The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Biotransformation of Xenobiotics
Abstract
Xenobiotics, which are absorbed into biological systems by passive diffusion across membranes are usually lipid soluble and not ideally suited for excretion. Indeed very lipophilic substances may remain in the mammalian body for many years. After a xenobiotic has been absorbed, it may undergo biotransformation to products which are rapidly excreted and therefore elimination of the compound from the animal is facilitated. However, biotransformation may also change the biological activity of the substance. Hence, the metabolic fate of the compound can have an important bearing on its toxic potential, the disposition of the compound in the body and the excretion of the compound. The metabolic reactions involved are usually divided into phase 1 and phase 2 reactions, the latter being conjugation reactions. The products of metabolism are usually more water soluble than the original compound. Although usually detoxifying, these reactions, especially phase 1 ones, sometimes increase toxicity.
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Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785
Ecological effects, transport, and fate of mercury: a general review
Boening, D. W. (2000) · Chemosphere · doi:10.1016/s0045-6535(99)00283-0 · Cited by 1,841
Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model
Weber, L. W. D., Boll, M., & Stampfl, A. (2003) · Critical Reviews in Toxicology · doi:10.1080/713611034 · Cited by 1,777
Cytochrome P450 and Chemical Toxicology
Guengerich, F. P. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700079z · Cited by 1,725
NELSON, D. R., KAMATAKI, T., WAXMAN, D. J., GUENGERICH, F. P., ESTABROOK, R. W., FEYEREISEN, R., GONZALEZ, F. J., COON, M. J., GUNSALUS, I. C., GOTOH, O., et al. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.1 · Cited by 1,655
Martignoni, M., Groothuis, G. M. M., & de Kanter, R. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.6.875 · Cited by 1,478
The molecular biology of cytochrome P450s
Gonzalez, F. J. (1988) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00021-3 · Cited by 1,301
POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
Mahgoub, A., Dring, L. G., Idle, J. R., Lancaster, R., & Smith, R. L. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91430-1 · Cited by 1,183
Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases
Armstrong, R. N. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960072x · Cited by 1,143
ACETAMINOPHEN-INDUCED HEPATOTOXICITY
James, L. P., Mayeux, P. R., & Hinson, J. A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.12.1499 · Cited by 1,033
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Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways
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Metadata
- Authors
- Timbrell, J. A., & Marrs, T. C.
- Venue
- General, Applied and Systems Toxicology
- Publisher
- Wiley
- Published
- 2009-10-23
- OpenAlex
- W2125768955
- Cited by
- 435
- References
- 145
- Type
- other
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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