The Epithelium in Inflammatory Bowel Disease: Potential Role of Endocytosis of Junctional Proteins in Barrier Disruption

Multifunctional strands in tight junctions

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Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

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Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins

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REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS

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Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

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Inflammatory bowel disease is associated with changes of enterocytic junctions

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Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ

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Modulation of tight junction structure and function by cytokines

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Non-invasive investigation of inflammatory bowel disease

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Tumor Necrosis Factor-α Increases Sodium and Chloride Conductance Across the Tight Junction of CACO-2 BBE, a Human Intestinal Epithelial Cell Line

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Tumour Necrosis factor-α induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers

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Alterations in classical cadherins associated with progression in ulcerative and Crohn's colitis.

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Intracellular Redirection of Plasma Membrane Trafficking after Loss of Epithelial Cell Polarity

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CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT

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Mechanism of cytokine modulation of epithelial tight junction barrier

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Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

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IL-1β and the Intestinal Epithelial Tight Junction Barrier

Kaminsky, L. W., Al–Sadi, R., & Ma, T. Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767456 · Cited by 441 · see citing works

Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier

Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works

Interferon‐γ induces internalization of epithelial tight junction proteins via a macropinocytosis‐like process

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Disruption of the epithelial barrier during intestinal inflammation: Quest for new molecules and mechanisms

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Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis

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Claudins in intestines

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Regulation and roles for claudin‐family tight junction proteins

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Inflammatory Bowel Disease and the Apical Junctional Complex

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Epidermal tight junctions in health and disease

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Protective Effects of Bifidobacterium on Intestinal Barrier Function in LPS-Induced Enterocyte Barrier Injury of Caco-2 Monolayers and in a Rat NEC Model

Ling, X., Peng, L., Du, W., & Wei, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161635 · Cited by 202 · see citing works

Intestinal Epithelial Barrier Dysfunction in Disease and Possible Therapeutical Interventions

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Vitamin D, vitamin D receptor and tissue barriers

Zhang, Y., Wu, S., & Sun, J. (2013) · Tissue Barriers · doi:10.4161/tisb.23118 · Cited by 164 · see citing works

Genetics of ulcerative colitis

Thompson, A., & Lees, C. W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21375 · Cited by 166 · see citing works

Dynamic Regulation of Barrier Integrity of the Corneal Endothelium

Srinivas, S. P. (2010) · Optometry and Vision Science · doi:10.1097/opx.0b013e3181d39464 · Cited by 160 · see citing works

A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis

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Polymorphisms in E-cadherin ( CDH1 ) result in a mis-localised cytoplasmic protein that is associated with Crohn’s disease

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A short guide to the tight junction

Citi, S., Fromm, M., Furuse, M., González‐Mariscal, L., Nusrat, A., Tsukita, S., & Turner, J. R. (2024) · Journal of Cell Science · doi:10.1242/jcs.261776 · Cited by 151 · see citing works

Deoxynivalenol: a trigger for intestinal integrity breakdown

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Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro : A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines

Amasheh, M., Grotjohann, I., Amasheh, S., Fromm, A., Söderholm, J. D., Zeitz, M., Fromm, M., & Schulzke, J. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903131973 · Cited by 131 · see citing works

Endocytosis and Recycling of Tight Junction Proteins in Inflammation

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Defects in the adherens junction complex (E-cadherin/ β-catenin) in inflammatory bowel disease

Mehta, S. J., Nijhuis, A. M., Kumagai, T., Lindsay, J. O., & Silver, A. R. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1994-6 · Cited by 105 · see citing works

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Shil, A., Olusanya, O., Ghufoor, Z., Forson, B., Marks, J., & Chichger, H. (2020) · Nutrients · doi:10.3390/nu12061862 · Cited by 103 · see citing works

Vitamin D Receptor Influences Intestinal Barriers in Health and Disease

Sun, J., & Zhang, Y. (2022) · Cells · doi:10.3390/cells11071129 · Cited by 100 · see citing works

Actin motors that drive formation and disassembly of epithelial apical junctions

Andrei, I. I. (2008) · Frontiers in bioscience · doi:10.2741/3180 · Cited by 96 · see citing works

Altered claudin expression is a feature of chronic plaque psoriasis

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Salmonella Infection Upregulates the Leaky Protein Claudin-2 in Intestinal Epithelial Cells

Zhang, Y.-G., Wu, S., Xia, Y., & Sun, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058606 · Cited by 82 · see citing works

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 5: Intercellular junctions and contacts between germs cells and Sertoli cells and their regulatory interactions, testicular cholesterol, and genes/proteins associated with more than one germ cell generation

