Does Muscle Strength Change Over Time in Patients With Hypermobile Ehlers‐Danlos Syndrome/Hypermobility Spectrum Disorder? An Eight‐Year Follow‐Up Study
Open accessAbstract
Objective: Reduced maximal muscle strength and strength endurance have been found in patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorder (hEDS/HSD) and are recognized as common associated features of the disorder. However, the extent to which these parameters change over time is currently not documented. Therefore, the purpose of this 8‐year follow‐up study was to investigate this evolution. Methods: Thirty female patients (mean age 41 years) with hEDS/HSD and 17 controls participated at baseline and 8 years later. Maximal muscle strength and strength endurance tests of the knee flexors and extensors, and 2 lower‐extremity posture maintenance tests were performed to evaluate static strength endurance. In addition, muscle mass and density were evaluated by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Results: Maximal muscle strength and strength endurance were significantly lower at both baseline and follow‐up in the hEDS/HSD group compared to the control group (P ≤ 0.007). Maximal muscle strength of the knee flexors (decreased in the control group: pɳ 2 = 0.139), strength endurance of the knee extensors (decreased in the hEDS/HSD group and increased in the control group: pɳ 2 = 0.244), and muscle density (decreased in the hEDS/HSD group: pɳ 2 = 0.263) showed a significantly different evolution over 8 years. No other significant differences in evolution were found. Conclusion: Decreased muscle strength was identified at both time points in patients with hEDS/HSD. The evolution of most muscle strength parameters over time did not significantly differ between groups. Future studies should focus on the effectiveness of different types of muscle training strategies in hEDS/HSD patients.
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Strong evidence for physical therapy is lacking, yet it is the mainstay of management.
“Strong evidence for physical therapy is lacking [39], yet it is the mainstay of management [8, 40, 41].”
From Are patients with hypermobile Ehlers–Danlos syndrome or hypermobility spectrum disorder so different? (2021) · cites this paper as [41]
To improve, treat and prevent musculoskeletal manifestations of joint hypermobility, education, active participation and active physical therapy intervention are recommended.
“Generally, to improve, treat and prevent musculoskeletal manifestations of joint hypermobility, the facets of education, active participation and active physical therapy intervention are recommended. [23, 24, 40–43].”
From Are patients with hypermobile Ehlers–Danlos syndrome or hypermobility spectrum disorder so different? (2021) · cites this paper as [41]
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Researchers in rheumatology should avoid categorization of continuous predictor variables
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Self-citationComplications and Management of Ehlers–Danlos Syndromes and Hypermobility Spectrum Disorders
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“Indeed, many experts in the field combine these conditions into a single phenotype termed hEDS/HSD [5, 72-76].”
Background
- Authors
- Coussens, M., Calders, P., Lapauw, B., Celie, B., Banica, T., De Wandele, I., Pacey, V., Malfait, F., & Rombaut, L.
- Affiliations
- Ghent University (BE)
- Ghent University Hospital (BE)
- Ghent University Hospital Ghent Belgium
- Macquarie University (AU)
- Corresponding author
- Coussens, Marie
- ORCID
- Venue
- Arthritis Care & Research
- Publisher
- Wiley
- Published
- 2021-06-18
- Volume
- 73
- Issue
- 7
- Pages
- 1041-1048
- ISSN
- 0893-7524 (ISSN-L)
- 2151-464X
- 2151-4658
- OpenAlex
- W3016130469
- Cited by
- 11
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arthritis Care & Research (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorders, muscle strength, strength endurance, muscle mass, muscle density, knee flexors, knee extensors, posture maintenance, longitudinal change, female patients
- MeSH terms
- Adult, Ehlers-Danlos Syndrome, Exercise Test, Female, Follow-Up Studies, Humans, Joint Instability, Knee Joint, Longitudinal Studies, Male, Middle Aged, Pain Measurement, Physical Endurance, Time Factors, Exercise Tolerance, Disease Progression, Muscle, Skeletal, Muscle Strength
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