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Cited by 188Smoking Behavior and CessationPrenatal Substance Exposure EffectsPregnancy and Medication Impact

Pharmacological interventions for promoting smoking cessation during pregnancy

Open access
Claire, Ravinder, Chamberlain, Catherine, Davey, Mary-Ann, Cooper, Sue E, Berlin, Ivan, Leonardi-Bee, Jo, Coleman, Tim·2020·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd010078.pub3
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Abstract

Pharmacological interventions for promoting smoking

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Crossref · 10.1002/14651858.cd010078.pub3

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  • A 2017 Cochrane review included the most comprehensive evidence synthesis of tobacco cessation behavioral support interventions for pregnant women and was used as the basis for the findings presented here.

    “A 2017 Cochrane review included the most comprehensive evidence synthesis of tobacco cessation behavioral support interventions for pregnant women and was used as the basis for the findings presented here.[111](#R111)”

    From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [111]

    The cited paper is a 2020 review of pharmacological interventions, not the 2017 review of behavioural-support interventions described in the claim. In “Smoking cessation in pregnancy” (page unavailable), it directs readers to an associated review, Chamberlain 2017, for evidence on non-pharmacological interventions; it does not describe itself as the behavioural synthesis used for the citing document’s findings. (LLM, conf=0.90)

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  • Of the 102 included trials, 19 study groups reported rates of preterm births (less than 37 weeks' gestation), 26 study groups reported mean birthweight, and 17 groups reported rates of low-birthweight babies (less than 2500 g).

    “Of the 102 included trials, 19 study groups reported rates of preterm births (less than 37 weeks’ gestation), 26 study groups reported mean birthweight, and 17 groups reported rates of low-birthweight babies (less than 2500 g).[111](#R111)”

    From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [111]

    The Results of the search section says the review included 11 trials, not 102. The Outcomes section reports eight studies with mean birthweight data, seven with low-birthweight data, and six reporting preterm birth before 37 weeks—not the claimed 26, 17, and 19 study groups. The birthweight and preterm-birth thresholds in the claim do match the review. (LLM, conf=0.94)

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  • In an examination of counseling interventions compared with usual care, the average RR was 1.59 (95% CI, 1.26 to 2.01; 11 trials) at 0 to 5 months postpartum, 1.33 (95% CI, 1.00 to 1.77; 6 trials) at 6 to 11 months postpartum, and 2.20 (95% CI, 1.23 to 3.96; 2 trials) at 12 to 17 months.

    “For instance, in an examination of counseling interventions compared with usual care, the average RR was 1.59 (95% CI, 1.26 to 2.01; 11 trials) at 0 to 5 months postpartum, 1.33 (95% CI, 1.00 to 1.77; 6 trials) at 6 to 11 months postpartum, and 2.20 (95% CI, 1.23 to 3.96; 2 trials) at 12 to 17 months.[111](#R111)”

    From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [111]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 1 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

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  • Of the 19 trials reporting the effects of a behavioral intervention on preterm birth (less than 37 weeks), results were mixed, although the majority reported a reduced risk of preterm birth among women within the behavioral interventions versus control groups.

    “Of the 19 trials reporting the effects of a behavioral intervention on preterm birth (less than 37 weeks), results were mixed, although the majority reported a reduced risk of preterm birth among women within the behavioral interventions versus control groups.[111](#R111)”

    From Interventions for Tobacco Cessation in Adults, Including Pregnant Persons (2021) · cites this paper as [111]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 1 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

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  • Two reviewers independently applied GRADE criteria for each meta-analysed outcome, with disagreements resolved by consensus.

    “Two reviewers independently applied criteria for each meta-analysed outcome; disagreements were resolved by consensus [13].”

    From Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta-analysis. (2021) · cites this paper as [13]

    The 'Assessment of the certainty of the evidence using the GRADE approach' section says the authors applied GRADE to specified outcomes, but does not say two reviewers did so independently or that they assessed every meta-analysed outcome. The 'Assessment of risk of bias in included studies' section describes independent assessments and disagreements resolved with a third author, but those procedures concern study-level risk of bias, not GRADE assessments. (LLM, conf=0.87)

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References 129 · Cited by 188

