The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Smoking cessation interventions for smokers with current or past depression
Open accessAbstract
BACKGROUND: Individuals with current or past depression are often smokers who are more nicotine dependent, more likely to suffer from negative mood changes after nicotine withdrawal, and more likely to relapse to smoking after quitting than the general population, which contributes to their higher morbidity and mortality from smoking-related illnesses. It remains unclear what interventions can help them to quit smoking. OBJECTIVES: To evaluate the effectiveness of smoking cessation interventions, with and without specific mood management components, in smokers with current or past depression. SEARCH METHODS: In April 2013, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, other reviews, and asked experts for information on trials. SELECTION CRITERIA: Criteria for including studies in this review were that they had to be randomised controlled trials (RCTs) comparing smoking cessation interventions in adult smokers with current or past depression. Depression was defined as major depression or depressive symptoms. We included studies where subgroups of participants with depression were identified, either pre-stated or post hoc. The outcome was abstinence from smoking after six months or longer follow-up. We preferred prolonged or continuous abstinence and biochemically validated abstinence where available. DATA COLLECTION AND ANALYSIS: When possible, we estimated pooled risk ratios (RRs) with the Mantel-Haenszel method (fixed-effect model). We also performed subgroup analyses, by length of follow-up, depression measurement, depression group in study, antidepressant use, published or unpublished data, format of intervention, level of behavioural support, additional pharmacotherapy, type of antidepressant medication, and additional nicotine replacement therapy (NRT). MAIN RESULTS: Forty-nine RCTs were included of which 33 trials investigated smoking cessation interventions with specific mood management components for depression. In smokers with current depression, meta-analysis showed a significant positive effect for adding psychosocial mood management to a standard smoking cessation intervention when compared with standard smoking cessation intervention alone (11 trials, N = 1844, RR 1.47, 95% CI 1.13 to 1.92). In smokers with past depression we found a similar effect (13 trials, N = 1496, RR 1.41, 95% CI 1.13 to 1.77). Meta-analysis resulted in a positive effect, although not significant, for adding bupropion compared with placebo in smokers with current depression (5 trials, N = 410, RR 1.37, 95% CI 0.83 to 2.27). There were not enough trial data to evaluate the effectiveness of fluoxetine and paroxetine for smokers with current depression. Bupropion (4 trials, N = 404, RR 2.04, 95% CI 1.31 to 3.18) might significantly increase long-term cessation among smokers with past depression when compared with placebo, but the evidence for bupropion is relatively weak due to the small number of studies and the post hoc subgroups for all the studies. There were not enough trial data to evaluate the effectiveness of fluoxetine, nortriptyline, paroxetine, selegiline, and sertraline in smokers with past depression.Twenty-three of the 49 trials investigated smoking cessation interventions without specific components for depression. There was heterogeneity between the trials which compared psychosocial interventions with standard smoking cessation counselling for both smokers with current and past depression. Therefore, we did not estimate a pooled effect. One trial compared nicotine replacement therapy (NRT) versus placebo in smokers with current depression and found a positive, although not significant, effect (N = 196, RR 2.64, 95% CI 0.93 to 7.45). Meta-analysis also found a positive, although not significant, effect for NRT versus placebo in smokers with past depression (3 trials, N = 432, RR 1.17, 95% CI 0.85 to 1.60). Three trials compared other pharmacotherapy versus placebo and six trials compared other interventions in smokers with current or past depression. Due to heterogeneity between the interventions of the included trials we did not estimate pooled effects. AUTHORS' CONCLUSIONS: Evidence suggests that adding a psychosocial mood management component to a standard smoking cessation intervention increases long-term cessation rates in smokers with both current and past depression when compared with the standard intervention alone. Pooled results from four trials suggest that use of bupropion may increase long-term cessation in smokers with past depression. There was no evidence found for the use of bupropion in smokers with current depression. There was not enough evidence to evaluate the effectiveness of the other antidepressants in smokers with current or past depression. There was also not enough evidence to evaluate the group of trials that investigated interventions without specific mood management components for depression, including NRT and psychosocial i
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“given evidence that mood management improves smoking abstinence compared with standard smoking cessation support alone [35].”
