The DOI matches its Crossref record; 79 of the 81 references it cites were found in a registry or an index.
Exercise based rehabilitation for heart failure
Open accessAbstract
BACKGROUND: The prevalence of chronic heart failure is increasing, and increases with increasing age. Major symptoms include breathlessness and restricted activities of daily living due to reduced functional capacity, which in turn affects quality of life. Exercise training has been shown to be effective in patients with coronary heart disease and has been proposed as an intervention to improve exercise tolerance in patients with heart failure. OBJECTIVES: To determine the effectiveness of exercise based interventions compared with usual medical care on the mortality, morbidity, exercise capacity and health related quality of life, of patients with heart failure. SEARCH STRATEGY: We searched the Cochrane Controlled Trials Register (The Cochrane Library Issue 2, 2001), MEDLINE (2000 to March 2001), EMBASE (1998 to March 2001), CINAHL (1984 to March 2001) and reference lists of articles. We also sought advice from experts. SELECTION CRITERIA: RCTs of exercise based interventions. The comparison group was usual medical care as defined by the study, or placebo. Adults of all ages with chronic heart failure. Only those studies with criteria for diagnosis of heart failure (based on clinical findings or objective indices) have been included. DATA COLLECTION AND ANALYSIS: Studies were selected, and data were abstracted, independently by two reviewers. Authors were contacted where possible to obtain missing information. MAIN RESULTS: Twenty-nine studies met the inclusion criteria, with 1126 patients randomised. The majority of studies included both patients with primary and secondary heart failure, NYHA class II or III. None of the studies specifically examined the effect of exercise training on mortality and morbidity as most were of short duration. Exercise training significantly increased VO(2) max by (WMD random effects model) 2.16 ml/kg/min (95% CI 2.82 to 1.49), exercise duration increased by 2.38 minutes (95% CI 2.85 to 1.9), work capacity by 15.1 Watts (95% CI 17.7 to 12.6) and distance on the six minute walk by 40.9 metres (95% CI 64.7 to 17.1). Improvements in VO(2) max were greater for training programmes of greater intensity and duration. HRQoL improved in the seven of nine trials that measured this outcome. REVIEWERS' CONCLUSIONS: Exercise training improves exercise capacity and quality of life in patients mild to moderate heart failure in the short term. There is currently no information regarding the effect of exercise training on clinical outcomes. The findings are based on small-scale trials in patients who are unrepresentative of the total population of patients with heart failure. Other groups (more severe patients, the elderly, women) may also benefit. Large-scale pragmatic trials of exercise training of longer duration, recruiting a wider spectrum of patients are needed to address these issues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The same is also true for patients with chronic heart failure and reduced left ventricular function, New York Heart Association class II-IV symptoms, and treated with optimal, guideline-based background heart failure therapy.342”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [342]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Systematic Reviews: Identifying relevant studies for systematic reviews
Dickersin, K., Scherer, R. W., & Lefebvre, C. (1994) · BMJ · doi:10.1136/bmj.309.6964.1286 · Cited by 2,255
Guidelines for the diagnosis and treatment of chronic heart failure
Remme, W. J. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2783 · Cited by 1,595
An overview of randomized trials of rehabilitation with exercise after myocardial infarction.
O'Connor, G. T., Buring, J. E., Yusuf, S., Goldhaber, S. Z., Olmstead, E. M., Paffenbarger, R. S., & Hennekens, C. H. (1989) · Circulation · doi:10.1161/01.cir.80.2.234 · Cited by 1,414
Variance imputation for overviews of clinical trials with continuous response
Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391
Belardinelli, R., Georgiou, D., Cianci, G., & Purcaro, A. (1999) · Circulation · doi:10.1161/01.cir.99.9.1173 · Cited by 1,099
Hambrecht, R., Fiehn, E., Weigl, C., Gielen, S., Hamann, C., Kaiser, R., Yu, J., Adams, V., Niebauer, J., & Schuler, G. C. (1998) · Circulation · doi:10.1161/01.cir.98.24.2709 · Cited by 963
Coats, A. J. S., Adamopoulos, S. N., Radaelli, A., McCance, A. J., Meyer, T. E., Bernardi, L., Soldà, P. L., Davey, P. P., ORMEROD, O. J. M., & Forfar, C. (1992) · Circulation · doi:10.1161/01.cir.85.6.2119 · Cited by 953
Self-citationCowie, M., Struthers, A. D., Wood, D. A., Coats, A. J. S., Thompson, S. G., Poole-Wilson, P. A., & Sutton, G. C. (1997) · The Lancet · doi:10.1016/s0140-6736(97)06031-5 · Cited by 869
Self-citationEpidemiology, aetiology, and prognosis of heart failure
McMurray, J. J. V., & Stewart, S. (2000) · Heart · doi:10.1136/heart.83.5.596 · Cited by 807
Research works printed but not linked: 4
- Ponikowski, 1997, Exercise rehabilitation in patients with moderate-severe chronic heart failure., Kardiologia Polska, 47, 291
- Dziekan, 1998, Effects of exercise training on limb blood flow in patients with reduced ventricular function, American Heart Journal, 136, 22, 10.1016/S0002-8703(98)70177-2 · DOI
- Jolliffe, 2001, Exercise based rehabilitation for coronary heart disease (Cochrane Review), The Cochrane Library
- NHS Centre for Reviews and Dissemination Cardiac Rehabilitation Effective Health Care Bulletin 1998 4
Cited by
Sorted by citations
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
Self-citationESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,535
2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease
Pelliccia, A., Sharma, S., Gati, S., Bäck, M., Börjesson, M., Caselli, S., Collet, J.-P., Corrado, D., Drezner, J. A., Halle, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa605 · Cited by 1,958
Self-citationExercise-based rehabilitation for heart failure
Taylor, R. S., Sagar, V. A., Davies, E. J., Briscoe, S., Coats, A. J., Dalal, H., Lough, F., Rees, K., Singh, S. J., & Mordi, I. R. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003331.pub4 · Cited by 871
Self-citationFlynn, K. E., Piña, I. L., Whellan, D. J., Lin, L., Blumenthal, J. A., Ellis, S. J., Fine, L. J., Howlett, J. G., Keteyian, S. J., Kitzman, D. W., et al. (2009) · JAMA · doi:10.1001/jama.2009.457 · Cited by 737
Metadata
- Authors
- Rees, K., Taylor, R. R., Singh, S., Coats, A. J., & Ebrahim, S.
- Affiliations
- University of Bristol (GB)
- University of Exeter (GB)
- Glenfield Hospital (GB)
- The University of Sydney (AU)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Rees, Karen
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- John Wiley & Sons, Ltd
- Published
- 2004-07-19
- Issue
- 3
- Pages
- CD003331-CD003331
- ISSN
- 1361-6137 (ISSN-L)
- PMC
- PMC4164468
- OpenAlex
- W4248193413
- Cited by
- 253
- References
- 81
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 24 · 2022: 8 · 2021: 13 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 10 · 2012: 8
- Type
- reference entry
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure, exercise training, cardiac rehabilitation, exercise capacity, VO2max, health-related quality of life, 6-minute walk distance, mortality, morbidity, training intensity and duration, NYHA functional class
- MeSH terms
- Cardiac Output, Low, Chronic Disease, Exercise Therapy, Heart Failure, Humans, Quality of Life, Randomized Controlled Trials as Topic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
