Efficacy of atypical antipsychotic medication in the management of behaviour problems in children with intellectual disabilities and borderline intelligence: A systematic review
Abstract
The use of medications to manage problem behaviours is widespread. However, robust evidence to support their use seems to be lacking. The aim was to review research evidence into the efficacy of atypical antipsychotic medication in managing problem behaviour in children with intellectual disabilities and borderline intelligence. A systematic review was conducted for placebo-controlled randomised double-blind trials. The included studies (N = 6) showed that risperidone was significantly more effective than placebo in managing problem behaviours. However, most studies highlighted adverse events primarily somnolence and weight gain. There is now some evidence in favour of the use of risperidone. However, because of possible adverse events, these medications have to be used with caution.
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There is some evidence for the effectiveness of risperidone in addressing challenging behaviour in children with autism spectrum disorder, including those with intellectual disability.
“There is some evidence for the effectiveness of risperidone in addressing challenging behaviour in children with autism spectrum disorder, including those with intellectual disability (Unwin 2011; National Collaborating Centre for Mental Health 2012).”
From Interventions for challenging behaviour in intellectual disability (2014) · cites this paper as Unwin 2011
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- Authors
- Unwin, G. L., & Deb, S.
- Affiliations
- University of Birmingham (GB)
- Corresponding author
- Unwin, Gemma L.
- Venue
- Research in Developmental Disabilities
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 32
- Issue
- 6
- Pages
- 2121-2133
- ISSN
- 0891-4222 (ISSN-L)
- OpenAlex
- W2004842910
- Cited by
- 62
- References
- 44
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 11 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 5
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Research in Developmental Disabilities (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- atypical antipsychotics, risperidone, behavioral problems, intellectual disability, borderline intellectual functioning, children, drug efficacy, adverse events, sleepiness, weight gain
- MeSH terms
- Child, Child Behavior Disorders, Humans, Intellectual Disability, Antipsychotic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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What counts as a claim ›How we measure confidence ›How we check this ›
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