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Functional magnetic resonance imaging-guided personalization of transcranial magnetic stimulation treatment for depression
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This study assesses whether treatment response for depression could be improved via a single one-site-fits-all dorsolateral prefrontal cortex target, representing the group average optimal site of subgenual cingulate cortex functional connectivity, or whether target site personalization is necessary.
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“Two recent papers found that clinical efficacy of rTMS for depression was greater when the scalp-targeted stimulation site was incidentally closer to the optimal rsfMRI-derived site (38, 39).”
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Metadata
- Authors
- Cash, R. F. H., Cocchi, L., Lv, J., Fitzgerald, P. B., & Zalesky, A.
- Affiliations
- The University of Melbourne (AU)
- QIMR Berghofer Medical Research Institute (AU)
- The University of Sydney (AU)
- Epworth Hospital (AU)
- Corresponding author
- Cash, Robin F. H.
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2021-03-01
- Volume
- 78
- Issue
- 3
- Pages
- 337
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC7689561
- OpenAlex
- W3109502500
- Cited by
- 291
- References
- 5
- Citations by year
- 2026: 60 · 2025: 63 · 2024: 63 · 2023: 46 · 2022: 33 · 2021: 25
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- transcranial magnetic stimulation, depression, treatment response, dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, functional connectivity, personalized treatment
- MeSH terms
- Dorsolateral Prefrontal Cortex, Adult, Brain Mapping, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Outcome and Process Assessment, Health Care, Transcranial Magnetic Stimulation
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