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Cited by 51Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

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Kuhn, Elizabeth, Moulinet, Inès, Perrotin, Audrey, La Joie, Renaud, Landeau, Brigitte, Tomadesso, Clémence, Bejanin, Alexandre, Sherif, Siya +5 more·2019·Alzheimer's Research & Therapy
DOI 10.1186/s13195-019-0514-zPMC PMC6615169
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Abstract

BACKGROUND: Subjective cognitive decline (SCD) defines a heterogeneous population, part of which having Alzheimer's disease (AD). We aimed at characterizing SCD populations according to whether or not they referred to a memory clinic, by assessing the factors associated with increased AD risk. METHODS: Seventy-eight cognitively unimpaired older adults from the IMAP+ study (Caen) were included, amongst which 28 healthy controls (HC) and 50 SCD recruited from the community (SCD-community; n = 23) or from a memory clinic (SCD-clinic; n = 27). Participants underwent cognitive, psychoaffective, structural MRI, FDG-PET, and amyloid-PET assessments. They were followed up over a mean period of 2.4 ± 0.8 years. The groups were compared in terms of baseline and follow-up levels of SCD (self- and informant-reported), cognition, subclinical anxiety and depression, and atrophy progression over time. We also investigated SCD substrates within each SCD group through the correlations between self-reported SCD and other psychometric and brain measures. RESULTS: Compared to HC, both SCD groups showed similar cognitive performances but higher informant-reported SCD and anxiety. Compared to SCD-community, SCD-clinic showed higher informant-reported SCD, depression score, and atrophy progression over time but similar brain amyloid load. A significant increase over time was found for depression in the SCD-community and for self-reported praxis-domestic activities SCD factor in the SCD-clinic. Higher self-reported SCD correlated with (i) lower grey matter volume and higher anxiety in SCD-community, (ii) greater informant-reported SCD in SCD-clinic, and (iii) lower glucose metabolism in both SCD groups. CONCLUSIONS: Higher subclinical depression and informant-reported SCD specifically characterize the SCD group that refers to a memory clinic. The same group appears as a frailer population than SCD-community as they show greater atrophy progression over time. Yet, both the SCD groups were quite similar otherwise including for brain amyloid load and the SCD-community showed increased depression score over time. Altogether, our findings highlight the relevance of assessing psychoaffective factors and informant-reported SCD in SCD populations and point to both differences and similarities in SCD populations referring or not to a memory clinic.

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  • Patients with subjective cognitive decline from the clinic display greater gray matter atrophy progression over time compared with patients with subjective cognitive decline from the community, indicating that clinical subjective cognitive decline may represent a greater risk of dementia due to Alzheimer's disease.

    “Specifically, patients with SCD from the clinic displayed greater gray matter atrophy progression over time compared with patients with SCD from the community, indicating that clinical SCD may represent a greater risk of dementia due to AD [192].”

    From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [192]

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Authors
Kuhn, E., Moulinet, I., Perrotin, A., La Joie, R., Landeau, B., Tomadesso, C., Bejanin, A., Sherif, S., De La Sayette, V., Desgranges, B., Vivien, D., Poisnel, G., & Chételat, G.
Affiliations
Inserm (FR)
ORCID
Venue
Alzheimer's Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2019-07-08
Volume
11
Issue
1
Pages
61-61
ISSN
1758-9193 (ISSN-L)
DOI
10.1186/s13195-019-0514-z
PMC
PMC6615169
OpenAlex
W2958121688
Cited by
51
References
21
Citations by year
2025: 7 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 6 · 2019: 2 · 2012: 1
FWCI
5.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Alzheimer s Research & Therapy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
Funders
  • Fondation Plan Alzheimer (Alzheimer Plan 2008–2012)
  • Programme Hospitalier de Recherche Clinique (PHRCN 2011-A01493-38 and PHRCN 2012 12-006-0347)
  • Agence Nationale de la Recherche (LONGVIE 2007)
  • Association France Alzheimer et maladies apparentées (AAP 2013)
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
subjective cognitive decline, memory clinic referral, subthreshold depression, subclinical anxiety, gray matter volume, glucose metabolism, Alzheimer's disease risk, older adults, praxis
MeSH terms
Mental Status and Dementia Tests, Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Cross-Sectional Studies, Depression, Female, Follow-Up Studies, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Biomarkers, Disease Progression, Neocortex, Positron-Emission Tomography, Diagnostic Self Evaluation, Cognitive Dysfunction, Prodromal Symptoms, Gray Matter

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