms are amenable to treatment, these findings may help inform risk stratification and management of the preclinical phase of AD.

Integrity signals

Registry

Crossref · 10.1001/jamapsychiatry.2014.2476

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779
Anxiety and cognitive performance: Attentional control theory
Eysenck, M. W., Derakshan, N., Santos, R., & Calvo, M. G. (2007) · Emotion · doi:10.1037/1528-3542.7.2.336 · Cited by 5,289
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279
Self-citation
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200
Use of Florbetapir-PET for Imaging β-Amyloid Pathology
Clark, C. M. (2011) · JAMA · doi:10.1001/jama.2010.2008 · Cited by 1,117
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
Ellis, K. A., Bush, A. I., Darby, D., Fazio, D. D., Foster, J. K., Hudson, P. J., Lautenschlager, N. T., Lenzo, N. P., Martins, R. N., Maruff, P. T., et al. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209009405 · Cited by 1,005
Self-citation
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
Rowe, C. C., Ellis, K. A., Rimajova, M., Bourgeat, P., Pike, K. E., Jones, G., Fripp, J., Tochon-Danguy, H., Morandeau, L., O'Keefe, G., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.007 · Cited by 986
Self-citation
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686
18 F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial
Vandenberghe, R. R., Laere, K. V., Ivanoiu, A., Salmon, É., Bastin, C., Triau, E., Hasselbalch, S. G., Law, I. G., Andersen, A., Kørner, A., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22068 · Cited by 664
Assessment of Memory Complaint in Age-Associated Memory Impairment: The MAC-Q
Crook, T. H., Feher, E. P., & Larrabee, G. J. (1992) · International Psychogeriatrics · doi:10.1017/s1041610292000991 · Cited by 434

Show all 51 references

Sorted by citations

Subjective Cognitive Decline in Preclinical Alzheimer's Disease
Rabin, L. A., Smart, C. M., & Amariglio, R. E. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045136 · Cited by 590
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Luo, R., Su, L.-Y., Li, G., Yang, J., Liu, Q., Yang, L.-X., Zhang, D.-F., Zhou, H., Xu, M., Fan, Y., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1596488 · Cited by 364
Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis
Liu, Q., Xi, Y., Wang, Q., Liu, J., Li, P., Meng, X., Liu, K., Chen, W., Liu, X., & Liu, Z. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.04.005 · Cited by 241
Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer’s disease: a systematic review of symptom-general and –specific lesion patterns
Chen, Y., Dang, M., & Zhang, Z. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00456-1 · Cited by 238
Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility
Mortamais, M., Ash, J. A., Harrison, J., Kaye, J. A., Kramer, J. H., RANDOLPH, C. C., Pose, C., Albala, B., Ropacki, M. T., Ritchie, C. W., et al. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.2365 · Cited by 212
Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates
Perrotin, A., La Joie, R., de La Sayette, V., Barré, L., Mézenge, F., Mutlu, J., Guilloteau, D., Egret, S., Eustache, F., & Chételat, G. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.011 · Cited by 179
Apathy and anxiety are early markers of Alzheimer's disease
Johansson, M., Stomrud, E., Lindberg, O. E., Westman, E., Johansson, P., van Westen, D., Mattsson, N., & Hansson, O. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.008 · Cited by 192
Anxiety and cognition
Maloney, E. A., Sattizahn, J. R., & Beilock, S. L. (2014) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1299 · Cited by 179
Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect
Pi, G., Gao, D., Wu, D., Wang, Y., Lei, H., Zeng, W., Gao, Y., Yu, H., Xiong, R., Jiang, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13919-3 · Cited by 158
The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable
Knopman, D. S., Haeberlein, S. B., Carrillo, M. C., Hendrix, J. A., Kerchner, G., Margolin, R. A., Maruff, P. T., Miller, D. S., Tong, G., Tome, M. B., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.03.002 · Cited by 144
