The DOI matches its Crossref record; 131 of the 133 references it cites were found in a registry or an index.
Interventions for paracetamol (acetaminophen) overdose
Open accessAbstract
BackgroundParacetamol (acetaminophen) is the most widely used non-prescription analgesic in the world.Paracetamol is commonly taken in overdose either deliberately or unintentionally.In high-income countries, paracetamol toxicity is a common cause of acute liver injury.There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person.These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites. ObjectivesTo assess the benefits and harms of interventions for paracetamol overdosage irrespective of the cause of the overdose. Search methodsWe searched The Cochrane Hepato-Biliary Group Controlled Trials Register (January 2017), CENTRAL (2016, Issue 11),
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“Activated charcoal binds paracetamol and thus may reduce the amount of paracetamol absorbed from the gastrointestinal tract [94].”
From Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (2023) · cites this paper as [94]
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“Since acetylcysteine has become standard treatment, deaths are rare, less than 1% in most cohorts [94].”
From Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease (2023) · cites this paper as [94]
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Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
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Metadata
- Authors
- Chiew, A. L., Gluud, C., Brok, J., & Buckley, N. A.
- Affiliations
- The University of Sydney (AU)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- University of Sydney; Department of Pharmacology; Camperdown NSW Australia
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2018-02-23
- Volume
- 2018
- Issue
- 2
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W3183688590
- Cited by
- 170
- References
- 133
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 18 · 2023: 27 · 2022: 32 · 2021: 24 · 2020: 15 · 2019: 14 · 2018: 4
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
- Keywords
- acetaminophen overdose, acetaminophen toxicity, acute liver injury, decontamination, paracetamol removal, analgesic overdose, therapeutic interventions
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