Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways

SEER Cancer Statistics Review, 1975-2003

Ries, L. A. G., Harkins, D., Krapcho, M. F., Mariotto, A. B., Miller, B., Feuer, E. J., Clegg, L. X., Eisner, M. P., Horner, M., Howlader, N., et al. (2006) · Digital Archive @ GSU · Cited by 11,404 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Cancer Statistics, 2007

Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., & Thun, M. J. (2007) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.57.1.43 · Cited by 7,439 · see citing works

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

Walter, P., & Ron, D. (2011) · Science · doi:10.1126/science.1209038 · Cited by 5,893 · see citing works

Otto Warburg's contributions to current concepts of cancer metabolism

Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427 · see citing works

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,653 · see citing works

Notch signalling: a simple pathway becomes complex

Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620 · see citing works

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

Tabas, I. A., & Ron, D. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-184 · Cited by 2,603 · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100 · see citing works

ER stress-induced cell death mechanisms

Sano, R., & Reed, J. C. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.028 · Cited by 1,988 · see citing works

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1× · see citing works

Essential role of mouse telomerase in highly proliferative organs

Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Energy metabolism in tumor cells

Moreno‐Sánchez, R., Rodríguez‐Enríquez, S., Marín‐Hernández, Á., & Saavedra, E. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05686.x · Cited by 1,086 · see citing works

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

Masters, C. L., Multhaup, G., Simms, G., Pottgiesser, J., Martins, R. N., & Beyreuther, K. T. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04000.x · Cited by 1,043 · see citing works

The impact of the unfolded protein response on human disease

Wang, S.-Y., & Kaufman, R. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201110131 · Cited by 960 · see citing works

A human peptidyl–prolyl isomerase essential for regulation of mitosis

Lu, K. P., Hanes, S. D., & Hunter, T. (1996) · Nature · doi:10.1038/380544a0 · Cited by 908 · see citing works

Notch signalling in solid tumours: a little bit of everything but not all the time

Ranganathan, P., Weaver, K. L., & Capobianco, A. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3035 · Cited by 818 · see citing works

Hydrogen peroxide as second messenger in lymphocyte activation

Reth, M. G. (2002) · Nature Immunology · doi:10.1038/ni1202-1129 · Cited by 777 · see citing works

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

Yaffe, M. B., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J., Xu, J., Kuang, J., Kirschner, M. W., Fischer, G. S., et al. (1997) · Science · doi:10.1126/science.278.5345.1957 · Cited by 770 · see citing works

THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

Rowinsky, E. K. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.353 · Cited by 724 · see citing works

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

Lu, P., Zhou, X. Z., Shen, M., & Lu, K. P. (1999) · Science · doi:10.1126/science.283.5406.1325 · Cited by 683 · see citing works

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

Lu, K. P., & Zhou, X. Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2261 · Cited by 682 · see citing works

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

Sigal, A., & Rotter, V. (2000) · PubMed · Cited by 669 · see citing works

Proteostasis impairment in protein-misfolding and -aggregation diseases

Hipp, M. S., Park, S.-H., & Hartl, F. U. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.05.003 · Cited by 656 · see citing works

Mechanisms of tau-induced neurodegeneration

Iqbal, K., Liu, F., Gong, C.-X., Alonso, A. D. C., & Grundke-Iqbal, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0486-3 · Cited by 628 · see citing works

DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

Yang, Y., Geldmacher, D., & Herrup, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02661.2001 · Cited by 607 · see citing works

Centrosome composition and microtubule anchoring mechanisms

Bornens, M. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(01)00290-3 · Cited by 570 · see citing works

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

Busser, J., Geldmacher, D. S., & Herrup, K. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02801.1998 · Cited by 543 · see citing works

The Warburg effect then and now: From cancer to inflammatory diseases

Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2013) · BioEssays · doi:10.1002/bies.201300084 · Cited by 538 · see citing works

Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1

Wulf, G. M., Ryo, A., Wulf, G. G., Lee, S. W., Niu, T., Petkova, V., & Lu, K. P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3459 · Cited by 529 · see citing works

Activation of the atf6, xbp1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the er stress pathway in hepatocarcinogenesis

Shuda, M., Kondoh, N., Imazeki, N., Tanaka, K., Okada, T., Mori, K., Hada, A., Arai, M., Wakatsuki, T., Matsubara, O., et al. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00029-1 · Cited by 520 · see citing works

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

Mandelkow, E.-M., Drewes, G., Biernat, J., Gustke, N., Van Lint, J., Vandenheede, J. R., & Mandelkow, E. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81496-9 · Cited by 515 · see citing works

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Pastorino, L., Sun, A., Lu, P.-J., Zhou, X. Z., Balastik, M., Finn, G., Wulf, G., Lim, J., Li, S.-H., Li, X., et al. (2006) · Nature · doi:10.1038/nature04543 · Cited by 487 · see citing works

Sirtuins, a promising target in slowing down the ageing process

Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works

MiR-34, SIRT1, and p53: The feedback loop

Yamakuchi, M., & Lowenstein, C. J. (2009) · Cell Cycle · doi:10.4161/cc.8.5.7753 · Cited by 468 · see citing works

Genetic signatures of exceptional longevity in humans

Sebastiani, P., Solovieff, N., DeWan, A. T., Walsh, K. M., Puca, A., Hartley, S. W., Melista, E., Andersen, S., Dworkis, D. A., Wilk, J. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029848 · Cited by 464 · see citing works

Incidence and Risk of Dementia: The Rotterdam study

Ott, A., Breteler, M. M. B., Harskamp, F. V., Stijnen, T., & Hofman, A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009489 · Cited by 455 · see citing works

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

Vincent, I. J., Jicha, G. A., Rosado, M., & Dickson, D. W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03588.1997 · Cited by 444 · see citing works

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

Liou, Y., Sun, A., Ryo, A., Zhou, X. Z., Yu, Z.-X., Huang, H.-K., Uchida, T., Bronson, R. T., Bing, G., Li, X., et al. (2003) · Nature · doi:10.1038/nature01832 · Cited by 436 · see citing works

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

Mańczak, M., Park, B. S., Jung, Y., & Reddy, P. H. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:2:147 · Cited by 432 · see citing works

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

Driver, J. A., Beiser, A., Au, R., Kreger, B. E., Splansky, G. L., Kurth, T., Kiel, D. P., Lu, K. P., Seshadri, S., & Wolf, P. A. (2012) · BMJ · doi:10.1136/bmj.e1442 · Cited by 425 · see citing works

Sirt1 modulates premature senescence-like phenotype in human endothelial cells

Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M., & Ouchi, Y. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.008 · Cited by 422 · see citing works

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

McShea, A., Harris, P. L. R., Webster, K. R., Wahl, A. F., & Smith, M. A. (1997) · Europe PMC (PubMed Central) · Cited by 422 · see citing works

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

Domenech, J. M. D., Vidal, S. J., Rodríguez-Bravo, V., Castillo-Martín, M., Quinn, S. A., Barrueco, R. R., Bonal, D. M., Charytonowicz, E., Gladoun, N., de la Iglesia-Vicente, J., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.07.016 · Cited by 416 · see citing works

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio, F., Volinia, S., Ronai, Z. A., Blandino, G., Schneider, C., & Sal, G. D. (2002) · Nature · doi:10.1038/nature01120 · Cited by 413 · see citing works

Two faces of p53: aging and tumor suppression

Rodier, F., Campisi, J., & Bhaumik, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm744 · Cited by 399 · see citing works

Mitotic mechanisms in Alzheimer's disease?

