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Functional magnetic resonance imaging-guided personalization of transcranial magnetic stimulation treatment for depression
Open accessAbstract
This study assesses whether treatment response for depression could be improved via a single one-site-fits-all dorsolateral prefrontal cortex target, representing the group average optimal site of subgenual cingulate cortex functional connectivity, or whether target site personalization is necessary.
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“Two recent papers found that clinical efficacy of rTMS for depression was greater when the scalp-targeted stimulation site was incidentally closer to the optimal rsfMRI-derived site (38, 39).”
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Metadata
- Authors
- Cash, R. F. H., Cocchi, L., Lv, J., Fitzgerald, P. B., & Zalesky, A.
- Affiliations
- The University of Melbourne (AU)
- QIMR Berghofer Medical Research Institute (AU)
- The University of Sydney (AU)
- Epworth Hospital (AU)
- Corresponding author
- Cash, Robin F. H.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2021-03-01
- Volume
- 78
- Issue
- 3
- Pages
- 337
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC7689561
- OpenAlex
- W3109502500
- Cited by
- 291
- References
- 5
- Citations by year
- 2026: 60 · 2025: 63 · 2024: 63 · 2023: 46 · 2022: 33 · 2021: 25
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- transcranial magnetic stimulation, depression, treatment response, dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, functional connectivity, personalized treatment
- MeSH terms
- Dorsolateral Prefrontal Cortex, Adult, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Outcome and Process Assessment, Health Care, Transcranial Magnetic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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