Cited by 118Down syndrome and intellectual disability researchSchizophrenia research and treatmentBehavioral and Psychological Studies

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Antipsychotic medication for challenging behaviour in people with learning disability

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Brylewski, Jane, Duggan, Lorna·2004·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd000377.pub2PMC PMC12334078

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Abstract

BACKGROUND: The term 'challenging behaviour', in the absence of psychiatric disorder, encompasses a wide range of behaviours that may be harmful to people or property, may be difficult to manage and may limit access to community facilities. Antipsychotic medications have been used to modify such behaviours in people with learning disability, but there is little evidence to suggest that the benefits outweigh the risks. OBJECTIVES: To determine the effectiveness of antipsychotic medication for people with learning disability and challenging behaviour without additional mental illness. SEARCH STRATEGY: Biological Abstracts, the Cochrane Library, EMBASE, MEDLINE, PsycINFO and BIOSIS were searched. Further references were sought from published trials and pharmaceutical companies. Trials were reliably identified and data extracted. SELECTION CRITERIA: All randomised controlled trials of antipsychotic medication versus placebo. DATA COLLECTION AND ANALYSIS: Reviewers independently evaluated and analysed data on an intention to treat basis. Data were evaluated at 4, 8 and 12 weeks as longer follow-up data were not available. Reviewers assumed that those subjects lost to follow-up had a bad outcome. MAIN RESULTS: Only nine randomised controlled trials could be included in the analyses. These provided no evidence of whether antipsychotic medication helps or harms adults with learning disability and challenging behaviour. REVIEWERS' CONCLUSIONS: There are limited data on this important issue and more research is urgently needed.

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Authors: Brylewski, J., & Duggan, L.
Affiliations: Oxford University Hospitals NHS Trust (GB)
St Andrew’s Hospital (AU)
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2004-07-19
Volume: 2009
Issue: 1
Pages: CD000377-CD000377
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd000377.pub2
PMC: PMC12334078
OpenAlex: W2108463235
Cited by: 118
References: 73
Citations by year: 2026: 2 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 9
FWCI: 0.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords: antipsychotic drugs, behavioral problems, learning disabilities, adults with intellectual disabilities, adverse effects, placebo comparison
MeSH terms: Adult, Behavioral Symptoms, Dangerous Behavior, Humans, Learning Disabilities, Risk, Antipsychotic Agents, Randomized Controlled Trials as Topic

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