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Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites
Abstract
Hypercortisolemia is often observed in patients suffering from major depression. As the serotonergic (5-hydroxytryptamine; 5-HT) system plays a major role in the etiology of depression, a loss of endocrine and neurotransmitter system interactions, including corticosterone regulation of 5-HT transporter (5-HTT) and 5-HT receptor expression, may underlie age-related deficits in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and correlate with an increased incidence of depression with advancing age. In this study, female Fischer 344 rats, ages 3, 13, and 18 months, were bilaterally adrenalectomized and supplemented for 3 weeks with corticosterone (0, 200, or 600 mg; LC, MC, or HC, respectively) containing 21 day sustained-release pellets implanted subcutaneously. Quantitative autoradiography of hippocampal and cortical regions using [3H]citalopram revealed a significant decrease in hippocampal 5-HTT binding in the 3-month HC treatment group compared to age-matched MC and LC groups; this loss was not present in the 13- or 18-month groups. Similarly, quantitative autoradiography using the radiolabeled 5-HT(1A) receptor agonist 8-hydroxy-2-(di-N-propylamino) tetralin demonstrated a significant decline in receptor density in 3- and 13-month MC and HC groups as compared to age-matched LC groups in the hippocampus. These hormone treatments (MC or HC), however, failed to alter hippocampal 5-HT(1A) binding site density in the 18-month groups as compared to the age-matched LC group. The 5-HT(2A) receptor was also evaluated using [3H]ketanserin and showed no age- or corticosterone-related changes in the cortex. Overall, an age-associated deficit in the regulation of the hippocampal serotonergic system by varied corticosterone treatment was revealed in the present study, which may underlie the increased incidence of depression and hypercortisolemia found with advancing age.
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In the citing paper
“the PVT is one of the most stress-responsive areas in the brain, based on the induction of a marker of cellar activity, c-Fos, with various stressors”
From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Bubser and Deutch, 1999
In the citing paper
“For example, acute footshock in rats activates paraventricular neurons that project to the medial prefrontal cortex, accumbens nucleus, and the amygdala (Bubser and Deutch, 1999)”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Bubser and Deutch, 1999
In the citing paper
“Likewise, early maternal deprivation models in the very early juvenile period (from post-natal day 5) have been associated with hypodopaminergic behaviours in later life including reduced or attenuated responses to acute stress, conditioned locomotion, locomotor activity, and dopamine agonist-induced locomotion with amphetamine, alongside potentiated dopamine antagonist-induced decreases in antici”
From The effects of psychosocial stress on dopaminergic function and the acute stress response (2019) · cites this paper as Hall et al., 1999
In the citing paper
“For example, maternal deprivation and isolation of neonatal rats was associated with increased dopamine release (Hall et al., 1999; Kosten et al., 2003)”
From The effects of psychosocial stress on dopaminergic function and the acute stress response (2019) · cites this paper as Hall et al., 1999
In the citing paper
“other studies demonstrate enhanced mesolimbic dopamine function, as evidenced by increased nucleus accumbens dopamine release in response to stress (Brake et al., 2004) or amphetamine (Hall et al., 1999), as well as increased locomotion in response to cocaine (Brake et al., 2004).”
From The effects of early life stress on reward processing (2018) · cites this paper as Hall et al., 1999
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Metadata
- Authors
- Bubser, M., & Deutch, A. Y.
- Venue
- Synapse
- Published
- 1999
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- Bubser, M., & Deutch, A. Y. (1999). Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Synapse. https://doi.org/10.1002/(sici)1098-2396(199904)32%3A1
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