Epidemiology and outcomes of osteoporotic fractures

Cummings, Steven R; Melton, L Joseph

doi:10.1016/s0140-6736(02)08657-9

Cited by 3,821Bone health and osteoporosis researchHip and Femur FracturesBone fractures and treatments

Epidemiology and outcomes of osteoporotic fractures

Cummings, Steven R, Melton, L Joseph·2002·The Lancet

DOI 10.1016/s0140-6736(02)08657-9

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Abstract

Bone mass declines and the risk of fractures increases as people age, especially as women pass through the menopause. Hip fractures, the most serious outcome of osteoporosis, are becoming more frequent than before because the world's population is ageing and because the frequency of hip fractures is increasing by 1-3% per year in most areas of the world. Rates of hip fracture vary more widely from region to region than does the prevalence of vertebral fractures. Low bone density and previous fractures are risk factors for almost all types of fracture, but each type of fracture also has its own unique risk factors. Prevention of fractures with drugs could potentially be as expensive as medical treatment of fractures. Therefore, epidemiological research should be done and used to identify individuals at high-risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need.

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Bone homoeostasis relies on a dynamic balance between osteogenesis, carried out by osteoblasts, and osteoclastogenesis, carried out by osteoclasts.
“Bone homoeostasis relies on a dynamic balance between osteogenesis, carried out by osteoblasts, and osteoclastogenesis, carried out by osteoclasts.93”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [93]

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Authors: Cummings, S. R., & Melton, L. J.
Affiliations: University of California, San Francisco (US)
Mayo Clinic (US)
Corresponding author: Cummings, Steven R
ORCID: Cummings, Steven R
Venue: The Lancet
Publisher: Elsevier BV
Published: 2002-05
Volume: 359
Issue: 9319
Pages: 1761-1767
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(02)08657-9
OpenAlex: W2108063837
Cited by: 3,821
References: 107
Citations by year: 2026: 124 · 2025: 164 · 2024: 169 · 2023: 152 · 2022: 155 · 2021: 162 · 2020: 197 · 2019: 160 · 2018: 170 · 2017: 180 · 2016: 179 · 2015: 199 · 2014: 171 · 2013: 190 · 2012: 185
FWCI: 14.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AM35584)
National Institute on Aging (AG 04875, AG05394, P01AG004875, AG-05407)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR35583, AR 35582, R01AR035582, R01AR035583)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Surgery › Hip and Femur Fractures
Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Keywords: osteoporotic fractures, hip fracture, vertebral fractures, fracture risk factors, osteopenia, menopause, population aging, fracture prevention, fracture epidemiology, fracture outcomes, resource allocation
MeSH terms: Aged, Aged, 80 and over, Female, Hip Fractures, Humans, Male, Middle Aged, Osteoporosis, Population Surveillance, Risk Factors, Prevalence, Survival Rate, Age Distribution, Sex Distribution

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Epidemiology and outcomes of osteoporotic fractures

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