Vincent, I., Rosado, M., & Davies, P. (1996) · The Journal of cell biology · doi:10.1083/jcb.132.3.413 · Cited by 386 · see citing works

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G. M., Gu, L., Tang, X., Lu, K. P., & Xiao, Z. J. (2002) · Nature · doi:10.1038/nature01116 · Cited by 384 · see citing works

Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span

Andersen, S. L., Paola Sebastiani, B., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr223 · Cited by 382 · see citing works

Genetics of healthy aging and longevity

Brooks-Wilson, A. R. (2013) · Human Genetics · doi:10.1007/s00439-013-1342-z · Cited by 380 · see citing works

Prevalent Overexpression of Prolyl Isomerase Pin1 in Human Cancers

Bao, L., Kimzey, A. L., Sauter, G., Sowadski, J. M., Lu, K. P., & Wang, D.-G. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63731-5 · Cited by 378 · see citing works

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease

Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377 · see citing works

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

Erster, S. H., Mihara, M., Kim, R. H., Petrenko, O., & Moll, U. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6728-6741.2004 · Cited by 367 · see citing works

Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions

Fernandez, P. M., Tabbara, S. O., Jacobs, L. K., Manning, F. C. R., Tsangaris, T. N., Schwartz, A. M., Kennedy, K. A., & Patierno, S. R. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006332011207 · Cited by 338 · see citing works

Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P., Bronson, R. T., Fujimori, F., Uchida, T., Hunter, T. R., & Lu, K. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032404099 · Cited by 338 · see citing works

Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study

Feldman, H., Ferris, S. H., Winblad, B. G., Sfikas, N., Mancione, L., He, Y., Tekin, S., Burns, A. S., Cummings, J. L., del Ser, T., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70109-6 · Cited by 335 · see citing works

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

Liou, Y., Zhou, X. Z., & Lu, K. P. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.07.001 · Cited by 326 · see citing works

p53, Oxidative Stress, and Aging

Liu, D., & Xu, Y. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3644 · Cited by 315 · see citing works

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

de la Monte, S. M., Sohn, Y. K., & Wands, J. R. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00131-7 · Cited by 307 · see citing works

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

Ong, A. L. C., & Ramasamy, T. S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.02.004 · Cited by 301 · see citing works

Efficacy of donepezil in mild cognitive impairment

Salloway, S., Ferris, S. H., Kluger, A., Goldman, R. S., Griesing, T., Kumar, D., & Richardson, S. (2004) · Neurology · doi:10.1212/01.wnl.0000134664.80320.92 · Cited by 300 · see citing works

Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study

Musicco, M., Adorni, F., Di Santo, S., Prinelli, F., Pettenati, C., Caltagirone, C., Palmer, K., & Russo, A. (2013) · Neurology · doi:10.1212/wnl.0b013e31829c5ec1 · Cited by 295 · see citing works

Alzheimer disease, the two-hit hypothesis: An update

Zhu, X., Lee, H., Perry, G. L., & Smith, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.014 · Cited by 292 · see citing works

Cancer linked to Alzheimer disease but not vascular dementia

Roe, C. M., Fitzpatrick, A. L., Xiong, C., Sieh, W., Kuller, L. H., Miller, J. P., Williams, M. M., Kopan, R., Behrens, M. I., & Morris, J. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c91873 · Cited by 288 · see citing works

Mutant p53: an oncogenic transcription factor

Strano, S., Dell’Orso, S., Agostino, S. D., Fontemaggi, G., Sacchi, A., & Blandino, G. (2007) · Oncogene · doi:10.1038/sj.onc.1210296 · Cited by 270 · see citing works

Safety and efficacy of galantamine in subjects with mild cognitive impairment

Winblad, B. G., Gauthier, S. G., Scinto, L. F. M., Feldman, H., Wilcock, G. K., Truyen, L., Mayorga, A. J., Wang, D., Brashear, H. R., Nye, J. S., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000303815.69777.26 · Cited by 267 · see citing works

Cholinesterase in embryonic development.

Drews, U. (1975) · PubMed · Cited by 263 · see citing works

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

Nakamura, K., Greenwood, A., Binder, L. I., Bigio, E. H., Denial, S., Nicholson, L. K., Zhou, X. Z., & Lu, K. P. (2012) · Cell · doi:10.1016/j.cell.2012.02.016 · Cited by 255 · see citing works

PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells

Ryo, A., Liou, Y.-C., Wulf, G. M., Nakamura, M., Lee, S. W., & Lu, K. P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5281-5295.2002 · Cited by 254 · see citing works

Mitotic signaling by β‐amyloid causes neuronal death

Copani, A., Condorelli, F., CARUSO, A., Vancheri, C., Sala, A., Stella, A. M. G., Canonico, P. L., Nicoletti, F., & Sortino, M. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2225 · Cited by 246 · see citing works

Parkinson’s disease and cancer risk: a systematic review and meta-analysis

Bajaj, A., Driver, J. A., & Schernhammer, E. S. (2010) · Cancer Causes & Control · doi:10.1007/s10552-009-9497-6 · Cited by 244 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

Wulf, G. M., Finn, G., Suizu, F., & Lu, K. P. (2005) · Nature Cell Biology · doi:10.1038/ncb0505-435 · Cited by 238 · see citing works

Role of Pin1 in the Regulation of p53 Stability and p21 Transactivation, and Cell Cycle Checkpoints in Response to DNA Damage

Wulf, G. M., Liou, Y., Ryo, A., Lee, S. W., & Lu, K. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200538200 · Cited by 228 · see citing works

The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration

Giovanni, S. D., Knights, C. D., Rao, M., Yakovlev, A. G., Beers, J., Catania, J., Avantaggiati, M. L., & Faden, A. I. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601292 · Cited by 226 · see citing works

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

Nagy, Z., Esiri, M. M., & Smith, A. D. (1997) · Acta Neuropathologica · doi:10.1007/s004010050617 · Cited by 225 · see citing works

Alzheimer disease and cancer

Roe, C. M., Behrens, M. I., Xiong, C., Miller, J. P., & Morris, J. C. (2005) · Neurology · doi:10.1212/01.wnl.0000152889.94785.51 · Cited by 225 · see citing works

Cancer metabolism in space and time: Beyond the Warburg effect

Danhier, P., Bański, P., Payen, V. L., Grasso, D., Ippolito, L., Sonveaux, P., & Porporato, P. E. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.02.001 · Cited by 214 · see citing works

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

MacLachlan, T. K., Somasundaram, K., Sgagias, M. K., Shifman, Y., Muschel, R. J., Cowan, K. H., & El‐Deiry, W. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2777 · Cited by 212 · see citing works

Atypical cancer pattern in patients with Parkinson's disease

Olsen, J. H., Friis, S., Frederiksen, K., McLaughlin, J. K., Mellemkjær, L., & Møller, H. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602279 · Cited by 210 · see citing works

Variation in the human TP53 gene affects old age survival and cancer mortality

van Heemst, D., Mooijaart, S. P., Beekman, M., Schreuder, J., de Craen, A. J. M., Brandt, B. W., Slagboom, P. E., & Westendorp, R. G. J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.10.001 · Cited by 206 · see citing works

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Inestrosa, N. C., & Toledo, E. M. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-9 · Cited by 206 · see citing works

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

Ibáñez, K., Boullosa, C., Tabarés‐Seisdedos, R., Baudot, A., & Valencia, A. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004173 · Cited by 203 · see citing works

Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies

Catalá-López, F., Suárez‐Pinilla, M., Suárez‐Pinilla, P., Valderas, J. M., Gómez-Beneyto, M., Martı́nez, S., Balanzá‐Martínez, V., Climent, J., Valencia, A., McGrath, J. J., et al. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000356498 · Cited by 201 · see citing works

The Search for Longevity and Healthy Aging Genes: Insights From Epidemiological Studies and Samples of Long-Lived Individuals

Murabito, J. M., Yuan, R., & Lunetta, K. L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls089 · Cited by 200 · see citing works

Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

Wulf, G. M., Garg, P., Liou, Y., Iglehart, D. J., & Lu, K. P. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600323 · Cited by 199 · see citing works

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

Ding, Q., Huo, L., Yang, J.-Y., Xia, W., Wei, Y., Liao, Y., Chang, C.-J., Yang, Y., Lai, C., Lee, D., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0579 · Cited by 199 · see citing works

Cholinesterase in Embronic Development

Drews, U. (1975) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(75)80008-8 · Cited by 197 · see citing works

Clinical Phenotype of Families with Longevity

Atzmon, G., Schechter, C. B., Greiner, W., Davidson, D. E., Rennert, G., & Barzilai, N. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52068.x · Cited by 190 · see citing works

Epidemiology and Pathophysiology of Prostate Cancer in African-American Men

Powell, I. J. (2007) · The Journal of Urology · doi:10.1016/j.juro.2006.09.024 · Cited by 184 · see citing works

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

Lee, T. H., Chen, C.-H., Suizu, F., Huang, P., Schiene-Fischer, C., Daum, S., Zhang, Y. J., Goate, A., Chen, R.-H., Zhou, X. Z., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.005 · Cited by 183 · see citing works

Cancer and ageing: convergent and divergent mechanisms

Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2242 · Cited by 182 · see citing works

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

Gasparini, L., Racchi, M., Binetti, G. G., Trabucchi, M., Solerte, S. B., Alkon, D. L., Etcheberrigaray, R., Gibson, G. E., Blass, J. P., Paoletti, R., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.1.17 · Cited by 175 · see citing works

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

Hung, A. Y., Koo, E. H., Haass, C., & Selkoe, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9439 · Cited by 175 · see citing works

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

Rustighi, A., Tiberi, L., Soldano, A., Napoli, M., Nuciforo, P. G., Rosato, A., Kaplan, F. M., Capobianco, A. J., Pece, S., Fiore, P. P. D., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1822 · Cited by 170 · see citing works

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.026 · Cited by 165 · see citing works

The paradox of the unfolded protein response in cancer.