From intEgrating Smoking Cessation treatment As part of usual Psychological care for dEpression and anxiety (ESCAPE): A randomised and controlled, multi-centre, acceptability and feasibility trial with nested qualitative methods (2025) · cites this paper as [35]
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In the citing paper
“The population was representative of IAPT service users in sex, age and education and participants with common mental illness from other RCTs of smoking cessation interventions [35].”
From intEgrating Smoking Cessation treatment As part of usual Psychological care for dEpression and anxiety (ESCAPE): A randomised and controlled, multi-centre, acceptability and feasibility trial with nested qualitative methods (2025) · cites this paper as [35]
Experimental — accuracy not yet measuredIn the citing paper
“van der Meer and colleagues conducted a Cochrane review of smoking cessation treatments for people with current and historical depression [21] and found that adding psychosocial mood management to usual smoking cessation treatment (e.g., nicotine replacement therapy) moderately increased cessation rates when compared to usual smoking treatment alone (risk ratio of 1.47; 95% confidence interval 1.13 to 1.92) [21],”
In the citing paper
“found that adding psychosocial mood management to usual smoking cessation treatment (e.g., nicotine replacement therapy) moderately increased cessation rates when compared to usual smoking treatment alone (risk ratio of 1.47; 95% confidence interval 1.13 to 1.92) [21]”
In the citing paper
“Studies in patients with severe mental disorders or alcoholism have shown that treating addiction and mental health in parallel results in meaningful improvements in both [17–21].”
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“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript for smokers with psychiatric histories such as mood management counseling for depressed smokers (Hall et al., 1994, 2006; van der Meer et al., 2013).”
Becoña, E., Martínez-Vispo, C., Senra, C., López‐Durán, A., Rodríguez‐Cano, R., & del Río, E. F. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1301-7 · Cited by 25
“Recently, van der Meer and colleagues [25] reviewed 33 trials that included smoking cessation interventions with specific mood management components.”
BackgroundBehavioural interventions for smoking cessation: an overview and network meta-analysis
Hartmann‐Boyce, J., Fanshawe, T. R., Lindson, N., Livingstone‐Banks, J., Ordóñez-Mena, J. M., & Aveyard, P. N. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013229 · Cited by 24
Rapid relapse to smoking following hospital discharge
Mussulman, L. M., Scheuermann, T. S., Faseru, B., Nazir, N., & Richter, K. P. (2019) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2019.100891 · Cited by 22
“Among smokers with current and past depression, a meta-analysis demonstrated increased cessation rates for interventions with a psychosocial mood management component compared to those without (van der Meer et al., 2013).”
BackgroundPharmacological interventions for smoking cessation: an overview of reviews
Cahill, K., Lancaster, T., & Perera, R. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009329 · Cited by 23
Brose, L. S., Simonavičius, E., & McNeill, A. D. (2017) · Psychological Medicine · doi:10.1017/s0033291717002021 · Cited by 22
“Pharmacotherapies were also limited and no study tested varenicline (Cahill et al. 2016) cytisine (Cahill et al. 2016) or bupropion (Tsoi et al. 2013; van der Meer et al. 2013; Hughes et al. 2014), which have all shown effectiveness.”
BackgroundZarghami, M., Taghizadeh, F., Sharifpour, A., & Alipour, A. (2018) · PubMed Central · doi:10.22122/ahj.v10i3.600 · Cited by 22
Petroulia, I., Kyriakos, C. N., Papadakis, S., Tzavara, C., Filippidis, F. T., Girvalaki, C., Peleki, T., Katsaounou, P. A., McNeill, A. D., Mons, U., et al. (2019) · Tobacco Induced Diseases · doi:10.18332/tid/98965 · Cited by 21
Socioeconomic Disparities in Smoking Among U.S. Adults With Depression, 2005–2014
Weinberger, A. H., Bandiera, F. C., Leventhal, A. M., Dierker, L., Gbedemah, M., Tidey, J. W., & Goodwin, R. D. (2018) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2018.02.008 · Cited by 20
Camenga, D. R., & Klein, J. D. (2016) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2016.02.003 · Cited by 20
“A metaanalysis of smoking cessation trials in adults with depression, found that the addition of psychosocial mood management to standard smoking cessation treatment improved long term abstinence rates in adults with both current and past depression.(55) However, there are no systematic evaluations of smoking cessatio…”
Heffner, J. L., Mull, K. E., McClure, J. B., & Bricker, J. B. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2017.1387569 · Cited by 16
Fredman Stein, K., Sawyer, K., Daryan, S., Allen, J., & Taylor, G. (2023) · Health Expectations · doi:10.1111/hex.13684 · Cited by 11
“Past studies have shown that integrated interventions can be effective but have not explored how and why they work.(10) Our qualitative approach shed light on how participants made sense of what helped them reduce their smoking, situating these perceived mechanisms within the context of the participants' lives.”