Self-citation
The Relationship Between Anxiety and Alzheimer’s Disease
Mendez, M. F. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-210294 · Cited by 156
High depression and anxiety in people with Alzheimer's disease living in retirement homes during the covid-19 crisis
Haj, M. E., Altıntaş, E., Chapelet, G., Kapogiannis, D., & Gallouj, K. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113294 · Cited by 138
Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results
Slot, R. E. R., Verfaillie, S. C. J., Overbeek, J. M., Timmers, T., Wesselman, L. M. P., Teunissen, C. E., Dols, A., Bouwman, F. H., Prins, N. D., Barkhof, F., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0390-y · Cited by 131
Support for midlife anxiety diagnosis as an independent risk factor for dementia: a systematic review
Gimson, A., Schlosser, M., Huntley, J. D., & Marchant, N. L. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019399 · Cited by 137
Anxiety Disorders in the Elderly
Andreescu, C., & Lee, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9705-0_28 · Cited by 134
Baseline prevalence and longitudinal evolution of non-motor symptoms in early Parkinson’s disease: the PPMI cohort
Simuni, T., Caspell‐Garcia, C., Coffey, C. S., Weintraub, D. A., Mollenhauer, B., Lasch, S., Tanner, C. M., Jennings, D. L., Kieburtz, K. D., Chahine, L. M., et al. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-316213 · Cited by 119
Chronic stress and Alzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia
Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., Jackaman, C., Villemagne, V., Munyard, K., Laws, S. M., Verdile, G., et al. (2021) · Biological Reviews · doi:10.1111/brv.12750 · Cited by 116
Self-citation
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
Hoffman, J. L., Faccidomo, S., Kim, M., Taylor, S. M., Agoglia, A. E., May, A. M., Smith, E. N., Wong, L. C., & Hodge, C. W. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.10.017 · Cited by 113
Repetitive negative thinking is associated with amyloid, tau, and cognitive decline
Marchant, N. L., Lovland, L. R., Jones, R., Binette, A. P., Gonneaud, J., Arenaza‐Urquijo, E. M., Chételat, G., & Villeneuve, S. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12116 · Cited by 115
Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort
Matušková, V., Ismail, Z., Nikolai, T., Marková, H., Čechová, K., Nedelská, Z., Laczó, J., Wang, M., Hort, J., & Vyhnálek, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.643271 · Cited by 109
Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis
Salinaro, A. T., Siracusa, R., Paola, R. D., Scuto, M. C., Ontario, M. L., Bua, R. O., Mauro, P. D., Toscano, M. A., Petralia, C. C. T., Maiolino, L., et al. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0078-8 · Cited by 100
Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment
Grill, J. D., Raman, R., Ernstrom, K. B., Sultzer, D. L., Burns, J. M., Donohue, M., Johnson, K. A., Aisen, P. S. S., Sperling, R. A., Karlawish, J. H., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2734 · Cited by 101
Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults
Guo, T., Landau, S. M., Jagust, W. J., & Initiative, A. D. N. (2020) · Neurology · doi:10.1212/wnl.0000000000009216 · Cited by 92
Psychosocial risk factors and Alzheimer's disease: the associative effect of depression, sleep disturbance, and anxiety
Burke, S. L., Cadet, T. J., Alcide, A., O’Driscoll, J., & Maramaldi, P. (2017) · Aging & Mental Health · doi:10.1080/13607863.2017.1387760 · Cited by 100
Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression
Perna, G., Iannone, G., Alciati, A., & Caldirola, D. (2015) · Neural Plasticity · doi:10.1155/2016/8457612 · Cited by 100
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models
Huang, Y., Skwarek‐Maruszewska, A., Horré, K., Vandewyer, E., Wolfs, L., Snellinx, A., Saito, T., Radaelli, E., Corthout, N., Colombelli, J., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3492 · Cited by 92
