Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators

Spiegelman, Bruce M.

doi:10.1002/9780470725207.ch5

Cited by 187Adipose Tissue and MetabolismMitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators

Spiegelman, Bruce M.·2007·Novartis Foundation Symposia

DOI 10.1002/9780470725207.ch5

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Abstract

The PGC1 transcriptional coactivators are major regulators of several crucial aspects of energy metabolism. PGC1alpha controls many aspects of oxidative metabolism, including mitochondrial biogenesis and respiration through the coactivation of many nuclear receptors, and factors outside the nuclear receptor family. ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial biogenesis. We have recently addressed the question of the role of PGC1 coactivators in the metabolism of reactive oxygen species (ROS). We now show that PGC1alpha and beta are induced when cells are given an oxidative stressor, H2O2. In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. Mice deficient in PGC1alpha get excessive neurodegeneration when given kainic acid-induced seizures or MPTP, which causes Parkinsonism. These data show that the PGC1s are key modulators of mitochondrial biology and important protective molecules against ROS generation and damage. The implications of this for diabetes and neurodegenerative diseases are discussed.

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PGC-1α, a powerful regulator of mitochondrial oxidative metabolism, shows marked declines with aging.
“peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), a powerful regulator of mitochondrial oxidative metabolism,(Liang and Ward 2006;Russell 2005;Spiegelman 2007) shows marked declines with aging.(Corton and Brown-Borg 2005;Ling, Poulsen, Carlsson, Ridderstrale, Almgren, Wojtaszewski, Beck-Nielsen, Groop, and Vaag 2004)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Spiegelman 2007

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Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
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Background
Retinol Binding Protein 4 Stimulates Hepatic Sterol Regulatory Element-Binding Protein 1 and Increases Lipogenesis Through the Peroxisome Proliferator-Activated Receptor-γ Coactivator 1β-Dependent Pathway
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“The anterograde intergenomic regulatory circuit involves nonmitochondrial signals that activate nuclear transcription factors to regulate both nuclear and mitochondrial gene expression (Poyton and McEwen, 1996; Kelly and Scarpulla, 2004; Spiegelman, 2007).”
Background
Cardio-Metabolic Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)
Reyskens, K. M. S. E., Fisher, T.-L., Schisler, J. C., O'Connor, W. G., Rogers, A. B., Willis, M. S., Planesse, C., Boyer, F., Rondeau, P., Bourdon, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073347 · Cited by 54 · see citing works
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Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review
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BackgroundInfluential
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The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism
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Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes
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Background
Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease
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“ATGL rescues renal endocytic dysfunction via the PGC1α pathway This study reveals that ATGL/Bmm rescues HFD-induced dysfunction in Drosophila renal cells via a mechanism that requires GABPA/Delg and also PGC1α/Srl, a conserved regulator of mitochondrial biogenesis, membrane potential, and ß-oxidation [49,50].”
BackgroundMethod
Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways
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“Indeed, PGC-1α interacts with and co-activates numerous transcription factors and nuclear receptors, including estrogen-related receptor-α (ERRα), nuclear respiratory factor-1 (NRF-1) and 2, myocyte enhancer factor 2 (MEF2), and mitochondrial transcription factor A (Tfam) (Spiegelman, 2007).”
Background
Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability
Fu, Z., Liu, F., Liu, C., Jin, B., Jiang, Y., Tang, M., Qi, X., & Guo, X. L. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.015 · Cited by 41 · see citing works
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Ginseng treatment reverses obesity and related disorders by inhibiting angiogenesis in female db/db mice
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Method
Protective Role ofPsoralea corylifoliaL. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
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Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice
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Mitochondrial DNA replication and repair defects: Clinical phenotypes and therapeutic interventions
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MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells
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AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
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“PGC1 and PGC1 (PGC1 / ) and ERR / / isoforms interact in several combinations to form transcriptional coactivator and transcription factor complexes that regulate hundreds of genes and promote a diverse variety of phenotypes (18, 19).”
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MicroRNA‑33 regulates the NLRP3 inflammasome signaling pathway in macrophages
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“1 3 reactive oxygen species [28].”

Authors: Spiegelman, B. M.
Affiliations: Harvard University (US)
Corresponding author: Spiegelman, Bruce M.
ORCID: Spiegelman, Bruce M.
Venue: Novartis Foundation Symposia
Publisher: Wiley
Published: 2007-10-05
Volume: 287
Pages: 60-69
ISSN: 1528-2511 (ISSN-L)
1935-4657
DOI: 10.1002/9780470725207.ch5
OpenAlex: W1589792898
Cited by: 187
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 11 · 2017: 11 · 2016: 7 · 2015: 16 · 2014: 14 · 2013: 14 · 2012: 17
Type: other
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Novartis Foundation symposium (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: PGC-1α, PGC-1β, mitochondrial bioenergetics, mitochondrial biogenesis, oxidative stress, reactive oxygen species, reactive oxygen species scavenging, nuclear receptors, estrogen-related receptor alpha, NRF1, Nrf2, catalase, glutathione peroxidase 1, manganese superoxide dismutase, oxidative stress-induced cell death, neurodegeneration, Parkinson's disease, MPTP, kainic acid-induced seizures, diabetes mellitus
MeSH terms: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Energy Metabolism, Humans, Mitochondria, Transcription Factors, Transcription, Genetic, Trans-Activators, Reactive Oxygen Species, Oxidative Stress, Neurodegenerative Diseases

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Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators

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