Hermo, L., Pelletier, R. ‐., Cyr, D. G., & Smith, C. E. (2009) · Microscopy Research and Technique · doi:10.1002/jemt.20786 · Cited by 76 · see citing works

Claudins—Key Pieces in the Tight Junction Puzzle

Koval, M. H. (2006) · Cell Communication & Adhesion · doi:10.1080/15419060600726209 · Cited by 72 · see citing works

Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflammatory Bowel Disease

Gong, Y., Li, H., & Li, Y. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2015.0030 · Cited by 67 · see citing works

CD73 Is Critical for the Resolution of Murine Colonic Inflammation

Bynoe, M. S., Waickman, A. T., Mahamed, D., Mueller, C., Mills, J. H., & Czopik, A. K. (2012) · BioMed Research International · doi:10.1155/2012/260983 · Cited by 65 · see citing works

Dynamics of enterocyte tight junctions: effect of experimental colitis and two different anti-TNF strategies

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Tight Junctions and the Intestinal Barrier

Ma, T. Y., Anderson, J. M., & Turner, J. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00038-5 · Cited by 67 · see citing works

Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation

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Insights of Endocytosis Signaling in Health and Disease

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Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules

Tang, V. (2006) · Biology Direct · doi:10.1186/1745-6150-1-37 · Cited by 66 · see citing works

Disruption of CDH2/N-Cadherin–Based Adherens Junctions Leads to Apoptosis of Ependymal Cells and Denudation of Brain Ventricular Walls

Oliver, C., González, C., Alvial, G., Flores, C. A., Rodríguez, E. M., & Bátiz, L. F. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182a2d5fe · Cited by 59 · see citing works

Endocytosis of Intestinal Tight Junction Proteins: In Time and Space

Nighot, P., & Ma, T. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa141 · Cited by 58 · see citing works

Developmental Expression of Claudins in the Mammary Gland

Baumgartner, H. K., Rudolph, M. C., Ramanathan, P., Burns, V., Webb, P. G., Bitler, B. G., Stein, T., Kobayashi, K., & Neville, M. C. (2017) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-017-9379-6 · Cited by 58 · see citing works

The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities

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Review article: nitric oxide from dysbiotic bacterial respiration of nitrate in the pathogenesis and as a target for therapy of ulcerative colitis

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Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-Prone Mice without Apparent Glucocorticoid Side Effects

Jia, Z., Wang, X., Wei, X., Zhao, G., Foster, K. W., Qiu, F., Gao, Y., Fang, Y., Yu, F., Thiele, G. M., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b01249 · Cited by 54 · see citing works

Gonadotropins Regulate Rat Testicular Tight Junctions in Vivo

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Structural and Functional Alteration of Corneal Epithelial Barrier Under Inflammatory Conditions

Contreras‐Ruiz, L., Schulze, U., García-Posadas, L., Arranz-Valsero, I., López‐García, A., Paulsen, F. P., & Diebold, Y. (2012) · Current Eye Research · doi:10.3109/02713683.2012.700756 · Cited by 48 · see citing works

Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage

Zhang, Z., Li, Y., Shen, P. F., Li, S., Lu, X., Liu, J., Cao, Y., Liu, B., Fu, Y., & Zhang, N. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.033 · Cited by 46 · see citing works

Tight Junctions and the Intestinal Barrier

Ma, T. Y., Nighot, P. K., & Al–Sadi, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00025-6 · Cited by 41 · see citing works

Carbon Monoxide-Releasing Molecule-2 Reduces Intestinal Epithelial Tight-Junction Damage and Mortality in Septic Rats

Zhang, S., Zheng, S., Wang, X., Shi, Q., Wang, X., Yuan, S.-T., Wang, G., & Ji, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145988 · Cited by 39 · see citing works

The Claudin Megatrachea Protein Complex

Jaspers, M. H. J., Nolde, K., Behr, M., Joo, S.-H., Plessmann, U., Nikolov, M., Urlaub, H., & Schuh, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399410 · Cited by 36 · see citing works

Emerging clinical significance of claudin-7 in colorectal cancer: a review

Wang, K., Xu, C., Li, W., & Ding, L. (2018) · Cancer Management and Research · doi:10.2147/cmar.s175383 · Cited by 34 · see citing works

Corrigendum: Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier

Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790387 · Cited by 34 · see citing works

Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway

Zhang, Y., Wu, S., Ma, J., Xia, Y., Ai, X., & Sun, J. (2014) · Tissue Barriers · doi:10.4161/21688362.2014.972849 · Cited by 31 · see citing works

Synergistic Protective Effect of Konjac Mannan Oligosaccharides and Bacillus subtilis on Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell Model and Mice Model of Lipopolysaccharide Stimulation

Chen, L., Zhang, S., Wu, S., Ren, Z., Liu, G., & Wu, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.696148 · Cited by 33 · see citing works

