Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
Open accessAbstract
Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent.
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A lack of CoQ10 has been related to several conditions, including aging and neurological disorders.
“A lack of CoQ10 has been related to several conditions, including aging and neurological disorders [83,84,85,86,87,88,89] (Table 1).”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [87]
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- [45]Mantle D. Milford D. Hargreaves I.P. Chronic kidney disease and CoQ10 supplementation: An overview J. Kidney Care 2018 in press
- [74]Judy W. Ubiquinone and ubiquinol Proceedings of the Eighth Conference of the International CoQ10 Association Bologna, Italy 8–11 October 2015
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Self-citationThe Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Mantle, D., & Hargreaves, I.
- Affiliations
- Pharma Nord (United Kingdom) (GB)
- Liverpool John Moores University (GB)
- Corresponding author
- Mantle, David
- ORCID
- Hargreaves, Iain
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2019-02-16
- Volume
- 8
- Issue
- 2
- Pages
- 44
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC6406788
- OpenAlex
- W2914031145
- Cited by
- 63
- References
- 72
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 13 · 2020: 11 · 2019: 6
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- coenzyme Q10, longevity, degenerative diseases, cardiovascular disease, type 2 diabetes, chronic kidney disease, non-alcoholic fatty liver disease, selenium supplementation, mortality, glycemic control, antioxidants, anti-inflammatory agents, cellular energy metabolism
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