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Cited by 667Vitamin D Research StudiesBone health and osteoporosis researchVitamin K Research Studies

The DOI matches its Crossref record; 193 of the 205 references it cites were found in a registry or an index.

Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis

Avenell, Alison, Gillespie, William J, Gillespie, Lesley D, O'Connell, Dianne·2009·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd000227.pub3
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Abstract

BACKGROUND: Vitamin D and related compounds have been used to prevent osteoporotic fractures in older people. OBJECTIVES: To determine the effects of vitamin D or related compounds, with or without calcium, for preventing fractures in older people. SEARCH STRATEGY: We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials (The Cochrane Library 2007, Issue 3), MEDLINE, EMBASE, CINAHL, and reference lists of articles. Most recent search: October 2007. SELECTION CRITERIA: Randomised or quasi-randomised trials comparing vitamin D or related compounds, alone or with calcium, against placebo, no intervention, or calcium alone, reporting fracture outcomes in older people. DATA COLLECTION AND ANALYSIS: Two authors independently assessed trial quality, and extracted data. Data were pooled, where admissible, using the fixed-effect model, or random-effects model if heterogeneity between studies appeared high. MAIN RESULTS: Forty-five trials were included. Vitamin D alone appears unlikely to be effective in preventing hip fracture (nine trials, 24,749 participants, RR 1.15, 95% CI 0.99 to 1.33), vertebral fracture (five trials, 9138 participants, RR 0.90, 95% CI 0.42 to 1.92) or any new fracture (10 trials, 25,016 participants, RR 1.01, 95% CI 0.93 to 1.09).Vitamin D with calcium reduces hip fractures (eight trials, 46,658 participants, RR 0.84, 95% CI 0.73 to 0.96). Although subgroup analysis by residential status showed a significant reduction in hip fractures in people in institutional care, the difference between this and the community-dwelling subgroup was not significant (P = 0.15).Overall hypercalcaemia is significantly more common in people receiving vitamin D or an analogue, with or without calcium (18 trials, 11,346 participants, RR 2.35, 95% CI 1.59 to 3.47); this is especially true of calcitriol (four trials, 988 participants, RR 4.41, 95% CI 2.14 to 9.09). There is a modest increase in gastrointestinal symptoms (11 trials, 47,042 participants, RR 1.04, 95% CI 1.00 to 1.08, P = 0.04) and a small but significant increase in renal disease (11 trials, 46,537 participants, RR 1.16, 95% CI 1.02 to 1.33). AUTHORS' CONCLUSIONS: Frail older people confined to institutions may sustain fewer hip fractures if given vitamin D with calcium. Vitamin D alone is unlikely to prevent fracture. Overall there is a small but significant increase in gastrointestinal symptoms and renal disease associated with vitamin D or its analogues. Calcitriol is associated with an increased incidence of hypercalcaemia.