Research works printed but not linked: 39

  1. Aveyard R, West R. Managing smoking cessation. BMJ 2007;335:37-41.
  2. Barbeau AM, Burda J, Siegel M. Perceived efficacy of e-cigarettes versus nicotine replacement therapy among successful e- cigarette users: a qualitative approach. Addiction Science & Clinical Practice 2013;8(1):5.
  3. Baric L, MacArthur C. Health norms in pregnancy. British Journal of Preventive and Social Medicine 1977;31(1):30-8.
  4. Belbasis L, Savvidou MD, Kanu C, Evangelou E, Tzoulaki I. Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses. BMC Medicine 2016;14(1):147.
  5. Blalock JA, Fouladi RT, Wetter DW, Cinciripini PM. Depression in pregnant women seeking smoking cessation treatment. Addictive Behaviors 2005;30(6):1195-208.
  6. Blalock JA, Nayak N, Wetter DW, Schreindorfer L, Minnix JA, Canul J, et al. The relationship of childhood trauma to nicotine dependence in pregnant smokers. Psychology of Addictive Behaviors 2011;25(4):652.
  7. Bruin JE, Gerstein HC, Holloway AC. Long-term consequences of fetal and neonatal nicotine exposure: a critical review. Toxicological Sciences 2010;116(2):364-74.
  8. Bush J, White M, Kai J, Rankin J, Bhopal R. Understanding influences on smoking in Bangladeshi and Pakistani adults: community based, qualitative study. BMJ 2003;326:962.
  9. Hajek P, Phillips-Waller A, Przulj D, Pesola F, Myers Smith K, Bisal N, et al. A randomized trial of e-cigarettes versus nicotine- replacement therapy. New England Journal of Medicine 2019;380(7):629-37.
  10. Hammoud AO, Bujold E, Sorokin Y, Schild C, Krapp M, Baumann P. Smoking in pregnancy revisited: findings from a large population-based study. American Journal of Obstetrics & Gynecology 2005;192(6):1856-63.
  11. Hartmann-Boyce J, McRobbie H, Bullen C, Begh R, Stead LF, Hajek P. Electronic cigarettes for smoking cessation. Cochrane Database of Systematic Reviews 2016, Issue 9. [DOI: 10.1002/14651858.CD010216.pub3] · DOI
  12. Herrmann M, King K, Weitzman M. Prenatal tobacco smoke and postnatal secondhand smoke exposure and child neurodevelopment. Current Opinion in Pediatrics 2008;20(2):184-90.
  13. Hickson C, Lewis S, Campbell KA, Cooper S, Berlin I, Claire R, et al. Comparison of nicotine exposure during pregnancy when smoking and abstinent with nicotine replacement therapy: systematic review and meta-analysis. Addiction 2019;114(3):406-24.
  14. Hunt J. Trying to Make a Difference: Improving Pregnancy Outcomes, Care and Services for Australian Indigenous Women [thesis]. Victoria: LaTrobe University, 2003.
  15. Kaplan SD, Lanier AP, Merritt RK, Siegel PZ. Prevalence of tobacco use among Alaska natives: a review. Preventive Medicine 1997;26(4):460-5.
  16. Kramer MS. Determinants of low birth weight: methodological assessment and meta-analysis. Bulletin of the World Health Organization 1987;65(5):663-737.
  17. Kumar R, Gould GS. Tobacco harm reduction for women who cannot stop smoking during pregnancy -a viable option?. JAMA Pediatrics 2019;173(7):615-6.
  18. Lanting CI, van Wouwe JP, van den Burg I, Segaar D, van der Pal-de Bruin KM. Smoking during pregnancy: trends between 2001 and 2010 [Roken tijdens de zwangerschap: trends in de periode 2001-2010]. Nederlands Tijdschri Voor Geneeskunde 2012;156(46):A5092.
  19. Maritz GS. Are nicotine replacement therapy, varenicline or bupropion options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring. Therapeutic Advances in Respiratory Disease 2009;3(4):193-210.
  20. Marufu TC, Ahankari A, Coleman T, Lewis S. Maternal smoking and the risk of still birth: systematic review and meta-analysis. BMC Public Health 2015;15(1):239.
  21. McBride CM, Emmons KM, Lipkus IM. Understanding the potential of teachable moments: the case of smoking cessation. Health Education Research 2003;18(2):156-70.
  22. McNeill A, Brose LS, Calder R, Bauld L, Robson D. Evidence review of e-cigarettes and heated tobacco products 2018. A report commissioned by Public Health England. London: Public Health England; 2018 February.
  23. Notley C, Gentry S, Livingstone-Banks J, Bauld L, Perera R, Hartmann-Boyce J. Incentives for smoking cessation. Cochrane Database of Systematic Reviews 2019, Issue 7. [DOI: 10.1002/14651858.CD004307.pub6] · DOI · Paper page
  24. Oncken 2009b Oncken CA, Kranzler HR. What do we know about the role of pharmacotherapy for smoking cessation before or during pregnancy?. Nicotine & Tobacco Research 2009;11(11):1265-73.
  25. Oncken CA, Dietz PA, Tong VT, Belizan JM, Tolosa JE, Berghella V, et al. Prenatal tobacco prevention and cessation interventions for women in low-and middle-income countries. Acta Obstetricia et Gynecologica Scandinavica 2010;89(4):442-53.
  26. Oncken C, Ricci KA, Kuo CL, Dornelas E, Kranzler HR, Sankey HZ. Correlates of electronic cigarettes use before and during pregnancy. Nicotine & Tobacco Research 2017;19(5):585-90.
  27. Pickett KE, Wilkinson RG, Wakschlag LS. The psychosocial context of pregnancy smoking and quitting in the Millennium Cohort Study. Journal of Epidemiology and Community Health 2009;63(6):474-80.
  28. Polosa R, Caponnetto P, Morjaria JB, Papale G, Campagna D, Russo C. Effect of an electronic nicotine delivery device (e- Cigarette) on smoking reduction and cessation: a prospective 6- month pilot study. BMC Public Health 2011;11(1):786.
  29. Potter A, Lumley J, Watson L. The 'new' risk factors for SIDS: is there an association with ethnic and place of birth differences in incidence in Victoria?. Early Human Development 1996;45:119-31. References to other published versions of this review Coleman 2012
  30. Coleman T, Chamberlain C, Davey MA, Cooper SE, Leonardi- Bee J. Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database of Systematic Reviews 2012, Issue 9. [DOI: 10.1002/14651858.CD010078] · DOI
  31. Coleman T, Chamberlain C, Davey MA, Cooper SE, Leonardi-Bee J. Pharmacological interventions for promoting smoking cessation during pregnancy. Cochrane Database of Systematic Reviews 2015, Issue 12. [DOI: 10.1002/14651858.CD010078.pub2] · DOI · Paper page
  32. Lumley 1995a Lumley J. Advice as a strategy for reducing smoking in pregnancy. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM] The Cochrane Collaboration; Issue 2, Oxford: Update So ware; 1995.
  33. Lumley 1995b Lumley J. Behavioural strategies for reducing smoking in pregnancy. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM] The Cochrane Collaboration; Issue 2, Oxford: Update So ware; 1995.
  34. Lumley 1995c Lumley J. Counselling for reducing smoking in pregnancy. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM] The Cochrane Collaboration; Issue 2, Oxford: Update So ware; 1995.
  35. Lumley 1995d Lumley J. Feedback as a strategy for reducing smoking in pregnancy. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM] The Cochrane Collaboration; Issue 2, Oxford: Update So ware; 1995.
  36. Lumley 1995e Lumley J. Strategies for reducing smoking in pregnancy. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP, Crowther C (eds.) Pregnancy and Childbirth Module. In: The Cochrane Pregnancy and Childbirth Database [database on disk and CDROM] The Cochrane Collaboration; Issue 2, Oxford: Update So ware; 1995.
  37. Lumley J, Oliver S, Waters E. Interventions for promoting smoking cessation during pregnancy. Cochrane Database of Systematic Reviews 1999, Issue 4. [DOI: 10.1002/14651858.CD001055] · DOI
  38. Lumley J, Oliver S, Chamberlain C, Oakley L. Interventions for promoting smoking cessation in pregnancy. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD001055.pub2] · DOI
  39. Lumley J, Chamberlain C, Dowswell T, Oliver S, Oakley L, Watson L. Interventions for promoting smoking cessation during pregnancy. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD001055.pub3] · DOI · Paper page

