Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
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TN-R−/− mice are TN-R knockout.
“TN-R knockout mice (TN-R−/−)”
From Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress (2014) · cites this paper as [34]
Tenascin-R (TnR) is a pivotal constituent of PNNs and its elimination leads to a change of PNN distribution, composition and function.
“TnR is a pivotal constituent of PNNs and its elimination leads to a change of PNN distribution, composition and function46.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [46]
A developmental upregulation of aggrecan and brevican, which peak in adulthood, was reported in rat brain.
“A developmental upregulation of aggrecan and brevican, which peak in adulthood, was reported in rat brain (Milev et al., 1998; Brückner et al., 2000; Popp et al., 2003).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Brückner et al., 2000
By week 4, tenascin expression is reduced to adult levels.
“By week 4, tenascin expression is reduced to adult levels (Brückner et al., 2000).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Brückner et al., 2000
In the mouse cortex, tenascin immunolabeling is first detected around E16 and tenascin levels increase after birth until the third postnatal week.
“In the mouse cortex, tenascin immunolabeling is first detected around E16 (Sheppard et al., 1991) and tenascin levels increase after birth until the third postnatal week (Brückner et al., 2000).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Brückner et al., 2000
Tenascin-R knockout mice show abnormal perineuronal net staining, with irregular distribution of WFA around soma and dendrites.
“As mentioned above, TN-R knockout mice show abnormal PNN staining, with irregular distribution of WFA around soma and dendrites (Brückner et al., 2000;Morawski et al., 2014;Weber et al., 1999).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Brückner et al., 2000
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- Authors
- Br�ckner, G., Grosche, J., Schmidt, S., H�rtig, W., Margolis, R. U., Delpech, B., Seidenbecher, C. I., Czaniera, R., & Schachner, M.
- Venue
- The Journal of Comparative Neurology
- Published
- 2000
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