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  1. Chapuy, 1993, Prevention of non vertebral fractures and cortical bone loss in elderly women: a prospective controlled trial using calcium and vitamin D3 supplements [abstract], Osteoporosis International, 3 Suppl 1, 258
  2. Meunier, 2002, A calcium-vitamin D3 combined supplementation is cost-saving for preventing hip fractures in institutionalised elderly women: an economic evaluation from the perspective of seven European countries (Belgium, France, Germany, The Netherlands, Spain, Sweden, United Kingdom), Osteoporosis International, 13, S14
  3. Chapuy, 2002, Combined calcium and vitamin D3 supplementation to prevent hip fracture in elderly women. A confirmatory study: Decalyos II, Osteoporosis International, 13, S25
  4. Bischoff-Ferrari, 2004, Effect of vitamin D3 plus calcium on fall risk in older men and women: a 3-year randomized controlled trial, Journal of Bone and Mineral Research, 19, S57
  5. Krall, 2000, Calcium and vitamin D supplements reduce tooth loss in the elderly, Journal of Bone and Mineral Research, 15, S191
  6. Dukas, 2003, Alfacalcidol reduces the number of fallers and falls in community-dwelling elderly provided a minimum total daily intake of 500mg calcium [abstract], Calcified Tissue International, 72, 371
  7. Dukas, 2006, Reduction of falls and fallers using D-hormone analogs, Osteoporosis International, 17, S122
  8. Dukas, 2003, A significant independent new risk factor for falls in the elderly: a low creatinine clearance of less than 65ml/min, Osteoporosis International, 14, S33
  9. Dukas, 2004, High risk of falls related to low D-hormone syndrome and its treatment with alfacalcidol, Osteoporosis International, 15, S8
  10. Dukas, 2004, Reduction of falls and fallers in high risk patients by D-hormone analogs, Osteoporosis International, 15, S144
  11. Dukas, 2003, Treatment with alfacalcidol significantly decreases the high incidence of fallers and the high risk of falls associated with low creatinine clearance (<65ml/min) in elderly community-dwelling men and women, Osteoporosis International, 14, S33
  12. Dukas, 2004, The low creatinine clearance associated high risk of falls can significantly be treated with alfacalcidol, Journal of Bone and Mineral Research, 19, S95
  13. Flicker L MacInnis R Stein M Scherer S Mead K Nowson C Should all older people in residential care receive vitamin D to prevent falls? Results of a randomised trial [abstract] Journal of Bone and Mineral Research 2004 S99
  14. Flicker, 2004, Should all older people in residential care receive vitamin D to prevent falls? Results of a randomised trial, Journal of Bone and Mineral Research, 19, S99
  15. Gallagher, 1999, Effect of estrogen, calcitriol and a combination of estrogen and calcitriol on bone mineral density and fractures in elderly women, Journal of Bone and Mineral Research, 14, S209
  16. Gallagher, 2003, Calcitriol therapy reduces falls and fractures in elderly women, Calcified Tissue International, 72, 334
  17. Gallagher, 2001, Effect of estrogen, calcitriol or the combination of both on falls and non vertebral fractures in elderly women, Journal of Bone and Mineral Research, 17, S210
  18. Gallagher, 2004, A comparison of estrogen, calcitriol or both therapies on the relationship between serum parathyroid hormone and 25 hydroxy vitamin, Journal of Bone and MIneral Research, 19, S440
  19. Garay Lillo, 1997, Geminis: a prospective, multicentric, randomised study to evaluate the effect of tricalcium phosphate versus tricalcium phosphate plus 25(OH) Vitamin D on the risk of fractures in older women, Geriátrika, 13, 24
  20. Sahota, 2003, A randomised, controlled comparison of different calcium and vitamin D regimes: the NoNOF (Nottingham Neck of Femur) study, Osteoporosis International, 14, S10
  21. Ishida, 2002, A two-year randomized controlled trial of hormone replacement therapy, etidronate, calcitonin, vitamin D, or vitamin K, in women with postmenopausal osteoporosis, Journal of Bone and Mineral Research, 17, S478
