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Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric Disorders
Open accessAbstract
IMPORTANCE: Psychiatric disorders are heritable, polygenic traits, which often share risk alleles and for which nonrandom mating has been suggested. However, despite the potential etiological implications, the scale of nonrandom mating within and across major psychiatric conditions remains unclear. OBJECTIVE: To quantify the nature and extent of nonrandom mating within and across a broad range of psychiatric conditions at the population level. DESIGN, SETTING, AND PARTICIPANTS: Population-based cohort using Swedish population registers. Participants were all Swedish residents with a psychiatric diagnosis of interest (attention-deficit/hyperactivity disorder, autism spectrum disorder, schizophrenia, bipolar disorder, major depression, generalized anxiety disorder, agoraphobia, social phobia, obsessive-compulsive disorder, anorexia, or substance abuse), along with their mates. Individuals with select nonpsychiatric disorders (Crohn's disease, type 1 and type 2 diabetes mellitus, multiple sclerosis, or rheumatoid arthritis) were included for comparison. General population samples were also derived and matched 1:5 with each case proband. Inpatient and outpatient diagnostic data were derived from the Swedish National Patient Register (1973-2009), with analyses conducted between June 2014 and May 2015. MAIN OUTCOMES AND MEASURES: Correlation in the diagnostic status of mates both within and across disorders. Conditional logistic regression was used to quantify the odds of each diagnosis in the mates of cases relative to matched population controls. RESULTS: Across cohorts, data corresponded to 707 263 unique case individuals, with women constituting 45.7% of the full population. Positive correlations in diagnostic status were evident between mates. Within-disorder correlations were marginally higher (range, 0.11-0.48) than cross-disorder correlations (range, 0.01-0.42). Relative to matched populations, the odds of psychiatric case probands having an affected mate were significantly elevated. Differences in the magnitude of observed relationships were apparent by disorder (odds ratio range, 0.8-11.4). The number of comorbidities in a case proband was associated with the proportion of affected mates. These relationships were not apparent or weaker in magnitude among nonpsychiatric conditions (correlation range, -0.03 to 0.17). CONCLUSIONS AND RELEVANCE: Nonrandom mating is evident in psychiatric populations both within specific disorders and across the spectrum of psychiatric conditions. This phenomenon may hold important implications for how we understand the familial transmission of these disorders and for psychiatric genetic research.
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“Assortative mating has been reported among individuals with a diagnosis of OCD (51).”
From Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder (2020) · cites this paper as [51]
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“parental age might be confounded by parents with autism traits having children later in life, or choosing partners with high autism traits [252, 253].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [252]
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“Consequently, the evidence from a cross-disorder meta-analysis may not be due to pleiotropy (or not entirely) but may instead be an artefact of a residual genetic background from assortative mating between individuals with these diagnoses [73].”
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Citations
Cites
Introduction to Quantitative Genetics.
Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447
Introduction to Quantitative Genetics
J.-M., G., & Falconer, D. S. (1962) · Population · doi:10.2307/1525780 · Cited by 3,773
Introduction to quantitative genetics
Falconer, D. S. (1960) · Helmholtz Centre for Ocean Research Kiel (GEOMAR) · Cited by 3,170
(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125
Self-citationKendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.929 · Cited by 1,868
Baecklund, E., Iliadou, A. N., Askling, J., Ekbom, A., Backlin, C., Granath, F. N., Catrina, A. I., Rosenquist, R., Feltelius, N., Sundström, C., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21675 · Cited by 895
Genetics and intelligence differences: five special findings
Plomin, R., & Deary, I. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.105 · Cited by 702
Askling, J., Fored, C. M., Brandt, L., Baecklund, E., Bertilsson, L., Cöster, L., Geborek, P., Jacobsson, L., Lindblad, S., Lysholm, J., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21137 · Cited by 418
Assortative mating, or who marries whom?
