Availability, Standardization and Safety of Human Cells and Tissues for Drug Screening and Testing
Abstract
This chapter contains sections titled: Introduction Availability of Human Cells and Tissues for In-Vitro Testing Selecting a Cell-Based System Considering the Options for Human Cell-Based Testing Establishing a Method Based on an Existing Human Cell Line Developing New or Improved Cell Line-Based Techniques Using Donated Human Tissue Standardization of Cells and Tissues for Testing Purposes Standardization of Primary Cells and Tissues Standardization of Cell Lines Challenges for Standardization of Cell Lines Achieving Standardization of Cell Lines Safety Issues Hazards Associated with Human Cells and Tissues Risks from Cell Lines The Validation of Cell- and Tissue-Based Assays Conclusions and Future Prospects References
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Such assays for qualifying new batches of primary cells may include morphology, histochemistry, cell markers, specific tissue function, and cell-cell/matrix interactions.
“Such assays may include morphology, histochemistry, cell markers, specific tissue function, and cell-cell/matrix interactions (Stacey and Hartung, 2006).”
From Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0) (2021) · cites this paper as Stacey and Hartung, 2006
Cited by
Sorted by citations
Guidance Document on Good In Vitro Method Practices (GIVIMP)
OECD (2018) · OECD Series on Testing and Assessment · doi:10.1787/9789264304796-en · Cited by 161 · see citing works
Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0)
Pamies, D. (2021) · ALTEX · doi:10.14573/altex.2111011 · Cited by 100 · see citing works
- Authors
- Stacey, G. N., & Hartung, T.
- Venue
- Drug Testing in vitro
- Publisher
- Wiley
- Published
- 2006-10-20
- Pages
- 229-250
- Cited by
- 0
- References
- 0
- Language
- en
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