Vandewynckel, Y., Laukens, D., Geerts, A. M., Bogaerts, E., Paridaens, A., Verhelst, X., Janssens, S., Heindryckx, F., & Vlierberghe, H. V. (2013) · PubMed · Cited by 164 · see citing works

Redox signalling and transition metals in the control of the p53 pathway

Méplan, C., Richard, M., & Hainaut, P. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00297-x · Cited by 163 · see citing works

The non‐apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

Tedeschi, A., & Giovanni, S. D. (2009) · EMBO Reports · doi:10.1038/embor.2009.89 · Cited by 159 · see citing works

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

Salminen, A., Ojala, J., & Kaarniranta, K. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0597-y · Cited by 158 · see citing works

Minnesota multiphasic personality inventory-rated depression and the incidence of breast cancer

Hahn, R. C., & Petitti, D. B. (1988) · Cancer · doi:10.1002/1097-0142(19880215)61:4 · Cited by 157 · see citing works

Prevalence and Risks of Dementia in the Japanese Population: RERF's Adult Health Study Hiroshima Subjects

Yamada, M., Sasaki, H., Mimori, Y., Kasagi, F., Sudoh, S., Ikeda, J., Hosoda, Y., Nakamura, S., & Kodama, K. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb04577.x · Cited by 156 · see citing works

Prolyl‐isomerase Pin1 controls normal and cancer stem cells of the breast

Rustighi, A., Zannini, A., Tiberi, L., Sommaggio, R., Piazza, S., Sorrentino, G., Nuzzo, S., Tuscano, A., Eterno, V., Benvenuti, F., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302909 · Cited by 156 · see citing works

Telomerase, senescence and ageing

Shawi, M., & Autexier, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.007 · Cited by 156 · see citing works

Epigenetics of dementia: understanding the disease as a transformation rather than a state

Maloney, B., & Lahiri, D. K. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00065-x · Cited by 154 · see citing works

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

Beekman, M., Nederstigt, C., Suchiman, H. E. D., Kremer, D., van der Breggen, R., Lakenberg, N., Alemayehu, W. G., de Craen, A. J. M., Westendorp, R. G. J., Boomsma, D. I., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003540107 · Cited by 152 · see citing works

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

Mantovani, F., Tocco, F., Girardini, J. E., Smith, P., Gasco, M., Lü, X., Crook, T., & Sal, G. D. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1306 · Cited by 150 · see citing works

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

van Dyck, C. H., Nygaard, H. B., Chen, K., Donohue, M., Raman, R., Rissman, R. A., Brewer, J. B., Koeppe, R. A., Chow, T. W., Rafii, M. S., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2050 · Cited by 144 · see citing works

Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease

McShea, A., Wahl, A. F., & Smith, M. A. (1999) · Medical Hypotheses · doi:10.1054/mehy.1997.0680 · Cited by 140 · see citing works

A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration

Tedeschi, A., Nguyen, T. N., Puttagunta, R., Gaub, P., & Giovanni, S. D. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.175 · Cited by 139 · see citing works

Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death

Folch, J., Junyent, F., Verdaguer, E., Auladell, C., Pizarro, J. G., Beas‐Zárate, C., Pallàs, M., & Camins, A. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9277-4 · Cited by 138 · see citing works

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

Halliday, M., & Mallucci, G. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.034 · Cited by 125 · see citing works

Aging without Dementia is Achievable: Current Evidence from Epidemiological Research

Qiu, C., & Fratiglioni, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171037 · Cited by 125 · see citing works

Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging

Bergman, A., Atzmon, G., Ye, K. Q., MacCarthy, T., & Barzilai, N. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030170 · Cited by 117 · see citing works

Modulation of Gene Expression by Tumor-Derived p53 Mutants

Scian, M. J., Stagliano, K. E., Ellis, M. A., Hassan, S., Bowman, M., Miles, M. F., Deb, S. P., & Deb, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1568 · Cited by 117 · see citing works

Elevated levels of pro‐apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

Cenini, G., Sultana, R., Memo, M., & Butterfield, D. A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00163.x · Cited by 117 · see citing works

Cancer prevalence and mortality in centenarians: a systematic review

Pavlidis, N., Stanta, G., & Audisio, R. A. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2011.09.007 · Cited by 115 · see citing works

Association of cancer and Alzheimer's disease risk in a national cohort of veterans

Frain, L., Swanson, D., Cho, K., Gagnon, D., Lu, K. P., Betensky, R. A., & Driver, J. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.04.012 · Cited by 115 · see citing works

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

Lee, T. H., Tun-Kyi, A., Shi, R., Lim, J., Soohoo, C., Finn, G., Balaštík, M., Pastorino, L., Wulf, G. M., Zhou, X. Z., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1818 · Cited by 113 · see citing works

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Breaks In vivo

Rashid, S. T. A., Dellaire, G., Cuddihy, A. R., Jalali, F., Vaid, M., Coackley, C. L., Folkard, M., Xu, Y., Chen, B. P. C., Chen, D. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0729 · Cited by 107 · see citing works

Brain pathologies in extreme old age

Neltner, J. H., Abner, E. L., Jicha, G. A., Schmitt, F. A., Patel, E., Poon, L. W., Marla, G., Green, R. C., Davey, A., Johnson, M. A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.009 · Cited by 106 · see citing works

Cancer of the Oldest Old: What we Have Learned from Autopsy Studies

Stanta, G., Campagner, L., Cavallieri, F., & Giarelli, L. (1997) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30182-4 · Cited by 106 · see citing works

Post‐phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function

Zita, M. M., Marchionni, I., Bottos, E., Righi, M., Sal, G. D., Cherubini, E., & Zacchi, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601625 · Cited by 103 · see citing works

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

Kim, B. M., You, M.-H., Chen, C.-H., Lee, S., Hong, Y., Hong, Y., Kimchi, A., Zhou, X. Z., & Lee, T. H. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.216 · Cited by 98 · see citing works

Cell cycle-related protein expression in vascular dementia and Alzheimer's disease

Smith, M., Nagy, Z., & Esiri, M. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00509-1 · Cited by 97 · see citing works

p53 in neurodegenerative diseases and brain cancers

Checler, F., & da Costa, C. A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.11.009 · Cited by 97 · see citing works

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

Chen, C.-H., Li, W., Rukhsana Sultana, A., You, M., Kondo, A., Shahpasand, K., Kim, B. M., Luo, M.-L., Nechama, M., Lin, Y., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.027 · Cited by 97 · see citing works

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer

Sánchez-Valle, J., Tejero, H., Ibáñez, K., Portero, J. L., Krallinger, M., Al‐Shahrour, F., Tabarés‐Seisdedos, R., Baudot, A., & Valencia, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-04400-6 · Cited by 97 · see citing works

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest

Guillouf, C., Graña, X., Selvakumaran, M., Luca, A. D., Giordano, A., Hoffman‐Liebermann, B., & Liebermann, D. A. (1995) · Blood · doi:10.1182/blood.v85.10.2691.bloodjournal85102691 · Cited by 95 · see citing works

p53 at the crossroads between cancer and neurodegeneration

Lanni, C., Racchi, M., Memo, M., Govoni, S., & Uberti, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.034 · Cited by 95 · see citing works

Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis.