Vandenberg, S. G. (1972) · Behavior Genetics · doi:10.1007/bf01065686 · Cited by 368
Genetics and Experience: The Interplay between Nature and Nurture
Plomin, R. J. (1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 359
Power, R. A., Kyaga, S., Uher, R., MacCabe, J. H., Långström, N., Landen, M., McGuffin, P., Lewis, C. M., Lichtenstein, P., & Svensson, A. C. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.268 · Cited by 336
Self-citationAgerbo, E., Sullivan, P. F., Vilhjálmsson, B. J., Pedersen, C. B., Mors, O., Børglum, A. D., Hougaard, D. M., Hollegaard, M. V., Meier, S., Mattheisen, M., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0346 · Cited by 319
Whitaker, K. L., Jarvis, M. J., Beeken, R. J., Boniface, D. R., & Wardle, J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28838 · Cited by 295
Assortative mating for antisocial behavior: Developmental and methodological implications
Krueger, R. F., Moffitt, T. E., Caspi, A., Bleske, A., & Silva, P. A. (1998) · Behavior Genetics · doi:10.1023/a:1021419013124 · Cited by 275
Family History of Schizophrenia and Bipolar Disorder as Risk Factors for Autism
Sullivan, P. F., Magnusson, C., Reichenberg, A., Boman, M., Dalman, C., Davidson, M., Fruchter, E., Hultman, C. M., Lundberg, M., Långström, N., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.730 · Cited by 266
Self-citationSevere Mental Disorders in Offspring With 2 Psychiatrically Ill Parents
Gottesman, I. I., Laursen, T. M., Bertelsen, A., & Mortensen, P. B. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.1 · Cited by 246
Appendectomy is followed by increased risk of Crohn's disease
Andersson, R. E., Olaison, G., Tysk, C., & Ekbom, A. (2003) · Gastroenterology · doi:10.1053/gast.2003.50021 · Cited by 245
Kendler, K. S., Gardner, C., & Lichtenstein, P. (2008) · Psychological Medicine · doi:10.1017/s003329170800384x · Cited by 225
Self-citationHigh nationwide prevalence of multiple sclerosis in Sweden
Ahlgren, C., Odén, A., & Lycke, J. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511403794 · Cited by 220
Population-Based, Multigenerational Family Clustering Study of Obsessive-compulsive Disorder
Mataix-Cols, D., Boman, M., Monzani, B., Rück, C., Serlachius, E., Långström, N., & Lichtenstein, P. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.3 · Cited by 207
Self-citationAssortative Mating for Psychiatric Disorders and Psychological Traits
Merikangas, K. R. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290100043007 · Cited by 205
Assortative mating for major psychiatric diagnoses in two population-based samples
MAES, H. H. M., NEALE, M. C., KENDLER, K. S., HEWITT, J. K., SILBERG, J. L., FOLEY, D. L., MEYER, J. M., RUTTER, M., SIMONOFF, E., PICKLES, A., et al. (1998) · Psychological Medicine · doi:10.1017/s0033291798007326 · Cited by 202
Larsson, H., Rydén, E., Boman, M., Långström, N., Lichtenstein, P., & Landén, M. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.120808 · Cited by 199
Self-citationRecurrence risks for schizophrenia in a Swedish National Cohort
LICHTENSTEIN, P., BJÖRK, C., HULTMAN, C. M., SCOLNICK, E., SKLAR, P., & SULLIVAN, P. F. (2006) · Psychological Medicine · doi:10.1017/s0033291706008385 · Cited by 197
Self-citationAssortative mating in the affective disorders: A systematic review and meta-analysis
Mathews, C. A. (2001) · Comprehensive Psychiatry · doi:10.1053/comp.2001.24575 · Cited by 150
Genetic Epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in Adults
Boomsma, D. I., Saviouk, V., Hottenga, J.-J., Distel, M. A., de Moor, M. H. M., Vink, J. M., Geels, L. M., van Beek, J. H. D. A., Bartels, M., de Geus, E. J. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010621 · Cited by 140
Cederlöf, M., Lichtenstein, P., Larsson, H., Boman, M., Rück, C., Landén, M., & Mataix‐Cols, D. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu169 · Cited by 124
Self-citationArpana Agrawal, A., Heath, A. C., Grant, J. D., Pergadia, M. L., Statham, D. J., Bucholz, K. K., Martin, N. G., & Madden, P. A. F. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9081-8 · Cited by 119
