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Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation
Abstract
Correlation between light, mostly fluorescence, and electron microscopy (EM) is needed to identify biological molecules within their ultrastructural context and/or to relate the ultrastructure to preceding dynamics of biological molecules. Recent development of labels, sample preparation techniques, and microscopy tools allow researchers to bridge the gap between these two modalities, while dedicated, integrated microscopes merge the two techniques into one. This not only allows broader possibilities for implementation of CLEM (correlative light and electron microscopy) in analytical sciences but also enables novel applications crossing boundaries between the traditional microscopes. We provide an overview of the different CLEM approaches, including common labels and sample preparation techniques, and focus attention specifically on the advanced instrumentation and the novel opportunities and challenges these bring for the chemical and biological sciences.
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DNA Excited-State Dynamics: From Single Bases to the Double Helix
Middleton, C. T., de La Harpe, K., Su, C., Law, Y. K., Crespo-Hernández, C. E., & Kohler, B. (2009) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.59.032607.093719 · Cited by 827
Real-Time Probing of Electron Dynamics Using Attosecond Time-Resolved Spectroscopy
Ramasesha, K., Leone, S. R., & Neumark, D. M. (2016) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040215-112025 · Cited by 225
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Ahmad, M., Lee, S. S., Dou, X., Mohan, D., Sung, J.-K., Yang, J. E., & Ok, Y. S. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.05.042 · Cited by 1,357
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Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 678
Metadata
- Venue
- Wiley eBooks
- Publisher
- Wiley
- Published
- 2006-09-15
- OpenAlex
- W3035579699
- Cited by
- 7,403
- References
- 2
- Type
- reference entry
- Language
- en
- Open access
- closed
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