Biotolerability of Intracortical Microelectrodes
Abstract
The major prerequisite for the clinical application of intracortical microelectrodes, or any other neural implant, is that the organism accepts them without causing an unacceptable degree of harm. However, all biomaterials, even those thought to be highly biocompatible, provoke a biological response and some degree of encapsulation. This means that the body can tolerate them, although they are not fully compatible. Therefore, a significant goal is to improve the knowledge and understanding of the interaction between the implanted devices and the local cellular environment in order to improve the long‐term biotolerability, applicability, and functional perspectives of intracortical microelectrode arrays. In this article, some of the main challenges in this field that involves biomaterials science, bioengineering, neurology, neurosurgery, and neuroscience research are discussed.
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The results suggest that silicon-based, penetrating microelectrode arrays could provide the stability required in a clinical device.
“The results therefore suggest that silicon-based, penetrating microelectrode arrays could provide the stability required in a clinical device (11, 32-34) but further investigations in more subjects and over a longer period of time are needed.”
From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [33]
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References 190 · Cited by 11
- Authors
- Fernández, E., & Botella, P.
- Affiliations
- Universitat de Miguel Hernández d'Elx (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Fernández, Eduardo
- Venue
- Advanced Biosystems
- Publisher
- Wiley
- Published
- 2017-09-11
- Volume
- 2
- Issue
- 1
- ISSN
- 2366-7478 (ISSN-L)
- OpenAlex
- W2754908480
- Cited by
- 11
- References
- 190
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Biosystems (publishedVersion)
- Funders
- Spanish Government (MAT2015-69967-C3-1-R)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- intracortical microelectrodes, neural implants, biocompatibility, biomaterials, tissue encapsulation, long-term implantation, neural recording
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