Rück, C., Larsson, K. J., Lind, K., Perez-Vigil, A., Isomura, K., Sariaslan, A., Lichtenstein, P., & Mataix-Cols, D. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007520 · Cited by 115
Self-citationGrant, J. D., Heath, A. C., Bucholz, K. K., Madden, P. A. F., Arpana Agrawal, A., Statham, D. J., & Martin, N. G. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00356.x · Cited by 100
Assortative mating among in-patients with primary affective disorder
Merikangas, K. R., & Spiker, D. G. (1982) · Psychological Medicine · doi:10.1017/s0033291700049059 · Cited by 92
The Impact of Environmental Experiences on Symptoms of Anxiety and Depression Across the Life Span
Kendler, K. S., Eaves, L. J., Loken, E. K., Pedersen, N. L., Middeldorp, C. M., Reynolds, C. A., Boomsma, D. I., Lichtenstein, P., Silberg, J. L., & Gardner, C. O. (2011) · Psychological Science · doi:10.1177/0956797611417255 · Cited by 80
Self-citationIsomura, K., Boman, M., Rück, C., Serlachius, E., Larsson, H., Lichtenstein, P., & Mataix-Cols, D. (2015) · Psychological Medicine · doi:10.1017/s0033291714002116 · Cited by 61
Self-citationGrootheest, D. S. V., van den Berg, S. M., Cath, D. C., Willemsen, G. A. H. M., & Boomsma, D. I. (2008) · Psychological Medicine · doi:10.1017/s0033291708003024 · Cited by 38
Heun, R., & Maier, W. (1993) · Comprehensive Psychiatry · doi:10.1016/0010-440x(93)90059-d · Cited by 27
Mattheisen, M., Vilhjálmsson, B. J., Meier, S. M., Ripke, S., Pedersen, C. B., Mors, O. N., Hollegaard, M. V., Børglum, A. D., HOUGAARD, D. M., Mortensen, P. B., et al. (2021) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/26py-0j59 · Cited by 25
Identifying bipolar disorder susceptibility loci in a densely affected pedigree
Collins, A. L., Kim, Y., Szatkiewicz, J., Bloom, R. J., Hilliard, C. E., Quackenbush, C. R., Meier, S., Rivas, F., Mayoral, F., Cichon, S., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.176 · Cited by 24
Sibling risk of anxiety disorders based on hospitalizations in Sweden
Li, X., Sundquist, J., & Sundquist, K. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2011.02199.x · Cited by 13
Arpana Agrawal, A., Heath, A. C., Grant, J. D., Pergadia, M. L., Bucholz, K. K., Madden, P. A. F., Statham, D. J., & Martin, N. G. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9112-5 · Cited by 8
(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone
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The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017) · Molecular Autism · doi:10.1186/s13229-017-0137-9 · Cited by 587
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Metadata
- Authors
- Nordsletten, A. E., Larsson, H., Crowley, J. J., Almqvist, C., Lichtenstein, P., & Mataix-Cols, D.
- Affiliations
- Karolinska Institutet (SE)
- University of North Carolina at Chapel Hill (US)
- Karolinska University Hospital (SE)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
- Corresponding author
- Nordsletten, Ashley E.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2016-04-01
- Volume
- 73
- Issue
- 4
- Pages
- 354
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC5082975
- OpenAlex
- W2282446826
- Cited by
- 210
- References
- 42
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 25 · 2023: 16 · 2022: 28 · 2021: 17 · 2020: 18 · 2019: 23 · 2018: 28 · 2017: 21 · 2016: 12
- FWCI
- 22.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- King's College London
- Vetenskapsrådet (340–2013-5867)
- National Institute of Mental Health (R01MH105500)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- disorder, non-random mating, mate choice, genetic correlation, family transmission, comorbidities, schizophrenia, bipolar disorder, major depressive disorder, attention deficit hyperactivity disorder, autism spectrum disorder, obsessive-compulsive disorder, anorexia nervosa, substance abuse, agoraphobia, social anxiety disorder, generalized anxiety disorder, polygenic traits, heritability
- MeSH terms
- Adult, Aged, Mental Disorders, Female, Humans, Male, Middle Aged, Registries, Sampling Studies, Sexual Behavior, Sweden, Cohort Studies, Confounding Factors, Epidemiologic, Logistic Models, Odds Ratio, Spouses, Genetic Research
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