BackgroundResultEtter, J., Cruz, G. V., & Khazaal, Y. (2023) · BMC Public Health · doi:10.1186/s12889-023-15859-6 · Cited by 16
“This may argue for adding psychosocial mood management components to smoking cessation apps to meet the needs of depressed people [28].”
BackgroundPredictors of 10‐year smoking abstinence in smokers abstinent for 1 year after treatment
Gutiérrez, F. J. Á., Galván, M. F., Bernal, A. R., Gallardo, J. F. M., Romero, B., Díaz, A. S., & Falcón, A. R. (2015) · Addiction · doi:10.1111/add.13220 · Cited by 15
“A recent Cochrane review [18] evaluating the effectiveness of smoking cessation interventions with a specific mood component in patients with a history of depression found a significant effect when psychosocial mood management was included in treatment, compared with standard smoking cessation interventions.”
BackgroundDahne, J., Wahlquist, A. E., Kustanowitz, J., Natale, N., Fahey, M. C., Graboyes, E. M., Díaz, V. A., & Carpenter, M. J. (2023) · Journal of Medical Internet Research · doi:10.2196/49809 · Cited by 15
“Tailored cessation treatments that incorporate depression-specific psychosocial treatment components increase long-term quit rates by up to 50% among those with current depressive symptoms [14].”
Nadkarni, A., Gaikwad, L., Sequeira, M., Javeri, P., Benoy, D., Pacheco, M. G., Velleman, R. D. B., Murthy, P., & Naughton, F. (2024) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntae259 · Cited by 14
“72 Despite the robustness of our methods, several issues need to be considered when making judgements about the applicability of these findings to programmes at scale.”
Most recommended medical interventions reach P < 0.005 for their primary outcomes in meta-analyses
Koletsi, D., Solmi, M., Pandis, N., Fleming, P. S., Correll, C. U., & Ioannidis, J. P. A. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz241 · Cited by 14
Taylor, G., Aveyard, P., Bartlem, K., Shaw, A., Player, J., Metcalfe, C., Kessler, D., & Munafò, M. (2019) · Pilot and Feasibility Studies · doi:10.1186/s40814-018-0385-2 · Cited by 11
“van der Meer and colleagues conducted a Cochrane review of smoking cessation treatments for people with current and historical depression [21] and found that adding psychosocial mood management to usual smoking cessation treatment (e.”
BackgroundDepressive Symptoms Among Patients Receiving Varenicline and Bupropion for Smoking Cessation
Hong, A. S., Elrashidi, M. Y., Schroeder, D. R., & Ebbert, J. O. (2014) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2014.11.010 · Cited by 12
Patient‐centred tobacco management
Gould, G. S. (2013) · Drug and Alcohol Review · doi:10.1111/dar.12082 · Cited by 14
Clawson, A. H., Borrelli, B., McQuaid, E. L., & DUNSIGER, S. I. (2016) · Health Psychology · doi:10.1037/hea0000318 · Cited by 12
Sheffer, C. E., Stein, J. S., Petrucci, C. M., Mahoney, M. C., Johnson, S., Giesie, P., Carl, E. M., Krupski, L., Tegge, A. N., Reid, M. E., et al. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113907 · Cited by 13
“Tobacco treatment may also add a standardized cognitive-behavioral mood management module for CSs with CES-D scores ≥ 16 [55].”
