The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Targeting immunogenic cell death in cancer
Open accessAbstract
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic therapy, and radiotherapy. It involves the activation of the immune system against cancer in immunocompetent hosts. ICD comprises the release of damage‐associated molecular patterns (DAMPs) from dying tumor cells that result in the activation of tumor‐specific immune responses, thus eliciting long‐term efficacy of anticancer drugs by combining direct cancer cell killing and antitumor immunity. Remarkably, subcutaneous injection of dying tumor cells undergoing ICD has been shown to provoke anticancer vaccine effects in vivo. DAMPs include the cell surface exposure of calreticulin (CRT) and heat‐shock proteins (HSP70 and HSP90), extracellular release of adenosine triphosphate (ATP), high‐mobility group box‐1 (HMGB1), type I IFNs and members of the IL‐1 cytokine family. In this review, we discuss the cell death modalities connected to ICD, the DAMPs exposed during ICD, and the mechanism by which they activate the immune system. Finally, we discuss the therapeutic potential and challenges of harnessing ICD in cancer immunotherapy.
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1 retracted
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Self-citationImmunogenic Cell Death in Cancer Therapy
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Calreticulin exposure dictates the immunogenicity of cancer cell death
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Oncolytic virotherapy: basic principles, recent advances and future directions
Lin, D., Shen, Y., & Liang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01407-6 · Cited by 459
CD39/CD73/A2AR pathway and cancer immunotherapy
Xia, C., Yin, S., To, K. K. W., & Fu, L. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01733-x · Cited by 399
Deng, S., Vlatkovic, T., Li, M., Zhan, T., Veldwijk, M. R., & Herskind, C. (2022) · Cancers · doi:10.3390/cancers14194874 · Cited by 62
Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy
Ji, P., Sun, W., Zhang, S., Xing, Y., Wang, C., Wei, M., Li, Q., Ji, G., & Yang, G. (2023) · Advanced Science · doi:10.1002/advs.202301789 · Cited by 57
Wang, Y., Tang, Q., Wu, R., Yang, S., Geng, Z., He, P., Li, X., Chen, Q., & Liang, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c11174 · Cited by 49
Metadata
- Authors
- Ahmed, A., & Tait, S. W. G.
- Venue
- Molecular Oncology
- Publisher
- Wiley
- Published
- 2020-12
- Volume
- 14
- Issue
- 12
- Pages
- 2994-3006
- ISSN
- 1574-7891 (ISSN-L)
- 1878-0261
- OpenAlex
- W3104958039
- Cited by
- 930
- References
- 19
- FWCI
- 26.23
- Type
- journal article
- Language
- en
- Open access
- gold
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