The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Overview of Admixture Mapping
Open accessAbstract
Admixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to African Americans who trace ancestry to Europeans and West Africans. Recent developments in admixture mapping include improvements in methods to take advantage of higher densities of genetic variants, as well as extensions to admixed populations with three or more ancestral populations, such as Latino Americans. In this unit, the author outlines the key concepts of admixture mapping. The author describes several approaches for inferring local ancestry and provides strategies for performing admixture mapping depending on the study design. Finally, the author compares and contrasts linkage analysis, association analysis, and admixture mapping, with an emphasis on integrating admixture mapping and association testing. Curr. Protoc. Hum. Genet. 76:1.23.1‐1.23.8. © 2013 by John Wiley & Sons, Inc.
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“European Americans are often used as proxies for Europeans in genetic studies.26”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [26]
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Cites
A STANDARDIZED GENETIC DIFFERENTIATION MEASURE
Hedrick, P. W. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb01814.x · Cited by 1,839
RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference
Maples, B. K., Gravel, S., Kenny, E. E., & Bustamante, C. D. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.06.020 · Cited by 900
Informativeness of Genetic Markers for Inference of Ancestry*
Rosenberg, N. A., Li, L. M., Ward, R. H., & Pritchard, J. K. (2003) · The American Journal of Human Genetics · doi:10.1086/380416 · Cited by 710
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
Price, A. L., Tandon, A., Patterson, N., Barnes, K. C., Rafaels, N., Ruczinski, I., Beaty, T. H., Mathias, R., Reich, D., & Myers, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000519 · Cited by 539
Methods for High-Density Admixture Mapping of Disease Genes
Patterson, N. J., Hattangadi, N., Lane, B., Lohmueller, K. E., Hafler, D. A., Oksenberg, J. R., Hauser, S. L., Smith, M. W., O’Brien, S. J., Altshuler, D., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/420871 · Cited by 475
A High-Density Admixture Map for Disease Gene Discovery in African Americans
Smith, M. W., Patterson, N., Lautenberger, J. A., Truelove, A. L., McDonald, G. J., Waliszewska, A., Kessing, B. D., Malasky, M. J., Scafe, C., Le, E., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/420856 · Cited by 459
A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
Adeyemo, A., Gerry, N. P., Chen, G., Herbert, A. G., Doumatey, A. P., Huang, H., Zhou, J., Lashley, K., Chen, Y., Christman, M. F., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000564 · Cited by 389
Estimating Local Ancestry in Admixed Populations
Sankararaman, S., Sridhar, S., Kimmel, G., & Halperin, E. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.022 · Cited by 354
Genomic Ancestry of North Africans Supports Back-to-Africa Migrations
Henn, B. M., Botigué, L. R., Gravel, S., Wang, W., Brisbin, A., Byrnes, J. K., Fadhlaoui-Zid, K., Zalloua, P. A., Moreno-Estrada, A., Bertranpetit, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002397 · Cited by 331
The landscape of recombination in African Americans
Hinch, A. G., Tandon, A., Patterson, N. J., Song, Y., Rohland, N., Palmer, C. D., Chen, G. K., Wang, K., Buxbaum, S. G., Akylbekova, E. L., et al. (2011) · Nature · doi:10.1038/nature10336 · Cited by 316
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Characterizing the genetic architecture of chronic kidney disease
Tran, K. N. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.244665
Defining the genetic profile of prostate cancer
Ajayi, A. F., Hamed, M. A., Onaolapo, M. C., Fiyinfoluwa, O. H., Oyeniran, O., & Oluwole, D. T. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.11.018
Defining Genetic Ancestry: Implications for Nurses
Jimenez, A., Lindquist, K. J., Longoria, K. D., STROEBEL, B. M., Aouizerat, B. E., & Flowers, E. (2025) · Biological Research For Nursing · doi:10.1177/10998004251374146
“…for quanti-fi cation of percentages of ancestral genetic characteristics and population substructure have been developed, tested, and described in prior review papers focused primarily on computational frameworks and statistical implementation (Enoch et al., 2006; Liu et al., 2013; Shriner, 2013).”
Admixture Mapping of Lipid Traits in Hispanic Americans
Ding, K., Johar, A., Zaidi, A. A., Crane, P. K., Edwards, D. R. V., Jarvik, G. P., Karlson, E. W., Rosenthal, E. A., Stanaway, I. B., Weng, C., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.036650
“16,17 The core principle underlying admixture mapping is that differences in local ancestry (ie, the array of ancestral segments along the genome 18 ) may explain differences in trait prevalence/ distribution.”
Peripheral Blood Nascent RNA Sequencing Captures Ancestry-Linked Differential Gene ExpressionPreprint
Kimm, A. K., Uh, E. G., & Kwak, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.699738
Explaining the unexplained admixture mapping signals via rare variants: the HCHS/SOL
Chen, X., Argos, M., Yu, B., Boerwinkle, E., QI, Q., Kaplan, R. C., Franceschini, N., & Sofer, T. (2026) · Human Molecular Genetics · doi:10.1093/hmg/ddag098
The role of admixture in the adaptation of human populations to changing environments
Cuadros-Espinoza, S. (2022) · theses.fr (ABES) · doi:10.70675/8ddb3c96z6256z4113z972fz6589a03fb4fc
Harris, R. D., Shetty, P. B., Taylor, O. A., Atkinson, E. G., Richard, M. A., Gramatges, M. M., Zobeck, M. C., Pruitt, S. L., Hughes, A. E., Bernhardt, M. B., et al. (2026) · Pediatric Blood & Cancer · doi:10.1002/1545-5017.70554
Genomic Insights Into Heterosis: Dominance or Additive × Additive Interaction?
Rogberg‐Muñoz, A., Steibel, J. P., Martini, J. W. R., Munilla, S., Forneris, N. S., Garcia-Baccino, C., Ernst, C. W., Bates, R. O., Giovambattista, G., & Cantet, R. J. C. (2026) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.70075
Metadata
- Authors
- Shriner, D.
- Affiliations
- National Human Genome Research Institute (US)
- Corresponding author
- Shriner, Daniel
- ORCID
- Shriner, Daniel
- Venue
- Current Protocols in Human Genetics
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 76
- Issue
- 1
- Pages
- 1.23.1-1.23.8
- ISSN
- 1934-8258 (ISSN-L)
- 1934-8266
- PMC
- PMC3556814
- OpenAlex
- W1588484659
- Cited by
- 111
- References
- 24
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 16 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 11 · 2016: 2 · 2015: 3 · 2014: 7
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Protocols in Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 HL999999, Z99 MH999999, Z99 HG999999, 1ziahg200362-15, Z01HG200362))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- admixture mapping, local ancestry inference, gene mapping, African Americans, Hispanic Americans, linkage analysis, association analysis, admixed populations, genetic variants
- MeSH terms
- Black or African American, Chromosome Mapping, Hispanic or Latino, Humans, Genetic Linkage, Phenotype, Genome, Human, Quantitative Trait Loci, Black People, White People, Genetic Association Studies
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