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Cited by 56Reproductive Health and TechnologiesReproductive System and PregnancyReproductive Health and Contraception

Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination

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Lensen, Sarah F, Manders, Marlies, Nastri, Carolina O, Gibreel, Ahmed, Martins, Wellington P, Templer, Gabriella E, Farquhar, Cindy·2016·Cochrane Database of Systematic Reviews
DOI 10.1002/14651858.cd011424.pub2PMC PMC8094383
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Abstract

Background Intentional endometrial injury is currently being proposed as a technique to improve the probability of pregnancy in women undergoing assisted reproductive technologies (ART) such as in vitro fertilisation (IVF). Endometrial injury is often performed by pipelle biopsy or a similar technique, and is a common, simple, gynaecological procedure that has an established safety profile. However, it is also known to be associated with a moderate degree of discomfort/pain and requires an additional pelvic examination. The effectiveness of this procedure outside of ART, in women or couples attempting to conceive via sexual intercourse or with low complexity fertility treatments such as intrauterine insemination (IUI) and ovulation induction (OI), remains unclear. Objectives To evaluate the effectiveness and safety of intentional endometrial injury in subfertile women and couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI). Search methods We searched the Cochrane Gyanecology and Fertility Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS, DARE, ISI Web of Knowledge and ClinicalTrials.gov; as well as reference lists of relevant reviews and included studies. We performed the searches from inception to 31 October 2015. Selection criteria We included randomised controlled trials (RCTs) that evaluated any kind of intentional endometrial injury in women planning to…

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Crossref · 10.1002/14651858.cd011424.pub2

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4 of 4 references verified0 citation errors · 0 not checkable

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  • A Cochrane review found no evidence of a difference in miscarriage rate per clinical pregnancy with endometrial scratch/injury prior to intrauterine insemination or sexual intercourse (RR 0.73, 95% CI 0.38-1.39; six RCTs, 174 participants; I2=0%).

    “A Cochrane review assessing women undergoing endometrial scratch/injury prior to intrauterine insemination or sexual intercourse found no evidence of a difference in miscarriage rate per clinical pregnancy (RR 0.73, 95% CI 0.38-1.39;six RCTs, 174 participants; I 2 statistic = 0%;).207”

    From Recurrent MiscarriageGreen‐top Guideline No. 17 (2023) · cites this paper as [207]

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Authors
Lensen, S. F., Manders, M., Nastri, C. O., Gibreel, A., Martins, W. P., Templer, G. E., & Farquhar, C.
Affiliations
  • University of Auckland (NZ)
  • Radboud University Medical Center (NL)
  • Universidade de São Paulo (BR)
  • Mansoura University (EG)
ORCID
Venue
Cochrane Database of Systematic Reviews
Publisher
Wiley
Published
2016-06-14
Volume
3
Issue
6
Pages
CD011424-CD011424
ISSN
  • 1361-6137 (ISSN-L)
  • 1465-1858
DOI
10.1002/14651858.cd011424.pub2
PMC
PMC8094383
OpenAlex
W1912669516
Cited by
56
References
4
Citations by year
2024: 2 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 2
FWCI
1.29
Type
journal article
Language
en
Update notices
new_version (2021-03-18)
Open access
Locations
  • Cochrane Database of Systematic Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Keywords
endometrial injury, endometrial scratching, intrauterine insemination, unexplained infertility, spontaneous conception, live birth rate, ongoing pregnancy, ovulation induction, assisted reproduction, sham procedure, endometrial receptivity, endometrial receptivity array, endometrial receptivity testing
MeSH terms
Abortion, Spontaneous, Adult, Coitus, Endometrium, Female, Fertilization in Vitro, Humans, Infertility, Pain, Pain Measurement, Pregnancy, Pregnancy Rate, Reproductive Techniques, Assisted, Live Birth

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