Lapidot-Lifson, Y., Prody, C. A., Ginzberg, D., Meytes, D., Zakut, H. V., & Soreq, H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4715 · Cited by 94 · see citing works

Phosphorylated Tau: Toxic, Protective, or None of the Above

Castellani, R. J., Nunomura, A., Lee, H., Perry, G. L., & Smith, M. A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14404 · Cited by 92 · see citing works

An inverse-Warburg effect and the origin of Alzheimer’s disease

Demetrius, L., & Simon, D. K. (2012) · Biogerontology · doi:10.1007/s10522-012-9403-6 · Cited by 90 · see citing works

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

Sorrentino, G., Mioni, M., Giorgi, C., Ruggeri, N., Pinton, P., Moll, U. M., Mantovani, F., & Sal, G. D. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.112 · Cited by 89 · see citing works

Endoplasmic reticulum quality control in cancer: Friend or foe

Kim, H., Bhattacharya, A., & Qi, L. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.02.003 · Cited by 87 · see citing works

Does Alzheimer’s Disease Protect against Cancers? A Nationwide Population-Based Study

Ou, S., Lee, Y.-J., Hu, Y., Liu, C., Chen, T., Fuh, J., & Wang, S. (2012) · Neuroepidemiology · doi:10.1159/000341411 · Cited by 86 · see citing works

Prolyl Isomerase Pin1 Promotes Amyloid Precursor Protein (APP) Turnover by Inhibiting Glycogen Synthase Kinase-3β (GSK3β) Activity

Ma, S. L., Pastorino, L., Zhou, X. Z., & Lu, K. P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.298596 · Cited by 85 · see citing works

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53

Salvioli, S., Capri, M., Bucci, L., Lanni, C., Racchi, M., Uberti, D. L., Memo, M., Mari, D., Govoni, S. M., & Franceschi, C. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0639-6 · Cited by 84 · see citing works

Maintenance of retinal stem cells byAbcg2is regulated by notch signaling

Bhattacharya, S., Das, A. V., Mallya, K. B., & Ahmad, I. (2007) · Journal of Cell Science · doi:10.1242/jcs.008417 · Cited by 83 · see citing works

Pin1 allows for differential Tau dephosphorylation in neuronal cells

Hamdane, M., Dourlen, P., Bretteville, A., Sambo, A., Ferreira, S., Ando, K., Kerdraon, O., Bégard, S., Geay, L., Lippens, G. M., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.03.006 · Cited by 82 · see citing works

Duplicating Dangerously

Doxsey, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00654-8 · Cited by 82 · see citing works

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function

Chen, C.-H., Chang, C., Lee, T. H., Luo, M., Huang, P., Liao, P.-H., Wei, S., Li, F., Chen, R., Zhou, X. Z., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4360 · Cited by 82 · see citing works

Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas.

Zakut, H. V., Ehrlich, G., Ayalon, A., Prody, C. A., Malinger, G., Seidman, S., Ginzberg, D., Kehlenbach, R. H., & Soreq, H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114791 · Cited by 81 · see citing works

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

Grison, A., Mantovani, F., Comel, A., Agostoni, E., Gustincich, S., Persichetti, F., & Sal, G. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106198108 · Cited by 79 · see citing works

In Vivo Synaptic Density Imaging with ¹¹ C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease

Toyonaga, T., Smith, L. M., Finnema, S. J., Gallezot, J.-D., Naganawa, M., Bini, J., Mulnix, T., Cai, Z., Ropchan, J., Huang, Y., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.223867 · Cited by 79 · see citing works

Alzheimer disease and cancer risk: a meta-analysis

Shi, H., Tang, B., Liu, Y.-W., Wang, X., & Chen, G. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1773-5 · Cited by 74 · see citing works

A cohort study of effectiveness of acetylcholinesterase inhibitors in Alzheimer’s disease

Raschetti, R., Maggini, M., Sorrentino, G. C., Martini, N., Caffari, B., & Vanacore, N. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0946-1 · Cited by 74 · see citing works

The Peptidyl-Isomerase Pin1 Regulates p27kip1 Expression through Inhibition of Forkhead Box O Tumor Suppressors

Brenkman, A. B., de Keizer, P. L. J., van den Broek, N. J. F., van der Groep, P., van Diest, P. J., van der Horst, A., de Vries-Smits, A. M. M., & Burgering, B. M. T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1059 · Cited by 73 · see citing works

Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function

Rangasamy, V., Mishra, R., Sondarva, G. V., Das, S., Lee, T. H., Bakowska, J. C., Tzivion, G., Malter, J. S., Rana, B., Lu, K. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200804109 · Cited by 72 · see citing works

Biological Hallmarks of Cancer in Alzheimer’s Disease

Nudelman, K. N. H., McDonald, B. C., Lahiri, D. K., & Saykin, A. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1591-5 · Cited by 72 · see citing works

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism?

da Costa, C. A., & Checler, F. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.020 · Cited by 71 · see citing works

A role for cholinesterases in tumorigenesis?

Soreq, H., Lapidot-Lifson, Y., & Zakut, H. V. (1991) · PubMed · Cited by 68 · see citing works

Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin

Nakamura, K., Kosugi, I., Lee, D. Y., Hafner, A. V., Sinclair, D. A., Ryo, A., & Lu, K. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05688-11 · Cited by 67 · see citing works

Competitive electrochemical immunosensor for the detection of unfolded p53 protein in blood as biomarker for Alzheimer’s disease

Amor-Gutiérrez, O., Costa‐Rama, E., Varas, N. A., Martínez-Rodríguez, C., Novelli, A., Fernández‐Sánchez, M. T., & Costa‐García, A. (2019) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.09.042 · Cited by 67 · see citing works

Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk

White, R. S., Lipton, R. B., Hall, C. B., & Steinerman, J. R. (2013) · Neurology · doi:10.1212/wnl.0b013e3182941990 · Cited by 66 · see citing works

Neuropathology and cognitive performance in self-reported cognitively healthy centenarians

Ganz, A. B., Beker, N., Hulsman, M., Sikkes, S. A. M., NBB, Scheltens, P., Smit, A. B., Rozemüller, A. J. M., Hoozemans, J. J. M., & Holstege, H. H. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0558-5 · Cited by 66 · see citing works

β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain

Buoso, E., Lanni, C., Schettini, G., Govoni, S. M., & Racchi, M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.05.002 · Cited by 66 · see citing works

Characterization of activities and forms of cholinesterases in human primary brain tumors

Razon, N., Soreq, H., Roth, E., Bartal, A., & Silman, I. (1984) · Experimental Neurology · doi:10.1016/0014-4886(84)90215-2 · Cited by 64 · see citing works

Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis

Szychowski, K. A., Wnuk, A., Rzemieniec, J., Kajta, M., Leszczyńska, T., & Wójtowicz, A. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1083-z · Cited by 64 · see citing works

Cancer in the oldest old

Andersen, S. L., Terry, D. F., Wilcox, M., Babineau, T. J., Malek, K. S., & Perls, T. T. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.019 · Cited by 63 · see citing works

Amyloid precursor protein in human breast cancer: An androgen‐induced gene associated with cell proliferation

Takagi, K., Ito, S., Miyazaki, T., Miki, Y., Shibahara, Y., Ishida, T., Watanabe, M., Inoue, S., Sasano, H., & Suzuki, T. (2013) · Cancer Science · doi:10.1111/cas.12239 · Cited by 59 · see citing works

Aberrancies in signal transduction and cell cycle related events in Alzheimer’s disease

Arendt, T., Holzer, M., Gärtner, U., & Brückner, M. K. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-7508-8_14 · Cited by 58 · see citing works

PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin

Cheng, C.-W., Chow, A. K.-M., Pang, R. W. C., Fok, E., Kwong, Y., & Tse, E. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.034 · Cited by 57 · see citing works

