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Cited by 715

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Y chromosome sequence variation and the history of human populations

Underhill, Peter A., Shen, Peidong, Lin, Alice A., Jin, Li, Passarino, Giuseppe, Yang, Wei H., Kauffman, Erin, Bonné-Tamir, Batsheva, Bertranpetit, Jaume, Francalacci, Paolo, Ibrahim, Muntaser, Jenkins, Trefor, Kidd, Judith R., Mehdi, S. Qasim, Seielstad, Mark T., Wells, R. Spencer, Piazza, Alberto, Davis, Ronald W., Feldman, Marcus W., Cavalli-Sforza, L. Luca, Oefner, Peter. J.·2000·Nature Genetics
DOI 10.1038/81685
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Abstract

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

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Research works printed but not linked: 26

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Metadata

Authors
Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., Ibrahim, M., Jenkins, T., Kidd, J. R., Mehdi, S. Q., Seielstad, M. T., Wells, R. S., Piazza, A., Davis, R. W., Feldman, M. W., Cavalli-Sforza, L. L., & Oefner, P. J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2000-11
Volume
26
Issue
3
Pages
358-361
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/81685
Cited by
715
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Y chromosome sequence variation and the history of human populations. https://app.cochat.ai/papers/10.1038/81685
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Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., Ibrahim, M., Jenkins, T., Kidd, J. R., Mehdi, S. Q., Seielstad, M. T., Wells, R. S., Piazza, A., Davis, R. W., Feldman, M. W., . . . Oefner, P. J. (2000). Y chromosome sequence variation and the history of human populations. Nature Genetics. https://doi.org/10.1038/81685