Cited by 94Reproductive tract infections researchProbiotics and Fermented FoodsAntifungal resistance and susceptibility

Randomised Clinical Trial in Women with Recurrent Vulvovaginal Candidiasis: Efficacy of Probiotics and Lactoferrin as Maintenance Treatment

Russo, Rosario, Superti, Fabiana, Karadja, Eugen, De Seta, Francesco·2019·Mycoses

Abstract

BACKGROUND: Vulvovaginal candidiasis (VVC) is a recurrent vaginal condition in childbearing women. OBJECTIVES: The aim of this study was to assess the efficacy of an oral formulation containing Lactobacillus acidophilus GLA-14, Lactobacillus rhamnosus HN001 and bovine lactoferrin on symptoms and recurrence of VVC as adjuvant therapy to topical clotrimazole. PATIENTS/METHODS: Forty-eight women positive for C. albicans, symptoms of VVC and documented history of recurrences were randomised into 2 groups receiving verum or placebo (2 capsules/day for 5 days followed by 1 capsule/day for additional 10 days) as adjuvant treatment to clotrimazole (induction phase) followed by a maintenance cycle of 6 months (1 capsule/day verum or placebo for 10 consecutive days each month). Symptoms, overall cure rate and recurrence rate were assessed. RESULTS: After clotrimazole therapy, a significant improvement of symptoms was shown in both groups. However, only women treated with probiotics and lactoferrin showed a significant improvement of itching and discharge at 3 and 6 months. During the six-month follow-up, recurrences were significantly less in the intervention group vs placebo (33.3% vs 91.7% after 3 months and 29.2% vs 100% after 6 months). CONCLUSIONS: The results show that the investigated lactobacilli mixture in combination with lactoferrin represents a safe and effective adjuvant approach for reducing symptoms and recurrences of RVVC.

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Crossref · 10.1111/myc.12883

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  • A randomized trial from 2019 by Russo et al. showed the effectiveness of a Lactobacilli mixture in combination with lactoferrin in reducing symptoms and preventing RVVC recurrence.

    “However, a randomized trial from 2019 by Russo et al. showed the effectiveness of a Lactobacilli mixture in combination with lactoferrin in reducing symptoms and preventing RVVC recurrence [66].”

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Authors
Russo, R., Superti, F., Karadja, E., & De Seta, F.
Affiliations
  • Giellepi SpA (Italy) (IT)
  • Istituto Superiore di Sanità (IT)
  • Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara (RO)
  • Department of Medical Science University of Trieste Trieste Italy
Corresponding author
Russo, Rosario
Venue
Mycoses
Publisher
Wiley
Published
2019-02-20
Volume
62
Issue
4
Pages
328-335
ISSN
  • 0027-5557 (ISSN-L)
  • 0933-7407
  • 1439-0507
OpenAlex
W2904888642
Cited by
94
References
49
Citations by year
2026: 11 · 2025: 8 · 2024: 12 · 2023: 22 · 2022: 14 · 2021: 14 · 2020: 9 · 2019: 4
FWCI
5.45
Type
journal article
Language
en
Open access
closed
Locations
  • Mycoses (publishedVersion)
  • PubMed (publishedVersion)
Funders
Giellepi S.p.A.
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
recurrent vulvovaginal candidiasis, probiotics, lactoferrin, Lactobacillus rhamnosus HN001, clotrimazole, adjuvant therapy, maintenance therapy, Candida albicans, recurrence prevention, vaginal symptoms
MeSH terms
Adolescent, Adult, Animals, Anti-Infective Agents, Candidiasis, Vulvovaginal, Clotrimazole, Double-Blind Method, Female, Humans, Lactoferrin, Middle Aged, Placebos, Prospective Studies, Treatment Outcome, Probiotics, Secondary Prevention, Young Adult, Chemoradiotherapy, Adjuvant, Maintenance Chemotherapy

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