Cited by 171Poisoning and overdose treatmentsDrug-Induced Hepatotoxicity and ProtectionParaquat toxicity studies and treatments

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Interventions for paracetamol (acetaminophen) overdose

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Chiew, Angela L, Gluud, Christian, Brok, Jesper, Buckley, Nick A·2018·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd003328.pub3

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Abstract

BackgroundParacetamol (acetaminophen) is the most widely used non-prescription analgesic in the world.Paracetamol is commonly taken in overdose either deliberately or unintentionally.In high-income countries, paracetamol toxicity is a common cause of acute liver injury.There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person.These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites. ObjectivesTo assess the benefits and harms of interventions for paracetamol overdosage irrespective of the cause of the overdose. Search methodsWe searched The Cochrane Hepato-Biliary Group Controlled Trials Register (January 2017), CENTRAL (2016, Issue 11),

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Authors: Chiew, A. L., Gluud, C., Brok, J., & Buckley, N. A.
Affiliations: The University of Sydney (AU)
Copenhagen University Hospital (DK)
Rigshospitalet (DK)
University of Sydney; Department of Pharmacology; Camperdown NSW Australia
ORCID: Chiew, Angela L
Gluud, Christian
Brok, Jesper
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2018-02-23
Volume: 2018
Issue: 2
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd003328.pub3
OpenAlex: W3183688590
Cited by: 170
References: 133
Citations by year: 2026: 14 · 2025: 22 · 2024: 18 · 2023: 27 · 2022: 32 · 2021: 24 · 2020: 15 · 2019: 14 · 2018: 4
FWCI: 3.52
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
Topics: Health Sciences › Medicine › Emergency Medicine › Poisoning and overdose treatments
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
Keywords: acetaminophen overdose, acetaminophen toxicity, acute liver injury, decontamination, paracetamol removal, analgesic overdose, therapeutic interventions

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