New Research on Anxiety Disorders in the Elderly and an Update on Evidence-Based Treatments
Andreescu, C., & Varon, D. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0595-8 · Cited by 85
A Systematic Review of Longitudinal Studies Which Measure Alzheimer’s Disease Biomarkers
Lawrence, E., Vegvari, C., Ower, A. K., Hadjichrysanthou, C., de Wolf, F., & Anderson, R. M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170261 · Cited by 89
Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia
Ettcheto, M., Olloquequi, J., Sánchez‐López, E., Busquets, O., Cano, A. C., Manzine, P. R., Beas‐Zárate, C., Castro-Torres, R. D., García, M. L., Bulló, M., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00344 · Cited by 83
Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 84
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease
Esmaeili, M. H., Bahari, B., & Salari, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.01.001 · Cited by 81
Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging
Krell‐Roesch, J., Lowe, V. J., Neureiter, J., Pink, A., Roberts, R. O., Mielke, M. M., Vemuri, P., Stokin, G. B., Christianson, T. J. H., Jack, C. R., et al. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217002368 · Cited by 81
Do Older Adults Need Sleep? A Review of Neuroimaging, Sleep, and Aging Studies
Scullin, M. K. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0086-z · Cited by 88
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Pradeepkiran, J. A., Baig, J., Islam, M. A., Kshirsagar, S., & Reddy, P. H. (2024) · Aging and Disease · doi:10.14336/ad.2024.0286 · Cited by 87
Anxiety and risk of dementia: Systematic review and meta-analysis of prospective cohort studies
Santabárbara, J., Lipnicki, D. M., Villagrasa, B., Lobo, E., & López‐Antón, R. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.10.014 · Cited by 85
Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice
Zhang, H., Su, Y., Sun, Z., Chen, M., Han, Y., Li, Y., Dong, X., Ding, S., Fang, Z., Li, W., et al. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.003 · Cited by 76
Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer's disease pathogenesis
Salinaro, A. T., Siracusa, R., Paola, R. D., Scuto, M. C., Fronte, V., Koverech, G., Luca, M., Serra, A., Toscano, M. A., Petralia, A., et al. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.09.012 · Cited by 75
The association of anxiety, depression, and worry symptoms on cognitive performance in older adults
Vito, A. N. D., Calamia, M. R., Greening, S. G., & Roye, S. (2017) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2017.1416057 · Cited by 76
Aging faster: worry and rumination in late life are associated with greater brain age
Karim, H. T., Ly, M. J., Yu, G. Z., Krafty, R. T., Tudorascu, D., Aizenstein, H. J., & Andreescu, C. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.009 · Cited by 76
Development of Apathy, Anxiety, and Depression in Cognitively Unimpaired Older Adults: Effects of Alzheimer’s Disease Pathology and Cognitive Decline
Johansson, M., Stomrud, E., Johansson, P., Svenningsson, A., Palmqvist, S., Janelidze, S., van Westen, D., Mattsson, N., & Hansson, O. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.012 · Cited by 77
Anxiety as a Risk Factor for Cognitive Decline: A 12-Year Follow-Up Cohort Study
Gulpers, B. J. A., Oude Voshaar, R. C., van Boxtel, M. P. J., Verhey, F. R. J., & Köhler, S. (2019) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.09.006 · Cited by 68
The impact of anxiety on the progression of mild cognitive impairment to dementia in Chinese and English data bases: a systematic review and meta‐analysis
Li, X., & Li, Z. (2017) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4694 · Cited by 69
Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study
Goukasian, N., Hwang, K. S., Romero, T., Grotts, J., Do, T. M., Groh, J. R., Bateman, D. R., & Apostolova, L. G. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-031947 · Cited by 64
Plasma Cortisol, Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study
