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DNA Mutation Detection Using Denaturing High‐Performance Liquid Chromatography (DHPLC)
Abstract
DHPLC is an efficient method for candidate gene scanning with a high level of automation. Single‐base substitutions and insertions or deletions of up to 1.5 kb in PCR amplified DNA fragments can be detected. The method exploits the differential retention of homoduplex and heteroduplex DNA species under conditions of partial thermal denaturation. DHPLC provides a useful platform for high‐throughput mutation detection and SNP discovery.
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Cited by
Y chromosome sequence variation and the history of human populations
Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., et al. (2000) · Nature Genetics · doi:10.1038/81685 · Cited by 715
Self-citationUnderhill, P. A., Jin, L., Lin, A. A., Mehdi, S. Q., Jenkins, T., Vollrath, D., Davis, R. W., Cavalli-Sforza, L. L., & Oefner, P. J. (1997) · Genome Research · doi:10.1101/gr.7.10.996 · Cited by 657
Self-citationDisease-targeted sequencing: a cornerstone in the clinic
Rehm, H. L. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3463 · Cited by 377
Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P., & O’Donovan, M. C. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.8.1133 · Cited by 274
Self-citationExcavating Y-chromosome haplotype strata in Anatolia.
Cinnioglu, C., King, R., Kivisild, T., Kalfoglu, E., Atasoy, S., Cavalleri, G. L., Lillie, A. S., Roseman, C. C., Lin, A. A., Prince, K., et al. (2004) · Human Genetics · doi:10.1007/s00439-003-1031-4 · Cited by 273
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Metadata
- Authors
- Yu, B., Sawyer, N. A., Chiu, C., Oefner, P. J., & Underhill, P. A.
- Venue
- Current Protocols in Human Genetics
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 48
- Issue
- 1
- Pages
- Unit7.10-Unit7.10
- ISSN
- 1934-8258 (ISSN-L)
- 1934-8266
- OpenAlex
- W1553785355
- Cited by
- 184
- References
- 0
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, B., Sawyer, N. A., Chiu, C., Oefner, P. J., & Underhill, P. A. (2006). DNA Mutation Detection Using Denaturing High‐Performance Liquid Chromatography (DHPLC). Current Protocols in Human Genetics. https://doi.org/10.1002/0471142905.hg0710s48
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