Preliminary Evidence of Altered Biomechanics in Adolescents With Juvenile Fibromyalgia
Open accessAbstract
Objective: Juvenile fibromyalgia (FM) is characterized by chronic musculoskeletal pain and marked reduction in physical activity. Despite recommendations for exercise to manage juvenile FM pain, exercise adherence is poor. Because of pain and activity avoidance, adolescents with juvenile FM are at risk for altered joint mechanics that may make them susceptible to increased pain and reduced tolerance for exercise. The primary aim of this study was to assess functional deficits in patients with juvenile FM compared to healthy controls using objective biomechanical assessment. Methods: Female adolescent patients with juvenile FM (n = 17) and healthy controls (n = 14) completed biomechanical assessments, including gait analysis and tests of lower extremity strength (isokinetic knee extension/flexion and hip abduction) and functional performance (drop vertical jump test) along with self‐reported measures of disability (Functional Disability Inventory), pain intensity, depressive symptoms (Children's Depression Inventory), and fear of movement (Tampa Scale of Kinesiophobia). Results: Patients with juvenile FM demonstrated mild deficiencies in walking gait and functional performance (P < 0.05 for both) and significantly lower left knee extension and flexion strength (18–22% deficit) and bilateral hip abduction strength (34–38%) compared with healthy controls (P < 0.008 for all). Patients with juvenile FM reported significantly higher functional disability, pain intensity, depressive symptoms, and fear of movement relative to controls (P < 0.01 for all). Conclusion: This study showed that adolescents with juvenile FM exhibited objective alterations in biomechanics and self‐reported fear of movement that may have reinforced their activity avoidance. Interventions for juvenile FM should include a focus on correcting functional deficits and instilling greater confidence in adolescents with juvenile FM to engage in exercise to improve functional outcomes.
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Kinesiophobia was reported in patients with FM due to the association between pain, fatigue and movement, and was associated with reduced levels of physical activity, increased disability, and perpetuation of pain.
“Kinesiophobia was reported in patients with FM due to the association between pain, fatigue and movement, and was associated with reduced levels of physical activity, increased disability, and perpetuation of pain.17,29,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results (Physical and Psychosocial Functioning; page unavailable) report marked fear of movement in adolescents with juvenile fibromyalgia. The Discussion (page unavailable) describes a possible cycle of pain-related fear, activity avoidance, disability, and pain, but does not establish that kinesiophobia arises from an association between pain, fatigue, and movement. The claim also states the activity and pain consequences more definitively than the paper does. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPatients with FM present with slower gait speed, reduced stride length, delayed gait initiation, altered postural sway, and altered muscle activation patterns during walking.
“Patients with FM present with slower gait speed, reduced stride length, delayed gait initiation, altered postural sway,2,21 and altered muscle activation patterns during walking.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results (Biomechanical and Biodynamic Assessments; page unavailable) report shorter self-selected strides in adolescents with juvenile fibromyalgia, but no significant difference in walking speed. The paper does not report delayed gait initiation or altered postural sway, and its adolescent findings do not establish those claims for FM patients generally. Muscle activation patterns are attached to a separate citation in the citing sentence. (LLM, conf=0.90)
Experimental — accuracy not yet measuredRegular moderate to vigorous physical activity and weight-bearing exercises are recommended for pain management in patients with FM, but adherence to these recommendations is often poor.
“Regular moderate to vigorous physical activity and weight-bearing exercises are recommended for pain management in patients with FM,5,21 but adherence to these recommendations is often poor.9,17,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The passage labeled Abstract > Conclusions recommends moderate-to-vigorous activity and muscle-strengthening exercises at least twice weekly for pain management in juvenile fibromyalgia. The citing sentence attributes the exercise recommendation to this source, but broadens the population to FM generally and substitutes weight-bearing exercises for muscle strengthening. Its separate claim about poor adherence is attached to other citations. (LLM, conf=0.84)
Experimental — accuracy not yet measuredObserved biomechanics include reduced trunk flexion, increased hip flexion, and poor proximal stabilization, all of which contribute to fall risk.
“Observed biomechanics include reduced trunk flexion, increased hip flexion, and poor proximal stabilization, all of which contribute to fall risk.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Discussion (page not provided) describes decreased trunk flexion and increased hip flexion during landing, and suggests these deficits may indicate reduced proximal stabilization. The paper discusses fall risk in connection with biodynamic deviations generally, but does not establish that all three specified findings contribute to falls; its discussion of these landing findings instead mentions jump height and possible injury risk. (LLM, conf=0.88)
Experimental — accuracy not yet measuredGait and postural control deficits were observable even after adjusting for BMI, indicating disease-specific mechanisms.
“However, gait and postural control deficits were observable even after adjusting for BMI, indicating disease-specific mechanisms.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results (Sample Characteristics; page unavailable) report that a normal-BMI subgroup showed differences consistent with the full sample, and the Discussion says functional deficits, including altered gait, were evident beyond group differences in BMI. The paper did not report a formal BMI-adjusted analysis or directly assess postural control, and it does not establish a disease-specific mechanism. (LLM, conf=0.88)
Experimental — accuracy not yet measured
FM patients show reduced muscle strength and altered joint mechanics during functional movements like jumping.