Pietrzak, R. H., Laws, S. M., Lim, Y. Y., Bender, S. J., Porter, T., Doecke, J. D., Ames, D. J., Fowler, C. J., Masters, C. L., Milicic, L., et al. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.08.006 · Cited by 64
Self-citation
A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress
Hoeijmakers, L., Lesuis, S. L., Krugers, H. J., Lucassen, P. J., & Kőrösi, A. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.02.003 · Cited by 66
NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease
Amani, M., Zolghadrnasab, M., & Salari, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.01.005 · Cited by 62
Imaging β-amyloid using [18F]flutemetamol positron emission tomography: from dosimetry to clinical diagnosis
Heurling, K., Leuzy, A., Zimmer, E. R., Lubberink, M., & Nordberg, A. K. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3208-1 · Cited by 59
A Mediterranean diet supplemented with dairy foods improves mood and processing speed in an Australian sample: results from the MedDairy randomized controlled trial
Wade, A. T., Davis, C. R., Dyer, K. A., Hodgson, J. M., Woodman, R. J., Keage, H. A. D., & Murphy, K. J. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1543148 · Cited by 57
Anxiety adds the risk of cognitive progression and is associated with axon/synapse degeneration among cognitively unimpaired older adults
Sun, L., Li, W., Qiu, Q., Hu, Y., Yang, Z., & Xiao, S. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104703 · Cited by 64
Impact of Personality on Cognitive Aging: A Prospective Cohort Study
Caselli, R. J., Dueck, A. C., Locke, D. E. C., Henslin, B. R., Johnson, T. A., Woodruff, B. K., Hoffman‐Snyder, C., & Geda, Y. E. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000527 · Cited by 59
Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer’s disease
Yang, J., Kou, J., Lalonde, R., & Fukuchi, K.-I. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.012 · Cited by 57
Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time
Kuhn, E., Moulinet, I., Perrotin, A., La Joie, R., Landeau, B., Tomadesso, C., Bejanin, A., Sherif, S., De La Sayette, V., Desgranges, B., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0514-z · Cited by 51
Updating the evidence for an association between anxiety and risk of Alzheimer's disease: A meta-analysis of prospective cohort studies.
Santabárbara, J., Lipnicki, D. M., Bueno‐Notivol, J., Olaya, B., Villagrasa, B., & López‐Antón, R. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.065 · Cited by 58
Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological State
Martorana, A., Lorenzo, F. D., Belli, L., Sancesario, G., Toniolo, S., Sallustio, F., Sancesario, G. M., & Koch, G. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12476 · Cited by 51
Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder
Alhusaini, M., Eissa, N., Saad, A. K., Beiram, R., & Sadek, B. S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.861094 · Cited by 51
Activity of Selected Group of Monoterpenes in Alzheimer’s Disease Symptoms in Experimental Model Studies—A Non-Systematic Review
Wojtunik‐Kulesza, K. A., Rudkowska, M., Kasprzak‐Drozd, K., Oniszczuk, A., & Borowicz, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147366 · Cited by 51
The impacts of a GO-game (Chinese chess) intervention on Alzheimer disease in a Northeast Chinese population
Lin, Q., Cao, Y., & Gao, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00163 · Cited by 47
Clinically relevant anxiety and risk of Alzheimer's disease in an elderly community sample: 4.5 years of follow-up.
Santabárbara, J., Villagrasa, B., López‐Antón, R., Olaya, B., Bueno‐Notivol, J., de la Cámara, C., Gracia‐García, P., Lobo, E., & Lobo, A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.050 · Cited by 47
Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study
Kemppainen, N. M., Johansson, J. J., Teuho, J., Parkkola, R. K., Joutsa, J., Ngandu, T., Solomon, A., Stephen, R., Liu, Y., Hänninen, T., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004827 · Cited by 47
Temporal dynamics of cognitive performance and anxiety across older adulthood.