  22. Ishida, 2003, Comparative efficacy of hormone replacement therapy, bisphosphonates, calcitonin, vitamin D and vitamin K in postmenopausal women with osteoporosis, Journal of Bone and Mineral Research, 18, S158
  23. Ishida, 2003, Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, vitamin D and vitamin K in postmenopausal osteoporosis, Bone, 33, S220
  24. Ishida, 2000, A one-year randomized controlled trial of hormone replacement therapy, bisphosphonate, calcitonin, vitamin D, and vitamin K, in women with postmenopausal osteoporosis, Journal of Bone and Mineral Research, 15, S310
  25. Ishida, 2002, Effectiveness of hormone replacement therapy, etidronate, calcitonin, vitamin D, and vitamin K in postmenopausal women with osteoporosis [abstract], Bone, 30, 50S
  26. Johansen, 2006, Preventing fractures among older people living in institutional care: a randomised double blind placebo controlled trial of vitamin D supplementation [abstract], Age and Ageing, 35, i41
  27. Lyons, 2006, Preventing fractures among older people living in institutional care: a randomised double blind placebo controlled trial of vitamin D supplementation [abstract], Osteoporosis International, 17, 372
  28. Meyer, 2000, Can vitamin D supplementation reduce the risk of fracture in the elderly? A randomised controlled trial, Osteoporosis International, 11, S114
  29. Nuti, 2005, Efficacy and safety of alfacalcidol compared to vitamin D plus calcium in post menopausal osteoporosis [abstract], Osteoporosis International, 16, S75
  30. Minne, 2000, Vitamin D and calcium supplementation reduces falls in elderly women via improvement of body sway and normalisation of blood pressure; a prospective, randomized, and double-blind study, Osteoporosis International, 11, S115
  31. Pfeifer, 1998, Prevention of falls-related fractures: vitamin D reduces body sway in the elderly - a prospective, randomized, double blind study [abstract], Bone, 23, 1110
  32. Dumville, 2004, Can vitamin D supplementation prevent seasonal affective disorder? A randomised trial among older women, Osteoporosis International, 15, S42
  33. Porthouse, 2005, Randomised controlled trial of calcium and vitamin D supplementation for fracture prevention in primary care, Osteoporosis International, 16, S27
  34. S, 2003, Calcium and vitamin D in primary care. Compliance results from a randomised controlled trial, Osteoporosis International, 14, S8
  35. Grant, 2005, The RECORD trial: an evaluation of calcium and/or vitamin D in the secondary prevention of osteoporotic fractures, Osteoporosis International, 16, S4
  36. Grant, 2004, The Medical Research Council RECORD Trial: an evaluation of calcium and/or vitamin D in the secondary prevention of osteoporotic fractures, Osteoporosis International, 15, S13
  37. Anderson, 2000, Intramuscular vitamin D increased serum 1,25-dihydroxycholecalciferol but did not affect 25-hydroxy-cholecalciferol levels in health older adults [abstract], Journal of Bone and Mineral Research, 15, S315
  38. Anderson, 2004, Effect of annual intramuscular vitamin D3 supplementation on fracture risk in 9440 community-living older people: the Wessex fracture prevention trial [abstract], Journal of Bone and Mineral Research, 19, S57
  39. Raphael, 2000, Tackling the problems of trial management in primary care - experience from the Wessex research network fracture prevention study of annual vitamin D injection in older people [abstract], Osteoporosis International, 11, S63
  40. Smith, 2000, The Wessex research network fracture prevention study - a large pragmatic trial of annual vitamin D injection in older people [abstract], Osteoporosis International, 11, S64
  41. Smith, 2004, Effect of annual intramuscular vitamin D supplementation on fracture risk: population-based, randomised, double-blind, placebo-controlled trial [abstract], Osteoporosis International, 15, S8
  42. Cauley, 2007, Serum 25 hydroxy vitamin D 25(OH) and the risk of hip fracture: the Women's Health Initiative (WHI), Journal of Bone and Mineral Research, 22, S57
  43. Chen, 2007, The effect of calcium plus vitamin D supplement on hip geometric structures: results from the Women's Health Initiative CaD trial, Journal of Bone and Mineral Research, 22, S59