BackgroundGrabowska, K., Ziemichód, W., & Biała, G. (2023) · Brain Sciences · doi:10.3390/brainsci13010121 · Cited by 12
“Such factors may include the use of antidepressants [98], as an addition to the routine pharmacological therapy, e.”
BackgroundFacets of the NEO-PI-R and smoking cessation
del Río, E. D., López-Durán, A., Rodríguez-Cano, R., Martínez, Ú., Martínez-Vispo, C., & Becoña, E. (2015) · Personality and Individual Differences · doi:10.1016/j.paid.2015.02.030 · Cited by 9
Jani, B., Cavanagh, J., Barry, S., Der, G., Sattar, N. A., & Mair, F. S. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-139 · Cited by 14
Hashimoto, R., Tomioka, H., Wada, T., & Yoshizumi, Y. (2020) · Respiratory Investigation · doi:10.1016/j.resinv.2020.03.007 · Cited by 12
Minian, N., Ahad, S., Ivanova, A., Veldhuizen, S., Zawertailo, L. A., Ravindran, A. V., de Oliveira, C., Baliunas, D. O., Mulder, C., Bolbocean, C., et al. (2021) · Implementation Science · doi:10.1186/s13012-021-01091-6 · Cited by 12
“In addition, given the evidence supporting the integration of mood interventions within smoking cessation programming [25], and results from our readiness survey, where only 31% of HCPs reported having the specific capacity to implement mood management treatment, we felt it was important to provide all FHTs with some…”
BackgroundMethodResultInfluentialStepankova, L., Kralikova, E., Zvolska, K., Kmetova, A., Blaha, M., Bortlicek, Z., Sticha, M., Anders, M., Schroeder, D. R., & Croghan, I. T. (2013) · Preventing Chronic Disease · doi:10.5888/pcd10.130051 · Cited by 11
Hu, L., Liu, C., Lu, T., Hu, T., Tsai, C.-F., Hu, Y., Shen, C.-C., Chang, Y.-S., Chen, M., Teng, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080064 · Cited by 11
Quitline Programs Tailored for Mental Health: Initial Outcomes and Feasibility
Morris, C. D., Lukowski, A. V., Vargas-Belcher, R. A., Ylioja, T. E., Nash, C. M., & Bailey, L. A. (2021) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2020.02.025 · Cited by 12
Factors Associated With Mental Suffering in the Brazilian Population: A Multilevel Analysis
Bezerra, H. D. S., Alves, R. M., de Souza, T. A., Medeiros, A. D. A., & Barbosa, I. R. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.625191 · Cited by 11
Rosa, G. R. M. L., Giovane, C. D., Minozzi, S., Kowalski, J., Chapple, I., Amaliya, A., Farsalinos, K. E., & Polosa, R. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.105910 · Cited by 10
Tobacco Use Treatment in Primary Care Patients with Psychiatric Illness
Cerimele, J. M., Halperin, A. C., & Saxon, A. J. (2014) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2014.03.130252 · Cited by 8
Minian, N., Noormohamed, A., Baliunas, D. O., Zawertailo, L. A., Mulder, C., Ravindran, A. V., de Oliveira, C., & Selby, P. L. (2018) · JMIR Research Protocols · doi:10.2196/resprot.9715 · Cited by 10
Riley, E. D., Delucchi, K., Rubin, S., Weiser, S. D., Vijayaraghavan, M., Lynch, K. L., & Tsoh, J. Y. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.107125 · Cited by 11
Interventions for smoking cessation: An overview of Cochrane reviews
Lu, C.-L., Li, J.-X., Wang, Q., Wang, R., Pan, X.-R., Chen, X.-Y., Wang, C.-J., Chen, R., Yang, S.-H., Zhao, Z., et al. (2024) · Tobacco Induced Diseases · doi:10.18332/tid/195302 · Cited by 12
Kahler, C. W., Surace, A., Gordon, R. E. F., Cioe, P. A., Spillane, N. S., Parks, A. C., Bock, B. C., & Brown, R. A. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.06.013 · Cited by 8
“1% for those with past depression [14].”
