Altered Multisegment Ankle and Foot Kinematics During Gait in Patients With Hypermobile Ehlers‐Danlos Syndrome/Hypermobility Spectrum Disorder: A Case–Control Study
Open accessAbstract
Objective Ankle-foot problems have a considerable impact on daily functioning in patients with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder (hEDS/HSD). Therefore, the objective of this study was to identify alterations in multisegment ankle and foot kinematics during gait and to assess foot function and pain in these patients. Methods Twenty-three women with hEDS/HSD and 23 healthy controls participated in this 3-dimensional gait analysis. Multisegment ankle and foot kinematics were collected using the Ghent Foot Model and analyzed with Statistical Parametric Mapping. Foot function and pain were assessed using visual analog scale scores, the Margolis Pain Diagram, and the Foot Function Index. Results Levels of pain and foot dysfunction were significantly higher in subjects with hEDS/HSD (P Conclusion This study is the first to apply a multisegment foot model during gait in hEDS/HSD, which confirms the characteristic hypermobility throughout the foot, especially the hypermobile first ray.
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hEDS and HSD are gathered in the same category for research purposes.
“or are gathered in the same category for research purposes [25, 26].”
From Are patients with hypermobile Ehlers–Danlos syndrome or hypermobility spectrum disorder so different? (2021) · cites this paper as [26]
Cites
The 2017 international classification of the Ehlers–Danlos syndromes
Malfait, F., Francomano, C., Byers, P., Belmont, J., Berglund, B., Black, J., Bloom, L., Bowen, J. M., Brady, A. F., Burrows, N. P., et al. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31552 · Cited by 1,936 · cited 2× · see citing works
“positive family history, recurrent joint luxations or subluxations or joint instability, and musculoskeletal pain (1).”
BackgroundSelf-citationA framework for the classification of joint hypermobility and related conditions
Castori, M., Tinkle, B., Levy, H., Grahame, R., Malfait, F., & Hakim, A. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31539 · Cited by 602 · cited 1× · see citing works
“labeled as having hypermobility spectrum disorder (HSD) (2).”
BackgroundSelf-citationRombaut, L., Malfait, F., Cools, A., De Paepe, A., & Calders, P. (2010) · Disability and Rehabilitation · doi:10.3109/09638280903514739 · Cited by 236 · see citing works
Self-citationRombaut, L., Scheper, M., De Wandele, I., De Vries, J., Meeus, M., Malfait, F., Engelbert, R., & Calders, P. (2015) · Clinical Rheumatology · doi:10.1007/s10067-014-2499-0 · Cited by 91 · see citing works
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Aubry-Rozier, B., Schwitzguebel, A., Valerio, F., Tanniger, J., Paquier, C., Berna, C., Hügle, T., & Benaim, C. (2021) · Rheumatology International · doi:10.1007/s00296-021-04968-3 · Cited by 66 · see citing works
“In the same vein, very recent studies consider that hEDS and HSD exist on the same physiological continuum (hEDS being a more marked form) [22], require the same pattern of multidisciplinary intervention [23, 24], or are gathered in the same category for research purposes [25, 26].”
Background
- Authors
- Vermeulen, S., De Mits, S., De Ridder, R., Calders, P., De Schepper, J., Malfait, F., & Rombaut, L.
- Affiliations
- Ghent University (BE)
- Ghent University Hospital and Artevelde University of Applied Sciences Ghent Belgium
- Ghent University Ghent Belgium
- Artevelde University of Applied Sciences Ghent Belgium
- Ghent University Hospital (BE)
- Corresponding author
- Rombaut, Lies
- Venue
- Arthritis Care & Research
- Publisher
- Wiley
- Published
- 2022-03-17
- Volume
- 74
- Issue
- 5
- Pages
- 841-848
- ISSN
- 0893-7524 (ISSN-L)
- 2151-464X
- 2151-4658
- OpenAlex
- W3110606542
- Cited by
- 10
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Arthritis Care & Research (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Foot and Ankle Surgery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorders, ankle kinematics, foot kinematics, gait, first ray hypermobility, foot pain, foot function, three-dimensional gait analysis
- MeSH terms
- Ankle, Biomechanical Phenomena, Ehlers-Danlos Syndrome, Female, Gait, Humans, Pain, Case-Control Studies
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