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Cited by 93Cell Adhesion Molecules ResearchCellular Mechanics and InteractionsBiochemical and Structural Characterization

The tale of two talins – two isoforms to fine‐tune integrin signalling

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Gough, Rosemarie E., Goult, Benjamin T.·2018·FEBS Letters
DOI 10.1002/1873-3468.13081PMC PMC6032930
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Abstract

Talins are cytoplasmic adapter proteins essential for integrin‐mediated cell adhesion to the extracellular matrix. Talins control the activation state of integrins, link integrins to cytoskeletal actin, recruit numerous signalling molecules that mediate integrin signalling and coordinate recruitment of microtubules to adhesion sites via interaction with KANK (kidney ankyrin repeat‐containing) proteins. Vertebrates have two talin genes, TLN 1 and TLN 2. Although talin1 and talin2 share 76% protein sequence identity (88% similarity), they are not functionally redundant, and the differences between the two isoforms are not fully understood. In this Review, we focus on the similarities and differences between the two talins in terms of structure, biochemistry and function, which hint at subtle differences in fine‐tuning adhesion signalling.

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  • TLN2 is a cytoplasmic adapter protein essential for integrin-mediated cell adhesion to the extracellular matrix.

    “TLN2 is a cytoplasmic adapter protein essential for integrin-mediated cell adhesion to the extracellular matrix [35].”

    From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [35]

    The Abstract describes talins as cytoplasmic adapter proteins essential for integrin-mediated adhesion and identifies TLN2 as one of two talin genes. But “The talins” section says talin2 is absent from some cell types and that adhesion is completely lost when both isoforms are knocked out. The copy supports TLN2’s identity and role, but not the claim that TLN2 individually is essential for cell–ECM adhesion. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Gough, R. E., & Goult, B. T.
Affiliations
University of Kent (GB)
Corresponding author
Goult, Benjamin T.
ORCID
Venue
FEBS Letters
Publisher
Wiley
Published
2018-05-18
Volume
592
Issue
12
Pages
2108-2125
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1002/1873-3468.13081
PMC
PMC6032930
OpenAlex
W2802947309
Cited by
93
References
3
Citations by year
2026: 3 · 2025: 12 · 2024: 10 · 2023: 9 · 2022: 9 · 2021: 21 · 2020: 17 · 2019: 8 · 2018: 4
FWCI
1.84
Type
journal article
Language
en
Open access
Licence
Locations
  • FEBS Letters (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • Kent Academic Repository (University of Kent) (acceptedVersion)
Funders
  • Biotechnology and Biological Sciences Research Council (BB/N007336/1)
  • Human Frontier Science Program (RGP00001/2016)
  • University of Kent
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords
talin, talin-1, integrin signaling, integrin-mediated adhesion, extracellular matrix, actin cytoskeleton, adaptor proteins
MeSH terms
Animals, Cell Membrane, Humans, Models, Molecular, Protein Conformation, Signal Transduction, Integrins, Talin, Sequence Homology, Amino Acid, Protein Isoforms

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