Petkus, A. J., Reynolds, C. A., Wetherell, J. L., Kremen, W. S., & Gatz, M. (2017) · Psychology and Aging · doi:10.1037/pag0000164 · Cited by 46
What’s That (Blue) Spot on my MRI? Multimodal Neuroimaging of the Locus Coeruleus in Neurodegenerative Disease
Kelberman, M. A., Keilholz, S. D., & Weinshenker, D. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583421 · Cited by 46
A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment
Pink, A., Krell‐Roesch, J., Syrjanen, J. A., Vassilaki, M. E., Lowe, V. J., Vemuri, P., Stokin, G. B., Christianson, T. J. H., Kremers, W. K., Jack, C. R., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12504 · Cited by 45
Depressive Symptoms are Associated with Progression to Dementia in Patients with Amyloid-Positive Mild Cognitive Impairment
Moon, B., Kim, S., Park, Y. H., Lim, J., Youn, Y. C., Kim, S., Jang, J., & Initiative, A. D. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170225 · Cited by 44
Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours
Pervolaraki, E., Hall, S. P., Foresteire, D., Saito, T., Saido, T. C., Whittington, M. A., Lever, C., & Dachtler, J. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040550 · Cited by 42
Stress and Alzheimer’s disease
Escher, C. M., Sannemann, L., & Jessen, F. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01988-z · Cited by 47
Neuroprotective effect of alpha‐pinene is mediated by suppression of the TNF‐α/NF‐κB pathway in Alzheimer's disease rat model
Khan‐Mohammadi‐Khorrami, M., Asle‐Rousta, M., Rahnema, M., & Amini, R. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23006 · Cited by 42
The SCD‐Well randomized controlled trial: Effects of a mindfulness‐based intervention versus health education on mental health in patients with subjective cognitive decline (SCD)
Marchant, N. L., Barnhofer, T., Klimecki, O. M., Poisnel, G., Lutz, A., Arenaza‐Urquijo, E., Collette, F., Wirth, M., Schild, A., Coll‐Padrós, N., et al. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.10.010 · Cited by 38
Amyloid‐associated depression and ApoE4 allele: longitudinal follow‐up for the development of Alzheimer's disease
Qiu, W. Q., Zhu, H., Dean, M., Liu, Z., Vu, L., Fan, G., Li, H., Mwamburi, M., Steffens, D. C., & Au, R. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4339 · Cited by 41
Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice
Li, Z., Bi, H. C., Jiang, H., Song, J., Meng, Q., Zhang, Y., & Fei, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11747 · Cited by 40
Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer’s Disease
Kelberman, M. A., Anderson, C. R., Chlan, E., Rorabaugh, J. M., McCann, K. E., & Weinshenker, D. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215546 · Cited by 42
G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model
Huang, Y., Guimarães, T. R., Todd, N., Ferguson, C., Weiss, K. M., Stauffer, F., McDermott, B., Hurtle, B. T., Saito, T., Saido, T. C., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204828119 · Cited by 37
Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model
Pupyshev, A. B., Беличенко, В. М., Tenditnik, M. V., Bashirzade, A. A., Dubrovina, N. I., Ovsyukova, M. V., Akopyan, A. A., Fedoseeva, L. A., Короленко, Т. А., Amstislavskaya, T. G., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173406 · Cited by 38
Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults
Jang, J. Y., Ho, J. K., Blanken, A. E., Dutt, S., Nation, D. A., & Initiative, T. A. D. N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200190 · Cited by 39
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice
Li, H., Zhao, J., Lai, L., Xia, Y., Wan, C., Wei, S., Liang, J., Chen, Y., & Xu, N. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.05.013 · Cited by 34
Enriched endogenous n-3 polyunsaturated fatty acids alleviate cognitive and behavioral deficits in a mice model of Alzheimer’s disease