  44. McGowan, 2002, Calcium and vitamin D in the prevention of hip and other fractures: an update on the Women's Health Initiative CaD Trial, Journal of Bone and Mineral Research, 17, S477
  45. Aguado, 2006, The efficacy of two dosing regimens (daily colecalciferol versus cyclical calcidiol) for the prevention of bone mass loss in postmenopausal women with vitamin D insufficiency, Journal of Bone and Mineral Research, 21, S306
  46. Talwar, 2004, Oral vitamin D3 supplementation in postmenopausal African American women, Calcified Tissue International, 74, S102
  47. Talwar, 2004, Oral vitamin D3 supplementation in postmenopausal African American women, Journal of Bone and Mineral Research, 19, S324
  48. Binkley, 2007, Treatment effects of vitamin D3 8400IU once weekly on elderly subjects with vitamin D insufficiency, Osteoporosis International, 18, S118
  49. Kiel, 2004, A higher dose of vitamin D reduces the risk of falls in nursing home residents: a randomized, placebo-controlled, multiple dose study, Journal of Bone and Mineral Research, 19, S462
  50. Cooper, 1999, Vitamin D supplementation and bone mineral density in early postmenopausal women, Journal of Bone and Mineral Research, 14, S538
  51. Harju, 1991, Prevention of bone fractures by annual intramuscular injection of ergocalciferol in the aged, British Journal of Surgery, 78, 1145
  52. Itami, 1982, [Effect of alphacalcidol on osteoporosis - a multicentre double-blind study]. [Japanese], Igaku No Ayumi - Journal of Clinical and Experimental Medicine, 123, 958
  53. Jensen, 1985, Does 1,25(OH)2D3 accelerate spinal bone loss? A controlled therapeutic trial in 70-year old women, Clinical Orthopaedics and Related Research, (192), 215
  54. Patel, 2000, The effect of season and vitamin D supplementation on bone mineral density: a double-blind crossover study, Osteoporosis International, 11, S28
  55. Pedrosa, 2006, Cholecalciferol supplementation reverts 25-hydroxyvitamin D (25OHD) insufficiency and increases lower limb muscle strength (LLMS) in elderly people living in long-stay geriatric care (LSC), Osteoporosis International, 17, S229
  56. Naressi, 2004, Bone markers and bone mineral density after two years treatment with alfacalcidol in high remodeling postmenopausal women with low mineral density, Osteoporosis International, 15, S100
  57. Riera-Espinoza, 2003, Randomized double blind 12 months study of 1mcg/day of alphacalcidol vs placebo in high bone turnover postmenopausal osteoporosis, Bone, 5, S226
  58. Riera, 2002, Randomized double blind twelve months study of 1mcg/day of alphacalcidol vs placebo in high bone turnover postmenopausal women, Journal of Bone and Mineral Research, 17, S276
  59. Zhu, 2006, An RCT of vitamin D or placebo on falls in elderly women with low vitamin D status and a falling history, Journal of Bone and Mineral Research, 21, S60
  60. Zhu, 2006, An RCT of the effects of ergocalciferol and calcium on PTH and bone structure in elderly women with low vitamin D status, Journal of Bone and Mineral Research, 21, S308
  61. Bock, 2007, Effect of alfacalcidol on volumetric bone mineral density measured by pQCT in alendronate-treated postmenopausal women with osteopenia or osteoporosis: 1 year interim analysis of the ALFA study [abstract], Journal of Bone and Mineral Research, 22, S215
  62. Bock, 2006, Effect of alfacalcidol on biochemical bone markers in alendronate-treated postmenopausal women with osteopenia or osteoporosis: 1 year interim analysis of the ALFA study [abstract], Journal of Bone and Mineral Research, 21, S306
  63. Boerst, 2007, Effects of alfacalcidol on bone markers and bone mineral density in alendronate-treated postmenopausal women with osteopenia or osteoporosis: one year interim analysis of the ALFA study [abstract], Osteoporosis International, 18, S90
  64. Fujita, 1989, Clinical evaluation of the effect of calcitriol on osteoporosis. Multicenter double-blind study using alfacalcitol as the control drug, Igaku No Ayumi - Journal of Clinical and Experimental Medicine, 148, 833
