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Cited by 9Alzheimer's disease research and treatmentsCell death mechanisms and regulationPancreatic and Hepatic Oncology Research

Inhibition of Pancreatic Cancer Cells by Different Amyloid Proteins Reveals an Inverse Relationship between Neurodegenerative Diseases and Cancer

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Tang, Yijing, Zhang, Dong, Robinson, Sarah, Zheng, Jie·2023·Advanced Biology
DOI 10.1002/adbi.202300070
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Abstract

Neurodegenerative diseases and cancers are considered to be two families of diseases caused by completely opposite cell‐death mechanisms: the former caused by premature cell death, with the latter due to the increased resistance to cell death. Growing epidemiologic evidence appear to suggest an inverse correlation between neurodegenerative diseases and cancers. However, pathological links, particularly from a protein‐cell interaction perspective, between these two families of diseases remains to be proven. Here, a fundamental study investigates the effects of three amyloid proteins of Aβ (associated with AD), hIAPP (associated with T2D), and hCT (associated with MTC) on pancreatic cancer (PANC‐1) cells. Collective results demonstrate a general inhibitory activity of all of three amyloid proteins on cancer cell proliferation, but inhibition efficiencies are strongly dependent on amyloid sequence (Aβ, hIAPP, hCT), concentration (IC25, IC50, IC75), and aggregation states (monomers, oligomers). Amyloid proteins exhibit two pathways against cancer cells: amyloid monomer‐induced ROS production to inhibit cell growth and amyloid oligomer‐induced membrane disruption to kill cells. Collectively, the results demonstrate a general inhibition function of amyloid proteins to induce cancer cell death by preventing cell proliferation, suppressing cell migration, promoting reactive oxygen species production, and disrupting cell membranes.

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Cited by

Sorted by citations

Authors
Tang, Y., Zhang, D., Robinson, S., & Zheng, J.
Affiliations
University of Akron (US)
Corresponding author
Zheng, Jie
ORCID
Venue
Advanced Biology
Publisher
Wiley
Published
2023-04-20
Volume
7
Issue
8
Pages
e2300070-e2300070
ISSN
2701-0198 (ISSN-L)
DOI
10.1002/adbi.202300070
OpenAlex
W4366465258
Cited by
9
References
2
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2023: 1
FWCI
1.59
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (2107619)
  • Division of Chemical, Bioengineering, Environmental, and Transport Systems (2107619, CBET-2107619)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Keywords
pancreatic cancer, amyloid proteins, human islet amyloid polypeptide, cancer cell proliferation inhibition, reactive oxygen species, membrane damage, amyloid oligomers, PANC-1 cells, cell migration
MeSH terms
Amyloid, Humans, Pancreatic Hormones, Pancreatic Neoplasms, Neurodegenerative Diseases, Amyloidogenic Proteins, Islet Amyloid Polypeptide

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