Oral contraceptives for pain associated with endometriosis
Abstract
Background Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The modern oral contraceptive pill is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited. Objectives To assess the effects of the oral contraceptive pill (OCP) in comparison to other treatments for painful symptoms of endometriosis in women of reproductive age. Search strategy We searched the Menstrual Disorders and Subfertility Group Specialised Register of controlled trials; Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 3, 2006); MEDLINE (January 1966 to September 2006); EMBASE (1980 to September 2006); National Research Register; and reference lists of articles. Selection criteria All truly randomised controlled trials of the use of oral contraceptive pills in the treatment of women of reproductive age with symptoms ascribed to the diagnosis of endometriosis and made visually at surgical procedure were included. Data collection and analysis Study quality assessment and data extraction were carried out independently by two review authors. One of the assessors was an expert in the content matter. We contacted study authors for additional information. Main results Only one study met the inclusion criteria, in which a total of 57 women were allocated to two groups to compare an OCP to a GnRH analogue. Methods of randomisatio…
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Combined oral contraceptives are not approved for endometriosis in most countries and lack a solid body of supportive clinical trial evidence.
“Combined oral contraceptives, whereas widely used to manage symptoms of endometriosis, are not approved for this indication in most countries and lack a solid body of supportive clinical trial evidence”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Davis et al., 2007
Cites
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Self-citationVercellini, P., De Giorgi, O., Mosconi, P., Stellato, G., Vicentini, S., & Crosignani, P. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02951-x · Cited by 180 · see citing works
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Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., & Seitz, C. (2010) · Human Reproduction · doi:10.1093/humrep/dep469 · Cited by 381 · see citing works
Endometriosis: an overview of Cochrane Reviews
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Progestagens and anti-progestagens for pain associated with endometriosis
Brown, J., Kives, S., & Akhtar, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002122.pub2 · Cited by 250 · see citing works
Oral contraceptives for pain associated with endometriosis
Brown, J., Crawford, T. J., Datta, S., & Prentice, A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001019.pub3 · Cited by 199 · see citing works
Self-citationGonadotrophin-releasing hormone analogues for pain associated with endometriosis
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Gonadotrophin-releasing hormone analogues for pain associated with endometriosis
Prentice, A., Deary, A., Goldbeck-Wood, S., Farquhar, C., & Smith, S. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000346 · Cited by 116 · see citing works
Self-citationRetractedJensen, J. T., Schlaff, W., & Gordon, K. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.03.012 · Cited by 113 · see citing works
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- Authors
- Davis, L.-J., Kennedy, S. S., Moore, J., & Prentice, A.
- Affiliations
- Derriford Hospital (GB)
- John Radcliffe Hospital (GB)
- Rosie Hospital (GB)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2007-07-18
- Issue
- 3
- Pages
- CD001019-CD001019
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W4230900835
- Cited by
- 65
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Update notices
- new_version (2018-05-22)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, dysmenorrhea, dyspareunia, oral contraceptives, GnRH analogues, pain management, amenorrhea, infertility, women of reproductive age, treatment efficacy comparison, endometriosis surgery, menstrual disorders, subfertility, underpowered trials, trial quality assessment
- MeSH terms
- Contraceptives, Oral, Endometriosis, Female, Humans, Pelvic Pain
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