Enzyme Catalysis in Organic Synthesis: A Comprehensive Handbook

Abstract

VOLUME 1 PART I PRINCIPLES OF ENZYME CATALYSIS Introduction - Principles and Historical Landmarks of Enzyme Catalysis in Organic Synthesis Concepts in Biocatalysis Discovery of Enzymes Rational Design of Enzymes Directed Evolution of Enzymes Production and Isolation of Enzymes Reaction and Process Engineering PART II HYDROLYSIS AND FORMATION OF C-O BONDS Hydrolysis and Formation of Carboxylic Acid Esters Hydrolysis and Formation of Epoxides Hydrolysis and Formation of Glycosidic Bonds Addition of Water to C C Bonds and its Elimination Industrial Application and Processes Forming C-O Bonds VOLUME 2 PART III HYDROLYSIS AND FORMATION OF C-N BONDS Hydrolysis of Nitriles to Amides Hydrolysis of Nitriles to Carboxylic Acids Hydrolysis of Amides Hydrolysis and Formation of Hydantoins Hydrolysis and Synthesis of Peptides C-N Lyases Catalyzing Addition of Ammonia, Amines, and Amides to C C and C O Bonds Application of Transaminases Industrial Applications and Processes Using Enzymes Acting on C-N Bonds PART IV FORMATION AND CLEAVAGE OF C-C BONDS Aldol Reactions Acyloin and Benzoin Condensations Cleavage and Formation of Cyanohydrins Industrial Application and Processes Using Carbon-Carbon Lyases PART V HYDROLYSIS AND FORMATION OF P-O BONDS Hydrolysis and formation of P-O Bonds PART VI REDUCTIONS Reduction of Ketones and Aldehydes to Alcohols Reduction of C C Double Bonds Reductive Amination of Keto Acids Industrial Application of Oxidoreductase catalyzed Reduction of Ketones and Aldehydes VOLUME 3 PART VII OXIDATIONS Oxyfunctionalization of C-H Bonds Oxyfunctionalization of C-C Multiple Bonds Oxidation of Alcohols, Aldehydes, and Acids Baeyer-Villiger Oxidations Aromatic Oxidations Oxidation of C-N Bonds Oxidation at Sulfur and Oxidation of Amino Groups Halogenation Industrial Application and Processes Using Biocatalysts for Oxidation Reactions PART VIII ISOMERIZATIONS Isomerizations Industrial Application and Processes Using Isomerases PART IX EXTENDED APPLICATIONS OF ENZYME CATALYSIS Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed Reactions Catalytic Antibodies Chemoenzymatic Dynamic Kinetic Resolution and Related Dynamic Asymmetric Transformations Biocatalysis in Material Science Industrial Applications of Enzymes in Emerging Areas PART X TABULAR SURVEY OF AVAILABLE ENZYMES Tabular Survey of Available Enzymes