Mortality cancer risk in parkinsonian patients: A population-based study

Vanacore, N., Alegiani, S. S., Raschetti, R., & Meco, G. (1999) · Neurology · doi:10.1212/wnl.52.2.395 · Cited by 55 · see citing works

Association of cancer history with Alzheimer's disease onset and structural brain changes

Nudelman, K. N. H., Risacher, S. L., West, J. D., McDonald, B. C., Gao, S., Saykin, A. J., & Initiative, A. D. N. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00423 · Cited by 54 · see citing works

Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence

Hafsi, H., & Hainaut, P. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3771 · Cited by 53 · see citing works

Mortality cancer risk in parkinsonian patients: A population-based study

Riggs, J. E., Vanacore, N., Alegiani, S. S., Raschetti, R., & Meco, G. (1999) · Neurology · doi:10.1212/wnl.53.5.1158-a · Cited by 53 · see citing works

Conversion to dementia in mild cognitive impairment diagnosed with DSM ‐5 criteria and with Petersen's criteria

Marcos, G., Santabárbara, J., López‐Antón, R., De‐la‐Cámara, C., Gracia‐García, P., Lobo, E., Pírez, G., Menchón, J. M., Palomo, T., Stephan, B. C. M., et al. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12543 · Cited by 53 · see citing works

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism

Racchi, M., & Govoni, S. M. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01380-2 · Cited by 52 · see citing works

Correlates of response to acetylcholinesterase inhibitor therapy in Alzheimer’s disease

Lanctôt, K. L., Herrmann, N., & Loulou, M. (2003) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0302 · Cited by 52 · see citing works

Tumor Diagnosis Preceding Alzheimer's Disease Onset: Is There a Link Between Cancer and Alzheimer's Disease?

Realmuto, S., Cinturino, A., Arnao, V., Mazzola, M. A., Cupidi, C., Aridon, P., Ragonese, P., Savettieri, G., & D’Amelio, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120184 · Cited by 51 · see citing works

Cancer incidence in old age

Miyaishi, O., Ando, F., Matsuzawa, K., Kanawa, R., & Isobe, K. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00136-6 · Cited by 51 · see citing works

Comparison of the Effect of Mutant and Wild-Type p53 on Global Gene Expression

O’Farrell, T. J., Ghosh, P., Dobashi, N., Sasaki, C. Y., & Longo, D. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3639 · Cited by 48 · see citing works

Association of Cancer History with Alzheimer’s Disease Dementia and Neuropathology

Yarchoan, M. M., James, B. D., Shah, R. C., Arvanitakis, Z., Wilson, R. S., Schneider, J. A., Bennett, D. A., & Arnold, S. E. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160977 · Cited by 47 · see citing works

The inverse association of cancer and Alzheimer's: a bioenergetic mechanism

Demetrius, L., & Simon, D. K. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0006 · Cited by 46 · see citing works

Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors.

Gnatt, A. L., Prody, C. A., Zamir, R., Lieman‐Hurwitz, J., Zakut, H. V., & Soreq, H. (1990) · PubMed · Cited by 44 · see citing works

Alzheimer's Disease-Related Loss of Pin1 Function Influences the Intracellular Localization and the Processing of AβPP

Pastorino, L., Ma, S. L., Balaštík, M., Huang, P., Pandya, D., Nicholson, L. K., & Lu, K. P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111259 · Cited by 42 · see citing works

p53 Pro-Oxidant Activity in the Central Nervous System: Implication in Aging and Neurodegenerative Diseases

Chatoo, W., Abdouh, M., & Bernier, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3610 · Cited by 41 · see citing works

Inverse correlation between Alzheimer’s disease and cancer: implication for a strong impact of regenerative propensity on neurodegeneration?

Li, J., Liu, C., Hu, X., Cai, Y., Ma, C., Luo, X., & Yan, X. (2014) · BMC Neurology · doi:10.1186/s12883-014-0211-2 · Cited by 41 · see citing works

Copper Alters the Conformation and Transcriptional Activity of the Tumor Suppressor Protein p53 in Human Hep G2 Cells

Tassabehji, N. M., VanLandingham, J. W., & Levenson, C. W. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523001002 · Cited by 37 · see citing works

A double‐blind, placebo‐controlled trial of memantine in age‐associated memory impairment (memantine in AAMI)

Ferris, S. H., Schneider, L. S. S., Farmer, M. V., Kay, G. G., & Crook, T. H. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1711 · Cited by 36 · see citing works

Tau proteins expressions in advanced breast cancer and its significance in taxane-containing neoadjuvant chemotherapy

Li, Z., Xiong, Q., Tu, J., Gong, Y., Qiu, W., Zhang, H., Wei, W.-S., Hou, Y., & Cui, W.-Q. (2013) · Medical Oncology · doi:10.1007/s12032-013-0591-y · Cited by 34 · see citing works

Activation of sphingosine kinase mediates suppressive effect of interleukin‐6 on human multiple myeloma cell apoptosis

Li, Q., Wu, C.-T., Duan, H., Sun, H., Wang, H., Lu, Z., Zhang, Q., Liu, H., & Wang, L. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06711.x · Cited by 33 · see citing works

Alzheimer Disease and Cancer

Sherzai, A. Z., Parasram, M., Haider, J. M., & Sherzai, D. (2020) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000369 · Cited by 32 · see citing works

Glioblastoma and dementia may share a common cause

Lehrer, S. P. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.01.031 · Cited by 31 · see citing works

Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer’s Disease

Monacelli, F., Cea, M., Borghi, R., Odetti, P. R., & Nencioni, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160840 · Cited by 30 · see citing works

Unfolded p53 in Blood as a Predictive Signature Signature of the Transition from Mild Cognitive Impairment to Alzheimer's Disease

Lanni, C., Racchi, M., Stanga, S., Mazzini, G., Ranzenigo, A., Polotti, R., Memo, M., Govoni, S. M., & Uberti, D. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1347 · Cited by 30 · see citing works

Faster cognitive decline in elders without dementia and decreased risk of cancer mortality

Benito‐León, J., Romero, J. P., Louis, E. D., & Bermejo‐Pareja, F. (2014) · Neurology · doi:10.1212/wnl.0000000000000350 · Cited by 28 · see citing works

Zyxin is a novel target for beta‐amyloid peptide: characterization of its role in Alzheimer's pathogenesis

Lanni, C., Necchi, D., Pinto, A., Buoso, E., Buizza, L., Memo, M., Uberti, D. L., Govoni, S. M., & Racchi, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12154 · Cited by 25 · see citing works

Association between chemotherapy and cognitive impairments in a large cohort of patients with colorectal cancer

Du, X. L., Cai, Y., & Symanski, E. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1882 · Cited by 24 · see citing works

Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital

Imalda, K., Hasegawa, R., Kato, T., Futakuchi, M., Takahashi, S., Ogawa, K., Asamoto, M., Yamamoto, T., Suzuki, K., Inagaki, T., et al. (1997) · Pathology International · doi:10.1111/j.1440-1827.1997.tb04496.x · Cited by 24 · see citing works

Chapter 16: Promoter elements and alternative splicing in the human ACHE gene

Ben-Aziz, R., Sternfeld, M., & Soreq, H. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62392-4 · Cited by 23 · see citing works

Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?