BLOOD-BRAIN BARRIER CHANGES DURING COMPENSATED AND DECOMPENSATED HEMORRHAGIC SHOCK

Krizbai, I. A., Lenzsér, G., Szatmari, E. M., Farkas, A. E., Wilhelm, I., Fekete, Z., Erdös, B., Bauer, H., Bauer, H., Sándor, P., et al. (2005) · Shock · doi:10.1097/01.shk.0000183389.98519.d3 · Cited by 33 · see citing works

Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea

Ok, M., Yıldız, R., Hatıpoğlu, F., Başpınar, N., İder, M., Üney, K., Ertürk, A., Durgut, M. K., & Terzi̇, F. (2020) · American Journal of Veterinary Research · doi:10.2460/ajvr.81.2.139 · Cited by 31 · see citing works

Campylobacter and IFNγ interact to cause a rapid loss of epithelial barrier integrity

Rees, L., Cogan, T. A., Dodson, A., Birchall, M., Bailey, M., & Humphrey, T. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20325 · Cited by 31 · see citing works

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

Bandyopadhyay, C., Schecterson, L. C., & Gumbiner, B. M. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1940741 · Cited by 29 · see citing works

Protective Effects of Live Combined B. subtilis and E. faecium in Polymicrobial Sepsis Through Modulating Activation and Transformation of Macrophages and Mast Cells

Guo, L., Meng, M., Wei, Y., Lin, F., Jiang, Y., Cui, X., Wang, G., Wang, C., & Guo, X. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01506 · Cited by 28 · see citing works

Claudin‐derived peptides are internalized via specific endocytosis pathways

Zwanziger, D., Staat, C., Andjelkovic, A. V., & Blasig, I. E. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06567.x · Cited by 26 · see citing works

Regulation of Tight Junction Assembly and Epithelial Polarity by a Resident Protein of Apical Endosomes

McCarter, S. D., Johnson, D. L., Kitt, K. N., Donohue, C., Adams, A., & Wilson, J. M. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01052.x · Cited by 24 · see citing works

Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis

Buzza, M. S., Johnson, T. A., Conway, G. D., Martin, E. W., Mukhopadhyay, S., Shea‐Donohue, T., & Antalis, T. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.771469 · Cited by 24 · see citing works

Tumor Necrosis Factor‐α Increases Claudin‐1, 4, and 7 Expression in Tubular Cells: Role in Permeability Changes

Amoozadeh, Y., Dan, Q., Anwer, S., Huang, H. H., Barbieri, V., Waheed, F., Maishan, M., & Szászi, K. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25736 · Cited by 23 · see citing works

Decay-Accelerating Factor Binding Determines the Entry Route of Echovirus 11 in Polarized Epithelial Cells

Sobo, K., Rubbia‐Brandt, L., Brown, T. D. K., Stuart, A. D., & McKee, T. (2011) · Journal of Virology · doi:10.1128/jvi.00016-11 · Cited by 20 · see citing works

Effects of Qing Hua Chang Yin on lipopolysaccharide‑induced intestinal epithelial tight junction injury in Caco‑2 cells

Fang, W., Zhao, P., Shen, A., Liu, L., Chen, H., Chen, Y., Peng, J., Sferra, T. J., Sankararaman, S., Luo, Y., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11844 · Cited by 19 · see citing works

Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis

Gülersoy, E., Ok, M., Yıldız, R., Koral, E., İder, M., Sevinç, M., & Zhunushova, A. (2020) · Polish Journal of Veterinary Sciences · doi:10.24425/pjvs.2020.133635 · Cited by 19 · see citing works

Association of postural orthostatic tachycardia syndrome, hypermobility spectrum disorders, and mast cell activation syndrome in young patients; prevalence, overlap and response to therapy depends on the definition

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From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD

Schulze, H., Häsler, R., Mah, N., Lu, T. T., Nikolaus, S., Costello, C. M., & Schreiber, S. (2008) · Genes and Immunity · doi:10.1038/gene.2008.11 · Cited by 18 · see citing works

SIRT1 Stabilizes β-TrCP1 to Inhibit Snail1 Expression in Maintaining Intestinal Epithelial Integrity to Alleviate Colitis

Wang, L., Li, J., Jiang, M., Luo, Y., Xu, X., Li, J., Pan, Y., Zhang, H., Xiao, Z. J., & Wang, Y. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.05.002 · Cited by 16 · see citing works

Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway

Tao, H., Bao, Z., Fu, Z., & Jin, Y. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab125 · Cited by 14 · see citing works

Hymenolepis diminuta: The effects of infection on transepithelial ion transport and tight junctions in rat intestines

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Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice

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