  65. Johnell, 2002, Vitamin D treatment best for the frailest to prevent hip fractures? A prospective controlled clinical trial, Journal of Bone and Mineral Research, 16, S180
  66. Lappe, 2007, Calcium and vitamin D supplementation improves bone health in a population-based sample of postmenopausal women [abstract], Journal of Bone and Mineral Research, 22, S320
  67. Lappe, 2005, Population-based evidence that serum 25(OH)D levels below 80nmol/L reflect vitamin D deficiency [abstract], Journal of Bone and Mineral Research, 20, S379
  68. Matsumoto, 2004, A new active vitamin D, ED-71, increases bone mass in osteoporotic subjects under vitamin D supply, Journal of Bone and Mineral Research, 19, S181
  69. Karkkainen, 2007, Vitamin-D 800IU/day + calcium supplementation decreases the risk of falling among postmenopausal ambulatory women - a population-based, randomized 3-year study (OSTPRE-FPS) [abstract], Journal of Bone and Mineral Research, 22, S131
  70. Salovaara, 2007, Effect of vitamin-D3 and calcium on fracture risk in 65-71 year old women in a 3-year randomized clinical trial - preliminary results of the OSTPRE-Fracture Prevention Study [abstract], Journal of Bone and Mineral Research, 22, S76
  71. Minne, 2006, Effects of vitamin D and calcium supplementation on falls and parameters of muscle function: a prospective, randomized, double-blind multicenter study [abstract], Osteoporosis International, 17, S212
  72. Minne, 2006, Effects of vitamin D and calcium supplementation on falls and parameters of muscle-function - a prospective, randomized, double-blind multi-center study [abstract], Osteoporosis International, 17, S21
  73. Pfeifer, 2004, Effects of vitamin D and calcium supplementation on falls and parameters of muscle function: a prospective randomized, double-blind multi-centre study [abstract], Journal of Bone and Mineral Research, 19, S58
  74. Pfeifer, 2005, Effects of vitamin D and calcium supplementation on falls and parameters of muscle function - a prospective, randomized, double-blind multi-center study [abstract], Osteoporosis International, 16, S45
  75. Higgins JPT Green S Selection bias. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]; Section 6.3 In: The Cochrane Library, Issue 4, 2006. Chichester, UK: John Wiley & Sons, Ltd
  76. Higgins JPT Green S Cluster-randomized trials. Cochrane Handbook for Systematic Reviews of Interventions 4.2.6 [updated September 2006]; Section 8.11.2 In: The Cochrane Library, Issue 4, 2006. Chichester, UK: John Wiley & Sons, Ltd
  77. Gillespie, 1996, Vitamin D and Vitamin D analogues in the prevention of fractures in involutional and post-menopausal osteoporosis, Cochrane Database of Systematic Reviews
  78. Gillespie, 2000, Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis, Cochrane Database of Systematic Reviews

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Metadata

Authors
Avenell, A., Gillespie, W. J., Gillespie, L. D., & O'Connell, D.
Affiliations
  • University of Aberdeen (GB)
  • University of Hull (GB)
  • University of Otago (NZ)
ORCID
Avenell, Alison
Venue
Cochrane Database of Systematic Reviews
Publisher
John Wiley & Sons, Ltd
Published
2009-04-15
Issue
2
Pages
CD000227-CD000227
ISSN
1361-6137 (ISSN-L)
DOI
10.1002/14651858.cd000227.pub3
OpenAlex
W1564323166
Cited by
667
References
205
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 14 · 2018: 9 · 2017: 20 · 2016: 32 · 2015: 42 · 2014: 56 · 2013: 57 · 2012: 54
Type
reference entry
Language
en
Update notices
new_version (2014-04-14)
Open access
closed
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords
vitamin D, vitamin D analogs, osteoporosis, postmenopausal osteoporosis, involutional osteoporosis, fracture prevention, hip fracture, vertebral fractures, calcium supplementation, hypercalcemia, 1,25-dihydroxyvitamin D3, community-dwelling older adults, fall prevention, falls in older adults
MeSH terms
Aged, Calcitriol, Female, Humans, Hydroxycholecalciferols, Male, Osteoporosis, Vitamin D, Vitamins, Osteoporosis, Postmenopausal, Randomized Controlled Trials as Topic, Frail Elderly, Dietary Supplements, Bone Density Conservation Agents, Fractures, Bone

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