Farshbaf, M. J., & Ghaedi, K. (2016) · BioMetals · doi:10.1007/s10534-016-9981-x · Cited by 22 · see citing works

Electrochemical detection of different p53 conformations by using nanostructured surfaces

Tonello, S., Stradolini, F., Abate, G., Uberti, D. L., Serpelloni, M., Carrara, S., & Sardini, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-53994-6 · Cited by 21 · see citing works

Mild Cognitive Impairment and Dementia Show Contrasting Associations with Risk of Cancer

van der Willik, K. D., Ruiter, R., Wolters, F. J., Ikram, M. K., Stricker, B. H. C., Hauptmann, M., Compter, A., Schagen, S. B., & Ikram, M. A. (2018) · Neuroepidemiology · doi:10.1159/000488892 · Cited by 20 · see citing works

AβPP Intracellular C-Terminal Domain Function is Related to its Degradation Processes

Buoso, E., Biundo, F., Lanni, C., Schettini, G., Govoni, S. M., & Racchi, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111961 · Cited by 17 · see citing works

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Herdy, J. R., Traxler, L., Agarwal, R. K., Karbacher, L., Schlachetzki, J. C. M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C. K., Mertens, J., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.11.010 · Cited by 208 · see citing works

FNDC5/Irisin: Physiology and Pathophysiology

Waseem, R., Shamsi, A., Mohammad, T., Hassan, M. I., Kazim, S. N., Chaudhary, A. A., Rudayni, H. A., Al-Zharani, M., Ahmad, F., & Islam, A. (2022) · Molecules · doi:10.3390/molecules27031118 · Cited by 180 · see citing works

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Liu, S., Liu, J., He, L., Liu, L., Cheng, B. H., Zhou, F., Cao, D., & He, Y. (2022) · Molecules · doi:10.3390/molecules27144400 · Cited by 145 · see citing works

Amyloid-beta and tau protein beyond Alzheimer’s disease

Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V. B., Nguyen, C. T. O., Finkelstein, D. I., You, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386406 · Cited by 121 · see citing works

Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients

Suzuki, M., Tezuka, K., Handa, T., Sato, R., Takeuchi, H., Takao, M., Tano, M., & Uchida, Y. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221111602 · Cited by 80 · see citing works

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

Zabłocka, A., Kazana, W., Sochocka, M., Stańczykiewicz, B., Janusz, M., Leszek, J., & Orzechowska, B. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02544-1 · Cited by 73 · see citing works

Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy

Pourmadadi, M., Abbasi, P., Eshaghi, M. M., Bakhshi, A., Manicum, A.-L. E., Rahdar, A., Pandey, S., Jadoun, S., & Diez-Pascual, A. M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103982 · Cited by 61 · see citing works

Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells

Zheng, F., Li, Y., Zhang, F., Sun, Y., Zheng, C., Luo, Z., Wang, Y.-L., Aschner, M., Zheng, H., Lin, L., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126378 · Cited by 51 · see citing works

Towards a Consensus on Alzheimer’s Disease Comorbidity?

Avitan, I., Halperin, Y., Saha, T., Bloch, N., Atrahimovich, D., Polis, B., Samson, A. O., & Braitbard, O. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194360 · Cited by 47 · see citing works

Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations

Tang, A. S., Oskotsky, T., Havaldar, S., Mantyh, W. G., Bicak, M., Solsberg, C. W., Woldemariam, S., Zeng, B., Hu, Z., Oskotsky, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28273-0 · Cited by 45 · see citing works

Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer.

Hang, Z.-C., Lei, T., Zeng, Z.-H., Cai, S.-L., Bi, W.-Y., & Du, H. (2021) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2021.112343 · Cited by 39 · see citing works

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R. (2022) · Cells · doi:10.3390/cells11121930 · Cited by 39 · see citing works

Role of neddylation in neurological development and diseases

He, X., Zhu, A., Feng, J., & Wang, X. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2112 · Cited by 39 · see citing works

The miR-25802/KLF4/NF-κB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer’s disease

Zhao, K., Liu, J., Sun, T., Zeng, L., Li, Z., Li, Z., & Liu, R. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.016 · Cited by 39 · see citing works

Investigating the association between cancer and dementia risk: a longitudinal cohort study

Zhang, D., Ou, Y., Liu, Y., Ma, Y., Tan, L., Feng, J., Cheng, W., & Yu, J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01090-9 · Cited by 36 · see citing works

Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies

Huang, J. B., Pham, V. T., Fu, S., Huang, G., Liu, Y., & Zheng, L. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01727-w · Cited by 38 · see citing works

Genomic loci influence patterns of structural covariance in the human brain

Wen, J., Nasrallah, I. M., Abdulkadir, A., Satterthwaite, T. D., Yang, Z., Erus, G., Robert‐Fitzgerald, T., Singh, A., Sotiras, A., Boquet-Pujadas, A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300842120 · Cited by 30 · see citing works

The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?

Ferri, E., Rossi, P. D., Geraci, A., Ciccone, S., Cesari, M., & Arosio, B. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.627931 · Cited by 33 · see citing works

Loss of microglial EED impairs synapse density, learning, and memory

Wang, Y.-Y., Deng, Y.-S., Dai, S.-K., Mi, T.-W., Li, R.-Y., Liu, P.-P., Liu, C., He, B.-D., He, X.-C., Du, H.-Z., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01576-w · Cited by 32 · see citing works

Proteostasis Deregulation in Neurodegeneration and Its Link with Stress Granules: Focus on the Scaffold and Ribosomal Protein RACK1

Masi, M., Attanzio, A., Racchi, M., Wolozin, B. L., Borella, S., Biundo, F., & Buoso, E. (2022) · Cells · doi:10.3390/cells11162590 · Cited by 29 · see citing works

The Roles of the Amyloid Beta Monomers in Physiological and Pathological Conditions

Schreiner, T. G., Schreiner, O. D., Adam, M., & Popescu, B. O. (2023) · Biomedicines · doi:10.3390/biomedicines11051411 · Cited by 30 · see citing works

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

Gan, Y., Deng, J., Hao, Q., Huang, Y., Han, T., Xu, J.-G., Zhao, M., Yao, L., Xu, Y., Xiong, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102705 · Cited by 29 · see citing works

Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment

Yao, Z., Dong, H., Zhu, J., Du, L., Luo, Y., Liu, Q., Liu, S., Lin, Y., Wang, L., Wang, S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.166306 · Cited by 29 · see citing works

Identification of peripheral blood immune infiltration signatures and construction of monocyte-associated signatures in ovarian cancer and Alzheimer's disease using single-cell sequencing

Zhao, S., Ye, B., Chi, H., Cheng, C., & Liu, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17454 · Cited by 26 · see citing works

The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration

Fagiani, F., Govoni, S. M., Racchi, M., & Lanni, C. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02179-8 · Cited by 26 · see citing works

WWOX and Its Binding Proteins in Neurodegeneration

Hsu, C.-Y., Lee, K., Sun, T.-Y., Sze, C., Huang, S., Hsu, L., & Chang, N. (2021) · Cells · doi:10.3390/cells10071781 · Cited by 25 · see citing works

Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer’s disease continuum

Wen, J., Yang, Z., Nasrallah, I. M., Cui, Y., Erus, G., Srinivasan, D., Abdulkadir, A., Mamourian, E., Skampardoni, I., Hwang, G., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03121-5 · Cited by 30 · see citing works

Transfer of Tumor-Bearing Mice Intestinal Flora Can Ameliorate Cognition in Alzheimer’s Disease Mice

Hang, Z., Cai, S., Lei, T., Zhang, X., Xiao, Z., Wang, D., Li, Y., Bi, W., Yang, Y., Deng, S., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215495 · Cited by 22 · see citing works

The Spectrum of Alzheimer-Type Pathology in Cognitively Normal Individuals

Walker, J. M., Dehkordi, S. K., Schaffert, J., Goette, W. F., White, C. L., Richardson, T. E., & Zare, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220898 · Cited by 24 · see citing works

The Labyrinthine Landscape of APP Processing: State of the Art and Possible Novel Soluble APP-Related Molecular Players in Traumatic Brain Injury and Neurodegeneration

Masi, M., Biundo, F., Fiou, A., Racchi, M., Pascale, A., & Buoso, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076639 · Cited by 20 · see citing works

Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2

Li, X., Tang, X., Zeng, J., Duan, L., Hou, Z., Li, L., Guo, Y., Chai, C., Liu, J., Wang, Y., et al. (2026) · Cell · doi:10.1016/j.cell.2025.12.020 · Cited by 21 · see citing works

Bioactivity evaluation of Polygonum minus and identification of synergistic phytochemicals with 5-fluorouracil for colon cancer treatment

Yang, Z., Yang, Z., Bakar, M. Z. A., & Deng, X. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.112917 · Cited by 21 · see citing works

Opposing Effects of ApoE2 and ApoE4 on Glycolytic Metabolism in Neuronal Aging Supports a Warburg Neuroprotective Cascade against Alzheimer’s Disease

Zhang, X., Wu, L., Swerdlow, R. H., & Zhao, L. (2023) · Cells · doi:10.3390/cells12030410 · Cited by 22 · see citing works

Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery

Ishii, T., Warabi, E., & Mann, G. E. (2023) · Antioxidants · doi:10.3390/antiox12020274 · Cited by 21 · see citing works

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice

Jeon, S. G., Lee, H., Park, H., Han, K., & Hoe, H. (2020) · Molecular Brain · doi:10.1186/s13041-020-00673-7 · Cited by 21 · see citing works

Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals

Fang, Y., Fritsche, L. G., Mukherjee, B., Sen, S., & Richmond‐Rakerd, L. S. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.004 · Cited by 19 · see citing works

Spatiotemporal insights of APP function

Dunot, J., Ribera, A., Pousinha, P. A., & Marie, H. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102754 · Cited by 21 · see citing works

Blood CDKN2A Gene Expression in Aging and Neurodegenerative Diseases

Mori, H., Funahashi, Y., Yoshino, Y., Kumon, H., Ozaki, Y., Yamazaki, K., Ochi, S., Tachibana, A., Yoshida, T., Shimizu, H., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210483 · Cited by 20 · see citing works

Prostate cancer treatment and the relationship of androgen deprivation therapy to cognitive function

Reiss, A. B., Saeedullah, U., Grossfeld, D. J., Glass, A. D., Pinkhasov, A., & Katz, A. E. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02727-1 · Cited by 20 · see citing works

Lower Incidence of Dementia Following Cancer Diagnoses: Evidence from a Large Cohort and Mendelian Randomization Study

Bassil, D. T., Zheng, B., Su, B., Kafetsouli, D., Udeh‐Momoh, C. T., Tzoulaki, I., Ahmadi‐Abhari, S., Muller, D. C., Ríboli, E., & Middleton, L. T. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.135 · Cited by 17 · see citing works

Inhibition of colorectal cancer in Alzheimer’s disease is mediated by gut microbiota via induction of inflammatory tolerance

Zhang, N., Zhang, R., Jiang, L., Gao, Z., Xia, W., Ma, X., Qin, Y., Zhang, D., Li, J., Tian, P., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314337121 · Cited by 17 · see citing works

Meta-analysis reveals an inverse relationship between Alzheimer’s disease and cancer

Gui, Z., Xu, M., Dong, Z., Abdelrahman, Z., & Wang, X. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115327 · Cited by 16 · see citing works

Comprehensive analysis of the expression and prognosis for APOE in malignancies: A pan-cancer analysis

Yu, S., Qian, L., & Ma, J. (2022) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2022.026141 · Cited by 15 · see citing works

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

Das, V., Miller, J. H., Goud, A. C., Annadurai, N., Sanctis, J. B. D., Hrubá, L., & Hajdúch, M. (2024) · Medicinal Research Reviews · doi:10.1002/med.22033 · Cited by 15 · see citing works

Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds

Annadurai, N., Malina, L., Salmona, M., Diomede, L., Bastone, A., Cagnotto, A., Romeo, M., Šrejber, M., Berka, K., Otyepka, M., et al. (2021) · FEBS Journal · doi:10.1111/febs.16270 · Cited by 14 · see citing works

Disease–disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes

Lin, Y., Yoo, J. M., Li, D., Heo, Y., Okumura, M., Won, H., Vendruscolo, M., Lim, M. H., & Lee, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00507-3 · Cited by 15 · see citing works

A common molecular and cellular pathway in developing Alzheimer and cancer

Ali, M., Wani, S. U. D., Dey, T., Sridhar, S. B., & QADRIE, Z. L. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101625 · Cited by 13 · see citing works

Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function

Cho, S. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042211 · Cited by 12 · see citing works

Cancer Cells Evade Stress-Induced Apoptosis by Promoting HSP70-Dependent Clearance of Stress Granules

Wang, A., Abulaiti, X., Zhang, H., Su, H., Liu, G., Gao, S., & Li, L. (2022) · Cancers · doi:10.3390/cancers14194671 · Cited by 11 · see citing works

Curious Dichotomies of Apolipoprotein E Function in Alzheimer’s Disease and Cancer—One Explanatory Mechanism of Inverse Disease Associations?

Perks, C. M., Barker, R. M., Alhadrami, M., Alkahtani, O., Gill, E., Grishaw, M., Harland, A. J., Henley, P., Li, H., O’Sullivan, E., et al. (2025) · Genes · doi:10.3390/genes16030331 · Cited by 11 · see citing works

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer’s DiseasePreprint

Wen, J., Yang, Z., Nasrallah, I. M., Cui, Y., Erus, G., Srinivasan, D., Abdulkadir, A., Mamourian, E., Skampardoni, I., Hwang, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.16.508329 · Cited by 12 · see citing works

Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Kassir, M. F., Lee, H. G., Oleinik, N. V., Wofford, W., Walton, C., Atilgan, F. C., Janneh, A. H., Chakraborty, P., Calisir, K., Percin, E., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4740 · Cited by 10 · see citing works

Causal association between colorectal cancer and Alzheimer’s disease: a bidirectional two-sample mendelian randomization study

Yuan, C., Liu, S., Yang, K., Xie, F., Li, Y., Guo, Y., Zhao, W., Zhang, J., & Cheng, Z. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1180905 · Cited by 10 · see citing works

Inhibition of Pancreatic Cancer Cells by Different Amyloid Proteins Reveals an Inverse Relationship between Neurodegenerative Diseases and Cancer

Tang, Y., Zhang, D., Robinson, S., & Zheng, J. (2023) · Advanced Biology · doi:10.1002/adbi.202300070 · Cited by 9 · see citing works

PIN1-mediated ROS production is involved in antagonism of N-acetyl-L-cysteine against arsenic-induced hepatotoxicity

Zhang, H., He, Z., Deng, P., Lu, M., Zhou, C., Yang, L., & Yu, Z. (2022) · Toxicology Research · doi:10.1093/toxres/tfac040 · Cited by 9 · see citing works

[Metabolic syndrome and magnesium].

Kumeda, Y., & Inaba, M. (2005) · PubMed · Cited by 9 · see citing works

Integrated Bioinformatic Analysis and Validation Identifies Immune Microenvironment-Related Potential Biomarkers in Alzheimer's Disease

Yang, F., Zhang, N., Ou, G., & Xu, S.-W. (2024) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2024.5 · Cited by 9 · see citing works

Factors associated with perceived cognitive function in breast cancer patients treated with chemotherapy: A multicenter cross-sectional study

Liu, Y., Liu, J., Shi, T.-Y., Bai, L.-X., Yang, A.-L., Li, R. Q., Su, Y.-L., Wang, P., Liu, J., & Zhang, L. (2024) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2024.102623 · Cited by 8 · see citing works

Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis

Greene, A. N., Solomon, M. B., & Vinnedge, L. M. P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1018180 · Cited by 7 · see citing works

Single‐cell transcriptomic analysis in clear cell renal cell carcinoma: Deciphering the role of APP within the tumour microenvironment

Guan, B., Li, M., Cui, D., Shen, C., Hao, Z., & Li, X. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18186 · Cited by 7 · see citing works

Involvement of transposable elements in Alzheimer’s disease pathogenesis

Mustafin, R., & Khusnutdinova, E. (2024) · Vavilovskii zhurnal genetiki i selektsii · doi:10.18699/vjgb-24-27 · Cited by 8 · see citing works

Recombination of repeat elements generates somatic complexity in human genomesPreprint

Pascarella, G., Hashimoto, K., Busch, A., Luginbühl, J., Parr, C., Hon, C.-C., Yip, W. H., Abe, K., Kratz, A., Bonetti, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.02.163816 · Cited by 8 · see citing works

Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia

Su, Z., Zhang, G., Li, X., & Zhang, H. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.07.002 · Cited by 7 · see citing works

Small RNA Sequencing in the Tg4–42 Mouse Model Suggests the Involvement of snoRNAs in the Etiology of Alzheimer’s Disease

Lio, C. T., Kacprowski, T., Klaedtke, M., Jensen, L. R., Bouter, Y., Bayer, T. A., & Kuss, A. W. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220110 · Cited by 7 · see citing works

