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Cited by 403

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Rheumatic and Musculoskeletal Immune‐Related Adverse Events Due to Immune Checkpoint Inhibitors: A Systematic Review of the Literature

Open access
Cappelli, Laura C., Gutierrez, Anna Kristina, Bingham, Clifton O., Shah, Ami A.·2017·Arthritis Care & Research
DOI 10.1002/acr.23177
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Abstract

Objective: Immune checkpoint inhibitors (ICI s) are improving prognoses in advanced stage cancers, but they also lead to immune‐related adverse events (IRAE s). IRAE s targeting many organ systems have been reported, but musculoskeletal and rheumatic IRAE s have not been well‐characterized. We systematically reviewed published literature on musculoskeletal and rheumatic IRAE s to better understand prevalence and clinical characteristics. Methods: Medline and CENTRAL databases were searched for articles reporting rheumatic and musculoskeletal IRAE s secondary to ICI treatment. After screening abstracts and full texts in duplicate, clinical features, prevalence, and treatment data were extracted and summarized. Results: A total of 1,725 unique abstracts were screened; 231 contained original data and were about ICI s and went to full‐text screening. Fifty‐two of these contained information about musculoskeletal or rheumatic IRAE s or about treatment with ICI s in preexisting autoimmune disease. Of these, 33 were clinical trials, 3 were observational studies, and 16 were case reports or series. Arthralgia prevalence in clinical trials ranged 1–43%, and myalgia was reported in 2–20%. Arthritis was reported in 5 of 33 clinical trials, and vasculitis was reported in only 2. One observational study and 3 case reports described patients with preexisting autoimmune disease treated with ICI s. Case reports included development of inflammatory arthritis, vasculitis, myositis, and lupus nephritis. Conclusion: Arthralgia and myalgia have been reported commonly in patients treated with ICI s. The prevalence of rheumatic IRAE s such as inflammatory arthritis, vasculitis, and sicca syndrome is less clear from current evidence. There is limited observational and case‐level evidence describing ICI use in patients with preexisting autoimmune disease.

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Metadata

Authors
Cappelli, L. C., Gutierrez, A. K., Bingham, C. O., & Shah, A. A.
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2017-09-21
Volume
69
Issue
11
Pages
1751-1763
ISSN
  • 0893-7524 (ISSN-L)
  • 2151-464X
  • 2151-4658
DOI
10.1002/acr.23177
OpenAlex
W2565782504
Cited by
403
References
11
FWCI
4.38
Type
journal article
Language
en
Open access
green

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