Wu, K., Gao, X., Shi, B., Chen, S., Zhou, X., Li, Z., Gan, Y., Cui, L., Kang, J. X., Li, W., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.038 · Cited by 34
Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones
Wu, Y., Hang, Z., Tong, L., & Du, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03784-w · Cited by 34
Administering crocin ameliorates anxiety‐like behaviours and reduces the inflammatory response in amyloid‐beta induced neurotoxicity in rat
Hadipour, M., Bahari, Z., Afarinesh, M. R., Jangravi, Z., Shirvani, H., & Meftahi, G. H. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13494 · Cited by 33
Childhood Secondhand Smoke Exposure and Risk of Dementia, Alzheimer's Disease and Stroke in Adulthood: A Prospective Cohort Study
Zhou, S., & Wang, K. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2021.10 · Cited by 36
Association Between Psychological Distress and Incident Dementia in a Population-Based Cohort in Finland
Sulkava, S., Haukka, J. K., Sulkava, R. O., Laatikainen, T. K., & Paunio, T. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.47115 · Cited by 34
Moderating risk of Alzheimer's disease through the use of anxiolytic agents
Burke, S. L., O’Driscoll, J., Alcide, A., & Li, T. (2016) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4614 · Cited by 30
Lifetime affective problems and later-life cognitive state: Over 50 years of follow-up in a British birth cohort study
James, S., Davis, D. H. J., O’Hare, C., Sharma, N., John, A., Gaysina, D., Hardy, R., Kuh, D. J., & Richards, M. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.078 · Cited by 34
Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5
Aminyavari, S., Zahmatkesh, M., Khodagholi, F., & Sanati, M. (2019) · Peptides · doi:10.1016/j.peptides.2019.170102 · Cited by 31
Natriuretic peptides in the central nervous system: Novel targets for cognitive impairment
Mahinrad, S., de Craen, A. J. M., Yaşar, S., van Heemst, D., & Sabayan, B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.022 · Cited by 30
Trait Mindfulness Is Associated With Less Amyloid, Tau, and Cognitive Decline in Individuals at Risk for Alzheimer’s Disease
Strikwerda‐Brown, C., Ozlen, H., Binette, A. P., Chapleau, M., Marchant, N. L., Breitner, J. C. S., & Villeneuve, S. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.01.001 · Cited by 31
Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease
Dang, M., Chen, Q., Zhao, X. B., Chen, K., Li, X., Zhang, J., Lu, J., Ai, L., Chen, Y., & Zhang, Z. (2022) · Human Brain Mapping · doi:10.1002/hbm.26043 · Cited by 31
How Do Modifiable Risk Factors Affect Alzheimer’s Disease Pathology or Mitigate Its Effect on Clinical Symptom Expression?
Ourry, V., Binette, A. P., St‐Onge, F., Strikwerda‐Brown, C., Chagnot, A., Poirier, J., Breitner, J. C. S., Arenaza‐Urquijo, E. M., Rabin, J. S., Buckley, R. F., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.003 · Cited by 30
A Remote Intervention to Prevent or Delay Cognitive Impairment in Older Adults: Design, Recruitment, and Baseline Characteristics of the Virtual Cognitive Health (VC Health) Study
Bott, N. T., Kumar, S., Krebs, C., Glenn, J. M., Madero, E. N., & Juusola, J. L. (2018) · JMIR Research Protocols · doi:10.2196/11368 · Cited by 32
Disclosure of Amyloid Status for Risk of Alzheimer Disease to Cognitively Normal Research Participants With Subjective Cognitive Decline: A Longitudinal Study
Wake, T., Tabuchi, H., Funaki, K., Ito, D., Yamagata, B., Yoshizaki, T., Nakahara, T., Jinzaki, M., Yoshimasu, H., Tanahashi, I., et al. (2020) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317520904551 · Cited by 30
The long-term consequences of repetitive head impacts: Chronic traumatic encephalopathy
Alosco, M. L., & Stern, R. A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00018-2 · Cited by 28
Repurposing psychiatric medicines to target activated microglia in anxious mild cognitive impairment and early Parkinson's disease.
