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Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology
Abstract
PART I: GENE AND PROTEIN STRUCTURE 1 Gene Structure 2 Developmental Expression 3 Gene Regulation 4 Protein Structure and Functional Domains 5 Enzymatic Properties 6 Epitope Maps PART II: IN VIVO FUNCTIONS 7 The In Vivo Role of TNAP 8 Knockout Mouse Models PART III: AP EXPRESSION IN HEALTH AND DISEASE 9 APs as Physiological and Disease Markers 10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Isozymes PART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY 11 Applications of Recombinant APs 12 Use of APs in Prodrug Converting Strategies 13 APs as Therapeutic Agents 14 APs in the Food Industry 15 Veterinary Uses of AP Determinations 16 Methodologies
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“Although polyP depolymerization is thermodynamically favored in aqueous environments, the kinetics are slow at neutral pH [29], but accelerated by phosphatase enzymes such as alkaline phosphatase (APase) [30].”
From A Review of Phosphate Mineral Nucleation in Biology and Geobiology (2013) · cites this paper as [30]
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- Authors
- Millán, J. L.
- Venue
- Wiley eBooks
- Publisher
- Wiley
- Published
- 2006-01-09
- OpenAlex
- W625374770
- Cited by
- 421
- References
- 91
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- FWCI
- 32.05
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- en
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- Wiley eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- tissue-nonspecific alkaline phosphatase, placental alkaline phosphatase, GCAP, IAP, isozymes, gene structure, developmental gene expression, gene expression regulation, protein structure, enzyme properties, epitope mapping, knockout mouse models, disease markers, prodrug activation, therapeutic enzymes, food industry applications, veterinary diagnostics
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