Coenzyme Q10 for heart failure
Abstract
Background Coenzyme Q10, or ubiquinone, is a non-prescription nutritional supplement. It is a fat-soluble molecule that acts as an electron carrier in mitochondria and as a coenzyme for mitochondrial enzymes. Coenzyme Q10 deficiency may be associated with a multitude of diseases including heart failure. The severity of heart failure correlates with the severity of coenzyme Q10 deficiency. Emerging data suggest that the harmful effects of reactive oxygen species are increased in patients with heart failure and coenzyme Q10 may help to reduce these toxic effects because of its antioxidant activity. Coenzyme Q10 may also have a role in stabilising myocardial calcium-dependent ion channels and preventing the consumption of metabolites essential for adenosine-5'-triphosphate (ATP) synthesis. Coenzyme Q10, although not a primary recommended treatment, could be beneficial to patients with heart failure. Several randomised controlled trials have compared coenzyme Q10 to other therapeutic modalities, but no systematic review of existing randomised trials has been conducted. Objectives To review the safety and efficacy of coenzyme Q10 in heart failure. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2012, Issue 12); MEDLINE OVID (1950 to January Week 3 2013) and EMBASE OVID (1980 to 2013 Week 03) on 24 January 2013; Web of Science with Conference Proceedings (1970 to January 2013) and CINAHL Plus (1981 to January 2013) on 25 January 2013; and AM…
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Numerous studies have shown that intake of exogenous CoQ10 could help prevent progression of illness such as heart failure, metabolic syndrome, NAFLD, diabetes mellitus, and several neurodegenerative diseases.
“Numerous studies have shown that the intake of exogenous CoQ10 could help to prevent the progression of illness, such as heart failure, metabolic syndrome, NAFLD, diabetes mellitus, and several neurodegenerative diseases177,181–186.”
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- Authors
- Madmani, M. E., Yusuf Solaiman, A., Tamr Agha, K., Madmani, Y., Shahrour, Y., Essali, A., & Kadro, W.
- Affiliations
- MetroHealth Medical Center (US)
- Wayne State University; Neurology Department; 4640 cass ave Apt 202 Detroit MI USA 48201
- Damascus University-Medical College; Faculty of Medicine; Damascus Syrian Arab Republic
- Heart Group; London UK
- Damascus Syrian Arab Republic
- Modern Psychiatry Hospital; Psychiatry Centre; 27 Al Zahrawi Street Rawda Damascus Syrian Arab Republic
- The Golden Cardiovascular Centre; P.O. Box 6891 Damascus Syrian Arab Republic
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2014-06-02
- Issue
- 6
- Pages
- CD008684-CD008684
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W1596482823
- Cited by
- 94
- References
- 4
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 4 · 2016: 10 · 2015: 8 · 2014: 6
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Update notices
- new_version (2021-02-03)
- Open access
- closed
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- coenzyme Q10, heart failure, dietary supplements, antioxidant activity, reactive oxygen species, mitochondrial function, ATP production, treatment efficacy and safety, randomized controlled trials, risk of bias, quality of evidence, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction
- MeSH terms
- Ataxia, Heart Failure, Humans, Stroke Volume, Ubiquinone, Vitamins, Randomized Controlled Trials as Topic, Muscle Weakness, Mitochondrial Diseases
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