“FM patients show reduced muscle strength and altered joint mechanics during functional movements like jumping.21,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results report reduced knee and hip strength in adolescents with juvenile fibromyalgia, and the Discussion describes altered knee mechanics during a drop vertical jump. The claim says “FM patients” generally, but this study directly tested adolescents with juvenile fibromyalgia, not FM patients across age groups. (LLM, conf=0.82)
Experimental — accuracy not yet measuredKinesiophobia may contribute to altered gait through decreased walking speed, weakened muscle strength, and reduced performance in physical tasks.
“Kinesiophobia may also contribute to altered gait, due to decreased walking speed, weakened muscle strength, and reduced performance in physical tasks.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Discussion (page unavailable) names fear of movement as a possible reason for altered gait in adolescents with juvenile fibromyalgia and reports associations between fear and slower walking, weaker strength, and poorer physical-task performance in adults with other chronic pain conditions. It does not establish that those three factors mediate fear’s effect on gait; the Results (page unavailable) also found no significant difference in self-selected walking speed between the adolescent groups. (LLM, conf=0.84)
Experimental — accuracy not yet measuredBalance confidence, decreased muscle strength and altered biomechanics can negatively affect patients' quality of life by increasing the risk of falling, fall-related injuries and fear of falling.
“Balance confidence, decreased muscle strength and altered biomechanics can negatively affect patients’ quality of life by increasing the risk of falling, fall-related injuries and fear of falling,9,17,19,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results report reduced knee and hip strength and altered gait in adolescents with juvenile fibromyalgia. The Discussion links altered mechanics to possible injury risk and reports increased fall risk in adults with fibromyalgia. It does not establish that these factors increase fall-related injuries or fear of falling, or that those outcomes reduce quality of life; its discussion of fear concerns movement and pain. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe literature is mixed in implicating obesity concerning motor control and postural stability.
“However, the literature is mixed in implicating obesity concerning motor control and postural stability.2,17,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Results (Sample Characteristics; page unavailable) report that movement-related deficits persisted in adolescents with juvenile fibromyalgia and controls whose BMI was in the normal range. The Discussion likewise says the deficits were evident beyond group differences in BMI. This bears on whether body mass explains motor-control differences, but the paper does not establish that the literature is mixed about obesity and postural stability. (LLM, conf=0.76)
Experimental — accuracy not yet measuredKinesiophobia and pain catastrophizing compound activity avoidance and contribute to functional deficits and physical deconditioning in fibromyalgia.
“further compounding activity avoidance and contributing to functional deficits and physical deconditioning.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The introduction (page unavailable) says pain-related fear may reinforce activity avoidance, contribute to functional deficits, and further contribute to physical deconditioning. The Conclusions also link fear of movement to activity avoidance in adolescents with juvenile fibromyalgia. Our copy does not address pain catastrophizing, and it presents these links as possibilities rather than established causal effects. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMotor assessment can be used to assess the effectiveness of training programs in improving physical functioning in patients with fibromyalgia.
“Motor assessment can be used to assess the effectiveness of training programs in improving physical functioning in patients with FM.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Discussion says biomechanical measures can assess whether integrative training improves physical functioning in patients with juvenile fibromyalgia (JFM). The citing sentence extends that proposed use to patients with fibromyalgia generally, while the paper says its findings are specifically relevant to JFM and may not generalize to other conditions. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAn integrative strategy combining pain-coping skills with tailored, enjoyable exercise that includes sensory and motor challenges holds promise in managing fibromyalgia.
“An integrative strategy combining pain-coping skills, enhanced with tailored, enjoyable exercise that includes sensory and motor challenges specifically designed to improve confidence in movement and enhance activity participation, holds promise in managing FM.2,17,30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
The Discussion (page unavailable) says that combining integrative neuromuscular training with cognitive-behavioral therapy holds promise for adolescents with juvenile fibromyalgia, and describes tailored movement instruction intended to build confidence and support activity. It does not specify enjoyable exercise or sensory challenges, and its proposed approach is limited to juvenile fibromyalgia rather than fibromyalgia generally. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSpecific deficiencies in gait include reduced stride length and alterations in dorsiflexion, eversion, and internal rotation at the knee during early stance.
“Specific deficiencies in gait include reduced stride length and alterations in dorsiflexion, eversion, and internal rotation at the knee during early stance.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
These deficits were accompanied by pain, functional disability, lowered mood, and kinesiophobia.
“These deficits were accompanied by pain, functional disability, lowered mood, and kinesiophobia.30”
From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [30]
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- Authors
- Sil, S., Thomas, S., DiCesare, C., Strotman, D., Ting, T. V., Myer, G., & Kashikar‐Zuck, S.
- Affiliations
- Emory University (US)
- Cincinnati Children's Hospital Medical Center (US)
- ORCID
- Venue
- Arthritis Care & Research
- Publisher
- Wiley
- Published
- 2014-12-27
- Volume
- 67
- Issue
- 1
- Pages
- 102-111
- ISSN
- 0893-7524 (ISSN-L)
- 2151-464X
- 2151-4658
- PMC
- PMC4280314
- OpenAlex
- W1491367019
- Cited by
- 48
- References
- 61
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 2
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arthritis Care & Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21 AR063412)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Keywords
- juvenile fibromyalgia, adolescents, musculoskeletal pain, gait analysis, lower limb strength, knee muscle strength, hip abductor strength, drop vertical jump, functional disability, kinesiophobia, depressive symptoms, exercise adherence, activity avoidance, biomechanics
- MeSH terms
- Adolescent, Biomechanical Phenomena, Child, Disability Evaluation, Female, Fibromyalgia, Gait, Humans, Male, Pain Measurement, Muscle Strength, Self Report
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