Cited by 876Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional DevelopmentPsychological Treatments and Assessments

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Cognitive behavioural therapy for anxiety disorders in children and adolescents

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James, Anthony C, James, Georgina, Cowdrey, Felicity A, Soler, Angela, Choke, Aislinn·2015·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd004690.pub4PMC PMC6491167

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Abstract

BACKGROUND: A previous Cochrane review (James 2005) showed that cognitive behavioural therapy (CBT) was effective in treating childhood anxiety disorders; however, questions remain regarding (1) the relative efficacy of CBT versus non-CBT active treatments; (2) the relative efficacy of CBT versus medication and the combination of CBT and medication versus placebo; and (3) the long-term effects of CBT. OBJECTIVES: To examine (1) whether CBT is an effective treatment for childhood and adolescent anxiety disorders in comparison with (a) wait-list controls; (b) active non-CBT treatments (i.e. psychological placebo, bibliotherapy and treatment as usual (TAU)); and (c) medication and the combination of medication and CBT versus placebo; and (2) the long-term effects of CBT. SEARCH METHODS: Searches for this review included the Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Depression, Anxiety and Neurosis Group Register, which consists of relevant randomised controlled trials from the bibliographic databases－The Cochrane Library (1970 to July 2012), EMBASE, (1970 to July 2012) MEDLINE (1970 to July 2012) and PsycINFO (1970 to July 2012). SELECTION CRITERIA: All randomised controlled trials (RCTs) of CBT versus waiting list, active control conditions, TAU or medication were reviewed. All participants must have met the criteria of the Diagnostic and Statistical Manual (DSM) or the International Classification of Diseases (ICD) for an anxiety diagnosis, excluding simple phobia, obsessive-compulsive disorder, post-traumatic stress disorder and elective mutism. DATA COLLECTION AND ANALYSIS: The methodological quality of included trials was assessed by three reviewers independently. For the dichotomous outcome of remission of anxiety diagnosis, the odds ratio (OR) with 95% confidence interval (CI) based on the random-effects model, with pooling of data via the inverse variance method of weighting, was used. Significance was set at P < 0.05. Continuous data on each child's anxiety symptoms were pooled using the standardised mean difference (SMD). MAIN RESULTS: Forty-one studies consisting of 1806 participants were included in the analyses. The studies involved children and adolescents with anxiety of mild to moderate severity in university and community clinics and school settings. For the primary outcome of remission of any anxiety diagnosis for CBT versus waiting list controls, intention-to-treat (ITT) analyses with 26 studies and 1350 participants showed an OR of 7.85 (95% CI 5.31 to 11.60, Z = 10.26, P < 0.0001), but with evidence of moderate heterogeneity (P = 0.04, I² = 33%). The number needed to treat (NNT) was 6.0 (95% CI 7.5 to 4.6). No difference in outcome was noted between individual, group and family/parental formats. ITT analyses revealed that CBT was no more effective than non-CBT active control treatments (six studies, 426 participants) or TAU in reducing anxiety diagnoses (two studies, 88 participants). The few controlled follow-up studies (n = 4) indicate that treatment gains in the remission of anxiety diagnosis are not statistically significant. AUTHORS' CONCLUSIONS: Cognitive behavioural therapy is an effective treatment for childhood and adolescent anxiety disorders; however, the evidence suggesting that CBT is more effective than active controls or TAU or medication at follow-up, is limited and inconclusive.

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Authors: James, A. C., James, G., Cowdrey, F. A., Soler, A., & Choke, A.
Affiliations: Warneford Hospital (GB)
Sunderland Royal Hospital (GB)
University of Bath (GB)
ORCID: James, Anthony C
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2015-02-18
Volume: 2020
Issue: 11
Pages: CD004690-CD004690
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd004690.pub4
PMC: PMC6491167
OpenAlex: W1922301328
Cited by: 876
References: 252
Citations by year: 2026: 6 · 2025: 22 · 2024: 39 · 2023: 55 · 2022: 69 · 2021: 78 · 2020: 70 · 2019: 76 · 2018: 78 · 2017: 54 · 2016: 60 · 2015: 68
FWCI: 11.26
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Academy of Child and Adolescent Psychiatry
National Institute of Mental Health
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
Keywords: cognitive behavioral therapy, childhood anxiety disorders, adolescent anxiety disorders, anxiety remission, long-term treatment outcomes, medication adherence, relapse, treatment discontinuation, bibliotherapy, usual care, school-based treatment, waitlist control, children and adolescents, anxiety symptoms, relapse prevention
MeSH terms: Adolescent, Anxiety Disorders, Child, Humans, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic

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