Authors
Claire, R., Chamberlain, C., Davey, M.-A., Cooper, S. E., Berlin, I., Leonardi-Bee, J., & Coleman, T.
Affiliations
  • University of Nottingham (GB)
  • La Trobe University (AU)
  • Monash University (AU)
  • Sorbonne Université (FR)
  • University of Nottingham; Centre for Evidence Based Healthcare, Division of Epidemiology and Public Health, Clinical Sciences Building Phase 2; Nottingham City Hospital Hucknall Road Nottingham UK NG5 1PB
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2020-03-04
Volume
2020
Issue
3
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd010078.pub3
OpenAlex
W4235353107
Cited by
188
References
129
Citations by year
2026: 13 · 2025: 20 · 2024: 33 · 2023: 28 · 2022: 39 · 2021: 29 · 2020: 19 · 2019: 3 · 2018: 1 · 2016: 2 · 2013: 1
FWCI
3.67
Type
journal article
Language
en
Open access
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • Repository@Nottingham (University of Nottingham) (publishedVersion, other-oa)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Funders
  • U.S. Department of Health and Human Services
  • McMaster University
  • National Institute for Health and Care Research (NF-SI-0617-10091, RP-PG-0615-20003)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
smoking cessation, pregnancy, pharmacological interventions, nicotine replacement therapy, smoking during pregnancy

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