Nieva, G., Comín, M., Valero, S., & Bruguera, E. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.04.003 · Cited by 8
Miedlich, S. U., & Lamberti, J. S. (2025) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15301 · Cited by 9
Two-Year Therapeutic Effectiveness of Varenicline for Smoking Cessation in a Real World Setting
Pascual, F. P., Ferrándiz, J. F., Sanchez, M. C. G., Lorenzo, F. P., & Estrella, C. B. (2016) · Substance Use & Misuse · doi:10.3109/10826084.2015.1018547 · Cited by 7
Zorick, T. S., Mandelkern, M. A., & Brody, A. L. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09012 · Cited by 7
A multiple health behaviour change intervention to prevent depression: A randomized controlled trial
Gómez‐Gómez, I., Motrico, E., Moreno-Peral, P., Casajuana‐Closas, M., López‐Jiménez, T., Zabaleta‐del‐Olmo, E., Clavería, A., Llobera, J., Martí‐Lluch, R., Ramos, R., et al. (2023) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2023.02.004 · Cited by 7
Yap, S. Y., Lunn, S., Pang, E., Croft, C., & Stern, M. (2015) · Chronic Respiratory Disease · doi:10.1177/1479972315586198 · Cited by 7
“Smokers with current or past depression are often more nicotine dependent, more likely to experience negative mood changes following nicotine withdrawal and more likely to relapse than the general population.(17) A meta-analytic review of smokers with COPD and current/past depression showed that additional psychosocia…”
BackgroundInfluentialCo-designing Behavior Change Resources With Treatment-Seeking Smokers: Engagement Events' Findings
Minian, N., Lingam, M., deRuiter, W. K., Dragonetti, R., & Selby, P. L. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.555449 · Cited by 5
“There is substantial evidence showing that when health care providers address health behaviors with their patients they can have a significant effect on their patient’s efforts to achieve smoking cessation (14, 15), reduce harmful alcohol consumption (16), increase exercise (17), as well as attain positive changes in…”
BackgroundMarti, C. N., Arora, S., & Loukas, A. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107809 · Cited by 6
Tabagisme et comorbidités psychiatriques
Dervaux, A., & Laqueille, X. (2016) · La Presse Médicale · doi:10.1016/j.lpm.2016.03.011 · Cited by 6
Adkins-Hempel, M., Japuntich, S. J., Chrastek, M., DUNSIGER, S. I., Breault, C., Ayenew, W., Everson‐Rose, S. A., Nijjar, P. S., Bock, B. C., Wu, W., et al. (2023) · Addiction Science & Clinical Practice · doi:10.1186/s13722-023-00388-9 · Cited by 6
“Based on existing data at the time of study design [36, 38, 86], we expect 7-day point prevalence rates to differ by 8% (29% in control, 37% in BAT-CS) at 12 months, representing an odds ratio of 1.”
MethodTobacco use disorder and other mental disorders: The neglected dual disorder
Parro-Torres, C., Casas, M., Martı́nez-Raga, J., Ogué, M. C. P., Martínez, P. A. S., & Szerman, N. (2024) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.sjpmh.2024.04.002 · Cited by 5
Metadata
- Authors
- van der Meer, R. M., Willemsen, M. C., Smit, F., & Cuijpers, P.
- Affiliations
- STIVORO, Dutch Expert Centre on Tobacco Control; The Hague Netherlands
- Maastricht University (NL)
- Trimbos Institute (NL)
- Vrije Universiteit Amsterdam (NL)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2013-08-21
- Volume
- 2013
- Issue
- 8
- Pages
- CD006102-CD006102
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W1698788306
- Cited by
- 159
- References
- 199
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 18 · 2015: 19 · 2014: 12 · 2013: 6
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Multilingual Matters (Channel View Publications) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- smoking cessation, depression, mood management, nicotine dependence, nicotine withdrawal, relapse, bupropion, nicotine replacement therapy, antidepressants, psychosocial interventions, smoking abstinence, relapse prevention, smoking cessation pharmacotherapy, behavioral support, tobacco dependence treatment
- MeSH terms
- Adult, Major Depressive Disorder, Humans, Smoking, Randomized Controlled Trials as Topic, Smoking Cessation, Bupropion, Treatment Outcome, Antidepressive Agents, Second-Generation, Tobacco Use Cessation Devices
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