Lauterbach, E. C. (2016) · Europe PMC (PubMed Central) · Cited by 27
Psychotherapeutic interventions in individuals at risk for Alzheimer’s dementia: a systematic review
Rostamzadeh, A., Kahlert, A., Kalthegener, F., & Jessen, F. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00956-8 · Cited by 26
Sex hormones, vascular factors and cognition
Szoeke, C. E. I., Downie, S., Parker, A. F., & Phillips, S. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100927 · Cited by 26
Elucidating the association between depression, anxiety, and cognition in middle-aged adults: Application of dimensional and categorical approaches
Perin, S., Lai, J., Pase, M. P., Bransby, L., Buckley, R. F., Yassi, N., Pietrzak, R. H., Maruff, P. T., & Lim, Y. Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.007 · Cited by 27
Self-citation
Exercise interventions to reduce anxiety in mid-life and late-life anxiety disorders and subthreshold anxiety disorder: a systematic review
Chong, T. W. H., Kootar, S., Wilding, H., Berriman, S., Curran, E. M., Cox, K. L., Bahar‐Fuchs, A., Peters, R. K., Anstey, K. J., Bryant, C., et al. (2022) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253221104958 · Cited by 29
Self-citation
Anxiety and Depressive Symptoms and Cortical Amyloid-β Burden in Cognitively Unimpaired Older Adults
Lewis, C., Bernstein, O. M., Grill, J. D., Gillen, D. L., & Sultzer, D. L. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.13 · Cited by 26
Clinically significant anxiety as a risk factor for Alzheimer's disease: Results from a 10‐year follow‐up community study
Gracia‐García, P., Bueno‐Notivol, J., Lipnicki, D. M., de la Cámara, C., Lobo, A., & Santabárbara, J. (2023) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.1934 · Cited by 28
TFEB agonist clomiphene citrate activates the autophagy-lysosomal pathway and ameliorates Alzheimer's disease symptoms in mice
Lin, J. E., Yuan, Y., Huang, C., Zi, J., Li, L., Liu, J., Wu, X., Li, W., Zhao, Q. H., Li, Y., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107929 · Cited by 22
Effects of Mindfulness-based Interventions on Dementia Patients: A Meta-analysis
Wang, F. L., Tang, Q. Y., Zhang, L. L., Yang, J., Li, Y., Peng, H., & Wang, S. H. (2020) · Western Journal of Nursing Research · doi:10.1177/0193945920916750 · Cited by 23
Examining the Bidirectional Nature of Loneliness and Anxiety Among Older Adults in Daily Life
Bogart, K. V., Scott, S., Harrington, K., Felt, J. M., Sliwinski, M. J., & Graham‐Engeland, J. E. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad105 · Cited by 24
Self-citation
Clinical and striatal dopamine transporter predictors of β-amyloid in dementia with Lewy bodies
Yoo, H. S., Lee, S., Chung, S. J., Lee, Y. H., Ye, B. S., Sohn, Y. H., Yun, M., & Lee, P. H. (2020) · Neurology · doi:10.1212/wnl.0000000000009168 · Cited by 22

Authors: Pietrzak, R. H., Lim, Y. Y., Neumeister, A., Ames, D., Ellis, K. A., Harrington, K., Lautenschlager, N. T., Restrepo, C., Martins, R. N., Masters, C. L., Villemagne, V. L., Rowe, C. C., & Maruff, P.
Affiliations: United States Department of Veterans Affairs (US)
The University of Melbourne (AU)
New York University (US)
Edith Cowan University (AU)
Corresponding author: Pietrzak, Robert H.
ORCID: Pietrzak, Robert H.
Lim, Yen Ying
Ellis, Kathryn A.
Harrington, Karra
Lautenschlager, Nicola T.
Martins, Ralph N.
Masters, Colin L.
Villemagne, Victor L.
Maruff, Paul
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2015-03-01
Volume: 72
Issue: 3
Pages: 284
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2014.2476
OpenAlex: W2049932209
Cited by: 214
References: 51
Citations by year: 2026: 13 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 22 · 2021: 27 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 20 · 2016: 15 · 2015: 10
FWCI: 16.22
Type: journal article
Language: en
Open access: green
research-repository.uwa.edu.au
Licence: other-oa
Locations: JAMA Psychiatry (publishedVersion)
UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
PubMed (publishedVersion)
Australasian Journal of Paramedicine (submittedVersion)
Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: amyloid-beta, preclinical Alzheimer's disease, anxiety, cognitive decline, depressive symptoms, moderating effect, amyloid PET, Pittsburgh compound B, florbetapir, verbal memory, executive function, language, global cognition, older adults, subjective memory complaints, APOE genotype, mild cognitive impairment, dementia risk
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Depression, Female, Genotype, Humans, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Amyloid beta-Peptides, Disease Progression, Positron-Emission Tomography, Prodromal Symptoms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks