The DOI matches its Crossref record; 78 of the 80 references it cites were found in a registry or an index.
Probiotics for vulvovaginal candidiasis in non-pregnant women
Open accessAbstract
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women. SEARCH METHODS: We searched the following databases to October 2017: Sexually Transmitted Infections Cochrane Review Group's Specialized Register, CENTRAL, MEDLINE, Embase and eight other databases. We searched in following international resources: World Health Organization International Clinical Trials Registry Platform, ClinicalTrials.gov, Web of Science and OpenGrey. We checked specialty journals, reference lists of published articles and conference proceedings. We collected information from pharmaceutical companies and experts in the field. SELECTION CRITERIA: Randomized controlled trials (RCT) using probiotics, alone or as adjuvants to conventional antifungal drugs, to treat VVC in non-pregnant women. Trials recruiting women with recurrent VVC, coinfection with other vulvovaginal infections, diabetes mellitus, immunosuppressive disorders or taking immunosuppressant medication were ineligible for inclusion. Probiotics were included if they were made from single or multiple species and in any preparation type/dosage/route of administration. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trials for eligibility and quality and extracted data. We resolved any disagreements through consensus. The quality of the evidence was assessed using the GRADE approach. MAIN RESULTS: Ten RCTs (1656 participants) met our inclusion criteria, and pharmaceutical industry funded none of these trials. All trials used probiotics as adjuvant therapy to antifungal drugs. Probiotics increased the rate of short-term clinical cure (risk ratio (RR) 1.14, 95% confidence interval (CI) 1.05 to 1.24, 695 participants, 5 studies, low quality evidence) and mycological cure (RR 1.06, 95% CI 1.02 to 1.10, 969 participants, 7 studies, low quality evidence) and decreased relapse rate at one month (RR 0.34, 95% CI 0.17 to 0.68, 388 participants, 3 studies, very low quality evidence). However, this effect did not translate into a higher frequency of long-term clinical cure (one month after treatment: RR 1.07, 95% CI 0.86 to 1.33, 172 participants, 1 study, very low quality evidence; three months after treatment: RR 1.30, 95% CI 1.00 to 1.70, 172 participants, one study, very low quality evidence) or mycological cure (one month after treatment: RR 1.26, 95% CI 0.93 to 1.71, 627 participants, 3 studies, very low quality evidence; three months after treatment: RR 1.16, 95% CI 1.00 to 1.35, 172 participants, one study, very low quality evidence). Probiotics use did not increase the frequency of serious (RR 0.80, 95% CI 0.22 to 2.94; 440 participants, 2 studies, low quality evidence). We found no eligible RCTs for outcomes as time to first relapse, need for additional treatment at the end of therapy, patient satisfaction and cost effectiveness. AUTHORS' CONCLUSIONS: Low and very low quality evidence shows that, compared with conventional treatment, the use of probiotics as an adjuvant therapy could increases the rate of short-term clinical and mycological cure and decrease the relapse rate at one month but this did not translate into a higher frequency of long-term clinical or mycological cure. Probiotics use does not seem to increase the frequency of serious or non-serious adverse events. There is a need for well-designed RCTs with standardized methodologies, longer follow-up and larger sample size.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, probiotics used alone have no effect on long-term improvement in cure rates [77].”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [77]
In the citing paper
“The results of a systematic review of the use of probiotics in VVC patients showed that the addition of probiotics can enhance the effectiveness and effect of conventional antifungal drugs in terms of short-term improvement in cure rates.”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Parmar, M. K. B., Torri, V., & Stewart, L. (1998) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19981230)17:24 · Cited by 4,519
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191
Sexually Transmitted Diseases Treatment Guidelines, 2006
SKOLNIK, N. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-313-4_17 · Cited by 3,115
Sexually transmitted diseases treatment guidelines
Burstein, G. R., & Workowski, K. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200308000-00006 · Cited by 2,077
Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines
Workowski, K., & Berman, S. M. (2007) · Clinical Infectious Diseases · doi:10.1086/511430 · Cited by 1,977
Sobel, J. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60917-9 · Cited by 1,270
Sexually Transmitted Diseases Treatment Guidelines 2002
(2002) · PsycEXTRA Dataset · doi:10.1037/e548482006-001 · Cited by 1,238
Potential Uses of Probiotics in Clinical Practice
Reid, G., Jaß, J., Sebulsky, M. T., & McCormick, J. K. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.658-672.2003 · Cited by 918
Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences
Sanglard, D., & Odds, F. C. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00181-0 · Cited by 784
Vulvovaginal candidiasis: Epidemiologic, diagnostic, and therapeutic considerations
Sobel, J. D., Faro, S., Force, R. W., Foxman, B., Ledger, W. J., Nyirjesy, P., Reed, B. D., & Summers, P. R. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)80001-x · Cited by 694
Research works printed but not linked: 18
- Han, 2006, Clinical observation of Ding Jun Sheng and clotrimazole vaginal tablet in the treatment of vulvovaginal candidiasis, Anhui Medical Journal, 27, 528
- Lin, 2006, Clinical application of Lactasin capsules in vaginitis, Journal of Practical Medicine, 22, 1927
- Ma, 2007, Miconazole plus Lactasin capsules to treat vulvovaginal candidiasis (54 cases), Herald of Medicine, 26, 1041
- Zhang, 2005, Preventive effect of probiotic Lactobacillus on vulvovaginal candidiasis, Maternal and Child Health Care of China, 20, 2239
- Fu, 2009, Effect observation of two treatment methods for vulvovaginal candidiasis, Contemporary Medicine, 15, 95
- Fu, 2012, Effect observation of Ding Jun Sheng plus clotrimazole to treat Candida vaginitis, Journal of Henan Medical College for Staff and Workers, 24, 760
- Li, 2007, Clinical observation of Daktarin vaginal suppository and (or) Ding Jun Sheng to treat vulvovaginal candidiasis, Journal of Gannan Medical College, 27, 606
- Liu, 2008, Clinical observation of Lactobacillus preparation for vulvovaginal candidiasis, Maternal and Child Health Care of China, 23, 4644
- Shi, 2012, The clinical effect of live preparation of Lactobacillus in treatment of vulvovaginal candidiasis and the recurrence rate, Chinese Journal of Microecology, 24, 278
- Wang, 2010, The treatment and prevention of recurrence of vulvovaginal candidiasis, Strait Journal of Preventive Medicine, 16, 89
- Wu, 2013, Lactasin capsules for postpartum vaginitis, Chinese Journal of New Drugs, 22, 819
- Yang, 2005, Ding Jun Sheng used in the inhibition of vaginal yeast infection recurrence, Hainan Medical Journal, 16, 102
- Zhang, 2006, Effect observation of Ding Jun Sheng to treat colpitis mycotica, Modern Journal of Integrated Traditional Chinese and Western Medicine, 15, 144
- Zhang, 2007, Clinical observation of Ding Jun Sheng plus nystatin to treat vulvovaginal candidiasis, Progress in Obstetrics and Gynecology, 16, 555
- Bieber, 2006, Clinical Gynecology
- Martinez, 2009, Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, Letters in Applied Microbiology, 48, 269, 10.1111/j.1472-765X.2008.02477.x · DOI
- The Nordic Cochrane Centre, The Cochrane Collaboration Review Manager (RevMan) 2014
- Zhang, 2008, Safety and clinical use of microecological preparations, Adverse Drug Reactions Journal, 10, 340
Cited by
Sorted by citations
Role of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375
Factors affecting the composition of the gut microbiota, and its modulation
Hasan, N., & Yang, H. (2019) · PeerJ · doi:10.7717/peerj.7502 · Cited by 807
Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health
Chee, W. J. Y., Chew, S. Y., & Than, L. T. L. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01464-4 · Cited by 761
Koedooder, R., Singer, M., Schoenmakers, S., Savelkoul, P. H. M., Morré, S. A., de Jonge, J. D., Poort, L., Cuypers, W. J. S. S., Beckers, N. G. M., Broekmans, F. J. M., et al. (2019) · Human Reproduction · doi:10.1093/humrep/dez065 · Cited by 257
Guideline: Vulvovaginal Candidosis (AWMF 015/072, Level S2k)
Farr, A., Effendy, I., Frey Tirri, B., Hof, H., Mayser, P., Petricevic, L., Ruhnke, M., Schaller, M., Schaefer, A. P. A., Sustr, V., et al. (2021) · Mycoses · doi:10.1111/myc.13248 · Cited by 184
Barrientos‐Durán, A., Fuentes, A. P., de Salazar, A., Plaza‐Díaz, J., & García, F. (2020) · Nutrients · doi:10.3390/nu12020419 · Cited by 188
Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions
Han, Y., Liu, Z., & Chen, T. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.643422 · Cited by 144
Healthy Vaginal Microbiota and Influence of Probiotics Across the Female Life Span
Lehtoranta, L., Ala‐Jaakkola, R., Laitila, A., & Maukonen, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.819958 · Cited by 146
The female reproductive tract microbiotas, inflammation, and gynecological conditions
Gholiof, M., Luca, E. A.-D., & Wessels, J. M. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.963752 · Cited by 137
The Vaginal Microbiome: A Long Urogenital Colonization Throughout Woman Life
Auriemma, R. S., Scairati, R., Vecchio, G. D., Liccardi, A., Verde, N., Pirchio, R., Pivonello, R., Ercolini, D., & Colao, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.686167 · Cited by 114
Probiotics and vaginal microecology: fact or fancy?
Buggio, L., Somigliana, E., Borghi, A., & Vercellini, P. (2019) · BMC Women s Health · doi:10.1186/s12905-019-0723-4 · Cited by 101
Russo, R., Superti, F., Karadja, E., & De Seta, F. (2019) · Mycoses · doi:10.1111/myc.12883 · Cited by 94
Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods
Satora, M., Grunwald, A., Zaremba, B., Frankowska, K., Żak, K., Tarkowski, R., & Kułak, K. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165376 · Cited by 84
Donders, G., Sziller, I. O., Paavonen, J., Hay, P., de Seta, F., Bohbot, J. M., Kotarski, J., Vives, J. A., Szabo, B., Cepuliené, R., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.934353 · Cited by 82
Bacterial vaginosis: a primer for clinicians
Reiter, S., & Spadt, S. K. (2018) · Postgraduate Medicine · doi:10.1080/00325481.2019.1546534 · Cited by 70
Borghi, M., Pariano, M., Solito, V., Puccetti, M., Bellet, M. M., Stincardini, C., Renga, G., Vacca, C., Sellitto, F., Mosci, P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02364 · Cited by 63
Role of Vaginal Mucosa, Host Immunity and Microbiota in Vulvovaginal Candidiasis
Balakrishnan, S. N., Yamang, H., Lorenz, M. C., Chew, S. Y., & Than, L. T. L. (2022) · Pathogens · doi:10.3390/pathogens11060618 · Cited by 73
Progress in Probiotic Science: Prospects of Functional Probiotic‐Based Foods and Beverages
Manan, M. A. (2025) · International Journal of Food Science · doi:10.1155/ijfo/5567567 · Cited by 76
Brown, S. E., Schwartz, J. A. J., Robinson, C. K., O’Hanlon, D. E., Bradford, L. L., He, X., Mark, K., Bruno, V. M., Ravel, J., & Brotman, R. M. (2019) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000001066 · Cited by 61
dos Santos, C. I., França, Y. R., Campos, C. D. L., Bomfim, M. R. Q., de Melo, B. O., Holanda, R. A., dos Santos, V. L., Monteiro, S. G., Moffa, E. B., Monteiro, A. S., et al. (2019) · Pathogens · doi:10.3390/pathogens8030150 · Cited by 60
Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis
Neal, C. M., & Martens, M. G. (2022) · SAGE Open Medicine · doi:10.1177/20503121221115201 · Cited by 56
Genital Micro-Organisms in Pregnancy
Bagga, R., & Arora, P. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00225 · Cited by 57
Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli
Superti, F., & Seta, F. D. (2020) · Microorganisms · doi:10.3390/microorganisms8010130 · Cited by 52
Treatment for recurrent vulvovaginal candidiasis (thrush)
Cooke, G., Watson, C., Deckx, L., Pirotta, M., Smith, J., & van Driel, M. L. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009151.pub2 · Cited by 48
Artym, J., & Zimecki, M. (2021) · Biomedicines · doi:10.3390/biomedicines9121940 · Cited by 51
Treating vaginitis with probiotics in non‑pregnant females: A systematic review and meta‑analysis
Jeng, H., Yan, T., & Chen, J. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9090 · Cited by 46
Mizgier, M., Jarząbek‐Bielecka, G., Mruczyk, K., & Kędzia, W. (2020) · Ginekologia Polska · doi:10.5603/gp.2020.0070 · Cited by 41
Enggi, C. K., Sulistiawati, S., Stephanie, S., Tangdilintin, F., Achmad, A. A., Putri, R. A., Burhanuddin, H., Arjuna, A., Manggau, M. A., & Permana, A. D. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.05.165 · Cited by 38
Nesbitt, H., Burke, C., & Haghi, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.713703 · Cited by 36
Host-microbe interaction paradigms in acute and recurrent vulvovaginal candidiasis
MacAlpine, J., & Lionakis, M. S. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.08.018 · Cited by 41
Vulvovaginal candidiasis-an overview of current trends and the latest treatment strategies
Bhosale, V. B., Koparde, A. A., & Thorat, V. M. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107359 · Cited by 43
Lactobacillus rhamnosus AD3 as a promising alternative for probiotic products
Stivala, A., Carota, G., Fuochi, V., & Furneri, P. M. (2021) · Biomolecules · doi:10.3390/biom11010094 · Cited by 31
Li, T., Liu, Z., Li, K., & Bai, H. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000211 · Cited by 30
Mollazadeh-Narestan, Z., Yavarikia, P., Homayouni-Rad, A., Samadi Kafil, H., Mohammad-Alizadeh-Charandabi, S., Gholizadeh, P., & Mirghafourvand, M. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09997-3 · Cited by 29
The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections
Boahen, A., Than, L. T. L., Loke, Y.-L., & Chew, S. Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.787119 · Cited by 34
Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice
Huang, J. M., Shan, W., Li, F., Wang, Z., Cheng, J., Lu, F., Guo, E., Beejadhursing, R., Xiao, R., Liu, C., et al. (2021) · Aging · doi:10.18632/aging.202627 · Cited by 27
Selis, N. D. N., Oliveira, H. B. M., Leão, H. F., dos Anjos, Y. B., Sampaio, B. A., Correia, T. M. L., Almeida, C. F., Pena, L. S. C., Reis, M. M., Brito, T. L. S., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02264-5 · Cited by 23
Abavisani, M., Sahebi, S., Dadgar, F., Peikfalak, F., & Keikha, M. (2024) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2024.03.004 · Cited by 22
Effect of probiotics on vaginal Ureaplasma parvum in women suffering from unexplained infertility
Schenk, M., Grumet, L., Sternat, J., Reinschissler, N., & Weiss, G. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.06.004 · Cited by 21
Donders, G. G. G., Grincevičienė, Š., Ruban, K., & Bellen, G. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115024 · Cited by 21
Recurrent vulvovaginal candidiasis
Lines, A., Vardi-Flynn, I., & Searle, C. (2020) · BMJ · doi:10.1136/bmj.m1995 · Cited by 21
Donders, G., Bellen, G., Oerlemans, E., Claes, I., Ruban, K., Henkens, T., Kiekens, F., & Lebeer, S. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-03868-x · Cited by 20
Assessment and Treatment of Vaginitis
Mitchell, C. M. (2024) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005673 · Cited by 22
Chi in Igbo Religion and Thought: The God in Every Man
Chukwukere, I. (1983) · Cited by 20
Ultraviolet A/blue light-emitting diode therapy for vulvovaginal candidiasis: a case presentation
Leal, M. R. D., Pavie, M. C., Garcia, I. F. M., Menezes, M. P., Bastos, M. D. C., Leite, H. J. D., Noites, A., & Lordêlo, P. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02782-9 · Cited by 19
Candidiasis, Bacterial Vaginosis, Trichomoniasis and Other Vaginal Conditions Affecting the Vulva
Vieira‐Baptista, P., & Bornstein, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-61621-6_24 · Cited by 18
Probiotics in Dermatology: An Evidence-based Approach
Gowda, V., Sarkar, R., Verma, D., & Das, A. (2024) · Indian Dermatology Online Journal · doi:10.4103/idoj.idoj_614_23 · Cited by 19
Tumietto, F., Posteraro, B., & Sanguinetti, M. (2019) · Future Microbiology · doi:10.2217/fmb-2019-0189 · Cited by 16
Probiotics in the Management of Vulvovaginal Candidosis
Akinosoglou, K., Schinas, G., Polyzou, E., Tsiakalos, A., & Donders, G. G. G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175163 · Cited by 15
Dausset, C., Bornes, S., Miquel, S., Kondjoyan, N., Angénieux, M., Nakusi, L., Veisseire, P., Alaterre, E., Bermúdez‐Humarán, L. G., Langella, P., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74027-7 · Cited by 17
Risks for Recurrent Vulvovaginal Candidiasis Caused by Non-Albicans Candida Versus Candida Albicans
Tressler, A. B., Markwei, M. T., Fortin, C. N., Yao, M., Procop, G. W., Soper, D. E., & Goje, O. (2021) · Journal of Women s Health · doi:10.1089/jwh.2020.8811 · Cited by 14
ElFeky, D. S., Awad, A. R., ShamsEldeen, A. M., Mowafy, H. L., & Hosny, S. A. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1222503 · Cited by 15
Pedro, N. A., & Mira, N. P. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127628 · Cited by 14
Witteman, L., van Wietmarschen, H., & van der Werf, E. T. (2021) · Antibiotics · doi:10.3390/antibiotics10030250 · Cited by 15
Vahedpoor, Z., Abastabar, M., Sehat, M., Talebian, P., fini, T. F., Dastanpour, Z., Haghani, I., Chelongarian, R., & Nazeri, M. (2021) · Current Medical Mycology · doi:10.18502/cmm.7.3.7803 · Cited by 13
Bassi, A., Sharma, G., Deol, P. K., Madempudi, R. S., & Kaur, I. P. (2023) · Gels · doi:10.3390/gels9030244 · Cited by 17
Role of Complementary and Alternative Therapies in Infectious Disease
Baker, J. H., Qiu, J. J., & Grine, K. (2018) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2018.05.009 · Cited by 12
He, X., Tang, Q.-L., Zhan, F., Mao, Y., Ye, F., Weng, Z., Jiang, X., & Swidsinski, A. V. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15577 · Cited by 10
Zeng, X., An, R., Li, H., & Zhang, Y. (2023) · Medicine · doi:10.1097/md.0000000000032664 · Cited by 9
Premature rupture of membranes and changes in the vaginal microbiome – Probiotics
Gorczyca, K., Kozioł, M. M., Kimber-Trojnar, Ż., Kępa, J., Satora, M., Rekowska, A. K., & Leszczyńska‐Gorzelak, B. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100899 · Cited by 9
Review: Probiotics in dermatology
Sudhamani, B. (2019) · Journal of Skin and Sexually Transmitted Diseases · doi:10.25259/jsstd_18_2019 · Cited by 11
Diagnosis and treatment of vulvovaginal candidiasis: a practical approach
Cianci, A., Cicinelli, E., Colacurci, N., Leo, V. D., Perino, A., Pino, A., Bartolo, E., Randazzo, C. L., Esposito, G., Chiaffarino, F., et al. (2020) · Italian Journal of Gynaecology and Obstetrics · doi:10.36129/jog.32.04.05 · Cited by 9
Tian, Q., Jin, S., Zhang, G., Liu, Y., Liu, J., Tang, X., Li, Y., Liu, J., Liu, Y., & Wang, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1380187 · Cited by 8
Genovese, C., Cianci, A., Corsello, S., Ettore, G., Mattana, P., & Tempera, G. (2019) · Minerva Obstetrics and Gynecology · doi:10.23736/s0026-4784.19.04388-0 · Cited by 8
A Prerequisite for Health: Probiotics
Rossoni, R. D., Ribeiro, F. D. C., de Barros, P. P., Mylonakis, E. E., & Junqueira, J. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816664-2.00011-6 · Cited by 9
Liang, X., Li, Z., Tye, K. D., Chen, Y., Luo, H., & Xiao, X. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14434 · Cited by 13
Jawanda, I. K., Soni, T., Kumari, S., & Prabha, V. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04024-1 · Cited by 6
Blaganje, M., & Barbič, M. (2020) · Current Bladder Dysfunction Reports · doi:10.1007/s11884-020-00606-z · Cited by 7
Update on recurrent vulvovaginal candidiasis
Borland, A., Ovens, K., Offiah, I., Dua, A., & Freeman, R. (2021) · The Obstetrician & Gynaecologist · doi:10.1111/tog.12772 · Cited by 5
Bradfield Strydom, M., Walpola, R. L., Khan, S., Ware, R. S., & Tiralongo, E. (2021) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13376 · Cited by 5
The Hygienic Significance of Microbiota and Probiotics for Human Wellbeing
Todorov, S. D., Tagg, J. R., Algburi, A., Tiwari, S. K., Popov, I. V., Weeks, R. M., Mitrokhin, O. V., Kudryashov, I. A., Александрович, К. Д., & Chikindas, M. L. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10419-9 · Cited by 5
Paludo, R. M., & Marin, D. (2018) · Revista Destaques Acadêmicos · doi:10.22410/issn.2176-3070.v10i3a2018.1745 · Cited by 5
Leonova, M. V. (2020) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2020-13-148-154 · Cited by 4
Wittman, E., Yar, N., Seta, F. D., & Larsen, B. (2021) · Pathogens · doi:10.3390/pathogens10030289 · Cited by 4
Pane, M., & Chisari, E. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1428590 · Cited by 5
Danjuma, F. Y., Dashen, M. M., Ngene, A. C., & Egbere, O. J. (2025) · Advanced Gut & Microbiome Research · doi:10.1155/agm3/5476030 · Cited by 3
Liu, Y., Li, M., Yi, H., Song, D., Lou, Y., Fan, S., Yang, X., Lu, J., Hu, L., Zhou, P., et al. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100225 · Cited by 3
Lactobacilli and lactic acid in maintaining and restoring women’s health
Носенко, О. М., & Demidchik, R. Y. (2023) · Reproductive health of woman · doi:10.30841/2708-8731.8.2023.297795 · Cited by 3
Gut microbiome in dermatology – A narrative review
Pai, V. V., Sarath, A. P., & Kerkar, Z. (2025) · Indian Journal of Dermatology Venereology and Leprology · doi:10.25259/ijdvl_1094_2024 · Cited by 4
Vaginitis, Vulvovaginitis, and Vulvodynia
Szybala, M. P., & Szybala, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00224-7 · Cited by 3
Zhang, H., Li, C., Wu, H., Li, Z., Wu, D., Shao, J., Wang, T., & Wang, C. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106250 · Cited by 2
Vaginal Capsules: A Viable Alternative for the Delivery of Lactobacillus spp.
de Lima, L. S., Pereira, L. C., Almeida, R. M., & Nóbrega, Y. K. D. M. (2025) · Microorganisms · doi:10.3390/microorganisms13051056 · Cited by 2
Critical Overview of Probiotics Efficacy on Health and its Safety
Deka, B., Dash, B., Saud, B., Bhattacharjee, B., & Ikbal, A. M. A. (2021) · Pharmaceutical and Biosciences Journal · doi:10.20510/pbj/9/i2/1275 · Cited by 3
Role of probiotics in the management of fungal infections
Chaudhari, A., Bharti, A. H., & Dwivedi, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00015-5 · Cited by 2
Marquez, S. M. T., & Reyes, L. D. (2022) · Philippine Journal of Obstetrics and Gynecology · doi:10.4103/pjog.pjog_24_22 · Cited by 2
Foessleitner, P. (2024) · Die Gynäkologie · doi:10.1007/s00129-024-05317-8 · Cited by 2
Role of probiotics in prevention and treatment of Candida vaginitis and Bacterial vaginosis
Adesulu-Dahunsi, A. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00007-6 · Cited by 2
Pisarska-Krawczyk, M., Jarząbek‐Bielecka, G., Mizgier, M., Plagens-Rotman, K., Friebe, Z., & Kędzia, W. (2021) · Pielegniarstwo XXI wieku / Nursing in the 21st Century · doi:10.2478/pielxxiw-2021-0015 · Cited by 2
Intérêt de Saccharomyces boulardii CNCM I-745 dans la prise en charge des infections vulvo-vaginales
Bohbot, J.-M., & Zhioua, F. (2021) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2021.04.008 · Cited by 2
Sistemas de liberação para anfotericina B e miltefosina no tratamento das candidíases.
de Bastiani, F. W. M. D. S. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-28012019-153532 · Cited by 2
Kaur, K. K., Allahbadia, G., & Singh, M. (2019) · ACTA SCIENTIFIC MICROBIOLOGY · doi:10.31080/asmi.2019.02.0421 · Cited by 1
Multistrain Probiotics and Benefits to Consumer’s Health
Ouwehand, A. C., Invernici, M. D. M., Messora, M. R., & Furlaneto, F. A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819662-5.00002-1 · Cited by 1
Pérez-Llantada, J. G., Masero-Casasola, A. R., Lázaro-Carrasco, J., Carballo, M. J., Ridocci, F., Sosa, M., González, M., Azumendi, P., Palma, M. J. D. C., & Nieto, C. (2021) · International Journal of Microbiology and Biotechnology · doi:10.11648/j.ijmb.20210604.11 · Cited by 1
Prebiotics and Probiotics in Vulvovaginal Infections
Shah, P., Tandon, S., Purandare, A., Gandhi, A. B., Athota, K., Kumar, P. G., & Seth, S. (2022) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-2053 · Cited by 1
Risk factors and pathogenetic mechanisms of genitourinary menopausal syndrome
Orazov, M. R., Silantyeva, E. S., Радзинский, В. Е., Михалева, Л. М., Khamoshina, M. B., Аркадьевна, Х. Е., Dolgov, E. D., & Balan, P. V. (2023) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20232304144 · Cited by 1
PROBIOTICS IN RHEUMATIC DISEASES: A SYSTEMATIC REVIEW
Гонсалвеш, К., Маседо, Х., Фернандеш, Л., Churilov, L. P., & Карвалью, Ж. Ф. Д. (2023) · Russian Biomedical Research · doi:10.56871/rbr.2023.39.42.011 · Cited by 1
Evaluation of Probiotics and Safety Concerns
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_33 · Cited by 1
Cortés, C., & Casanova, J. M. (2020) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2019.11.007 · Cited by 1
Probiotics: present and future
Никитина, Е. А., Орлова, С. В., & Orlova, A. A. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-21-101-114 · Cited by 1
Oropharyngeal and Vulvovaginal Candidiasis
McCort, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819990-9.00014-7 · Cited by 1
Metadata
- Authors
- Xie, H. Y., Feng, D., Wei, D. M., Mei, L., Chen, H., Wang, X., & Fang, F.
- Affiliations
- People's Hospital of Deyang City; Department of Obstetrics and Gynecology; No. 173, Tai Shan North Road Deyang Sichuan China 618000
- Chengdu Women's and Children's Central Hospital (CN)
- West China Second University Hospital of Sichuan University (CN)
- Sichuan University (CN)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2017-11-23
- Volume
- 2017
- Issue
- 11
- Pages
- CD010496-CD010496
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- PMC
- PMC6486023
- OpenAlex
- W1820393462
- Cited by
- 129
- References
- 80
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 17 · 2023: 17 · 2022: 11 · 2021: 26 · 2020: 21 · 2019: 16 · 2018: 7
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- vaginal candidiasis, probiotics, non-pregnant women, vaginal microbiota, clinical cure, mycological cure, relapse prevention, Lactobacillus
- MeSH terms
- Administration, Intravaginal, Antifungal Agents, Candidiasis, Vulvovaginal, Clotrimazole, Female, Humans, Imidazoles, Miconazole, Recurrence, Fluconazole, Randomized Controlled Trials as Topic, Probiotics, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
