Preaddiction—A Missing Concept for Treating Substance Use Disorders

McLellan, A. Thomas; Koob, George F.; Volkow, Nora D.

doi:10.1001/jamapsychiatry.2022.1652

Cited by 112Substance Abuse Treatment and OutcomesOpioid Use Disorder TreatmentGambling Behavior and Treatments

Preaddiction—A Missing Concept for Treating Substance Use Disorders

McLellan, A. Thomas, Koob, George F., Volkow, Nora D.·2022·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2022.1652

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In the early stage of a SUD (mild SUD), the urge for drug consumption can be regulated, and this could be considered a 'pre-addiction' stage that could be targeted for early prevention interventions.
“In the early stage of a SUD (mild SUD), the urge for drug consumption can be regu lated, and we recently proposed that this could be considered as a 'pre- addiction' stage that could be targeted for early prevention interventions 15 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [15]
The authors recently proposed the new term 'pre-addiction' to identify the early stages of a SUD (mild SUD, as per DSM-5) as a focus of attention in screening for problematic drug use.
“Consequently, we recently proposed the new term 'pre- ad diction' to identify the early stages of a SUD (mild SUD, as per DSM 5) as a focus of attention in screening for problematic drug use 15 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [15]
The ongoing discourse surrounding the integration of the concept of 'preaddiction' offers a potential paradigm shift, suggesting a potential alternative to the mild or moderate substance use disorder criteria in DSM-5-TR.
“The ongoing discourse surrounding the integration of the concept of ‘preaddiction’ [128] offers a potential paradigm shift, suggesting a potential alternative to the mild or moderate substance use disorder criteria in DSM-5-TR.”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [128]

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Authors: McLellan, A. T., Koob, G. F., & Volkow, N. D.
Affiliations: University of Pennsylvania (US)
National Institutes of Health (US)
ORCID: Koob, George F.
Volkow, Nora D.
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2022-08-01
Volume: 79
Issue: 8
Pages: 749
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2022.1652
OpenAlex: W4284664202
Cited by: 112
References: 7
Citations by year: 2026: 8 · 2025: 17 · 2024: 37 · 2023: 34 · 2022: 16
FWCI: 18.85
Type: journal article
Language: en
Open access: closed
Locations: JAMA Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: substance use disorders, addiction treatment, relapse prevention, addiction prevention
MeSH terms: Humans, Substance-Related Disorders

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Preaddiction—A Missing Concept for Treating Substance Use Disorders

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