Gene expression profiling and protein–protein interaction analysis reveals the dynamic role of MCM7 in Alzheimer's disorder and breast cancer

Sriram, N., Mukherjee, S., & Sah, M. K. (2022) · 3 Biotech · doi:10.1007/s13205-022-03207-1 · Cited by 7 · see citing works

Pain as a Protective Factor for Alzheimer Disease in Patients with Cancer

Xia, S., Yu, X., & Chen, G. (2022) · Cancers · doi:10.3390/cancers15010248 · Cited by 7 · see citing works

Towards a Clearer Causal Question Underlying the Association Between Cancer and Dementia

Rojas‐Saunero, L. P., van der Willik, K. D., Schagen, S. B., Ikram, M. A., & Swanson, S. A. (2024) · Epidemiology · doi:10.1097/ede.0000000000001712 · Cited by 7 · see citing works

Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma

Xu, X., Wang, J., Chen, T., Wang, S., Wang, F., He, J., Meng, X., & Shen, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1536142 · Cited by 6 · see citing works

Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)

Lei, S., Luo, M., & Wang, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13445 · Cited by 6 · see citing works

Potential role of TNFRSF12A in linking glioblastoma and alzheimer’s disease via shared tumour suppressor pathways

Liu, T., Pu, J., Theil, S., Liu, Y., Jiang, L., Liu, H., Maciaczyk, J., Schmidt‐Wolf, I. G. H., Walter, J., & Sharma, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-08000-7 · Cited by 6 · see citing works

Exome hits demystified: The next frontier

Ithal, D., Sukumaran, S. K., Bhattacharjee, D., Vemula, A., Nadella, R. K., Mahadevan, J., Sud, R., Viswanath, B., Purushottam, M., & Jain, S. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102640 · Cited by 6 · see citing works

Alzheimer’s risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer

Xia, W., Gao, Z., Jiang, X., Jiang, L., Qin, Y., Zhang, D., Tian, P., Wang, W., Zhang, Q., Zhang, R., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278774 · Cited by 6 · see citing works

Mosaic loss of the Y chromosome in human neurodegenerative and oncological diseases

Kuznetsova, I. L., Uralsky, L. I., Tyazhelova, T. V., Андреева, Т. В., & Рогаев, Е. И. (2023) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-23-61 · Cited by 6 · see citing works

Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease

Alexandre-Silva, V., & Cominetti, M. R. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111928 · Cited by 6 · see citing works

Fine Tuning of Cholinesterase and Glutathione-S-Transferase Activities by Organoruthenium(II) Complexes

Trobec, T., Sepčić, K., Žužek, M. C., Kladnik, J., Podjed, N., Páscoa, C. C., Turel, I., & Frangež, R. (2021) · Biomedicines · doi:10.3390/biomedicines9091243 · Cited by 6 · see citing works

Insights into Dysregulated Neurological Biomarkers in Cancer

Duranti, E., & Villa, C. (2024) · Cancers · doi:10.3390/cancers16152680 · Cited by 6 · see citing works

The inverse association between cancer history and incident cognitive impairment: Addressing attrition bias

Shardell, M. D., Rathbun, A. M., Gruber‐Baldini, A. L., Ryan, A. S., Guralnik, J. M., Kapogiannis, D., & Simonsick, E. M. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14268 · Cited by 5 · see citing works

Putative Molecular Mechanisms Underpinning the Inverse Roles of Mitochondrial Respiration and Heme Function in Lung Cancer and Alzheimer’s Disease

Afsar, A., & Li, Z. (2024) · Biology · doi:10.3390/biology13030185 · Cited by 5 · see citing works

Single-Cell Transcriptomic Profiling Reveals Regional Differences in the Prefrontal and Entorhinal Cortex of Alzheimer’s Disease Brain

Niu, R., Feng, W.-Q., Chen, L., & Bao, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104841 · Cited by 4 · see citing works

C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer

Liu, R., Zhao, M., Zhang, X., Wu, H., Ren, L., Lv, J., Liu, Z., Wang, Q., & Yao, Z. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116163 · Cited by 4 · see citing works

Novel Application of Ion Mobility Mass Spectrometry Reveals Complex Ganglioside Landscape in Diffuse Astrocytoma Peritumoral Regions

Ică, R., Sârbu, M., Biricioiu, M. R., Fabris, D., Vukelić, Ž., & Zamfir, A. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178433 · Cited by 4 · see citing works

Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies

Aung, K. Z., Zin, S. S., Wu, X., Myint, Z. W., Karanth, S. D., Estus, S., Norris, C. M., Nelson, P. T., Fardo, D. W., Abner, E. L., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107190 · Cited by 4 · see citing works

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Aleksandrova, Y. R., & Неганова, М. Е. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914766 · Cited by 4 · see citing works

Possibilities of Combinatorial Therapy: Insulin Dysregulation and the Growth Hormone Perspective on Neurodegeneration

Sengupta, P., & Mukhopadhyay, D. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97002 · Cited by 4 · see citing works

Upregulation of Pin1 contributes to alleviation of cognitive dysfunction in diabetic mice

Qiu, D., Liu, T., & Qianping, W. (2023) · Brain and Behavior · doi:10.1002/brb3.3336 · Cited by 4 · see citing works

Novel genomic loci influence patterns of structural covariance in the human brainPreprint

Wen, J., Nasrallah, I. M., Abdulkadir, A., Satterthwaite, T. D., Yang, Z., Erus, G., Robert‐Fitzgerald, T., Singh, A., Sotiras, A., Boquet-Pujadas, A., et al. (2022) · medRxiv · doi:10.1101/2022.07.20.22277727 · Cited by 4 · see citing works

Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer–Neurodegeneration Paradox

Rajarathinam, B., Nandan, D., Venugopal, P., Nair, A. M., John, S., Nair, B. G., & Aradhya, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27072989 · Cited by 3 · see citing works

Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation

Varathan, P., He, B., Xie, L., Nho, K. T., Saykin, A. J., & Yan, J. (2024) · BioData Mining · doi:10.1186/s13040-024-00400-1 · Cited by 3 · see citing works

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

Li, M., Wu, X., Jiang, L., Liu, M., Yanju, G., Li, X., Fan, T., Fan, Y., Wang, J., Wang, S., et al. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12527 · Cited by 2 · see citing works

Locus- and Gene-Level Insights into the Inverse Association Between Alzheimer’s Disease and Cancer

Debnath, D., Housini, M., Sariya, S., Phillips, N. R., Pathak, G. A., & Barber, R. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062900 · Cited by 2 · see citing works

Alzheimer's Disease and Cancer: Common Targets

Yang, X., Dai, J., Wu, C., & Liu, Z. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575263108231031132404 · Cited by 2 · see citing works

Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study

Huang, J., Deng, A., Bai, Y., Li, C., & Shang, H. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1391625 · Cited by 2 · see citing works

Association between gynecologic cancer and Alzheimer’s disease: a bidirectional mendelian randomization study

Cao, D., Zhang, S., Zhang, Y., Shao, M., Yang, Q., & Wang, P. (2024) · BMC Cancer · doi:10.1186/s12885-024-12787-5 · Cited by 1 · see citing works

Neuromorphic deviations associated with transcriptomic expression and specific cell type in Alzheimer’s disease

Peng, J., Tang, Q., Li, Y., Liu, L., Biswal, B., & Wang, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-90872-w · Cited by 1 · see citing works

Exploring the intersection of Alzheimer's disease and comorbidities: a review of the interplay between multiple chronic conditions

Khan, S., Imam, A., Singh, S., Ahmed, A., Hassan, M. I., Shahid, M., Athar, F., & Islam, A. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168190 · Cited by 1 · see citing works

Rethinking Alzheimer’s: novel miRNAs illuminate a disease beyond the brain

Novotný, J., Čarná, M., Dammer, E., Mao, Z., & Stokin, G. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03487-6 · Cited by 1 · see citing works

Risk of dementia following retinal vascular occlusions: A propensity-score matched cohort study using a global federated database

Hsieh, C., & Sung, S. (2026) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2026.108622 · Cited by 1 · see citing works

Emerging New Pathways in Malignant Neoplasms and Neurodegenerative Disorders: Perspectives for Therapeutics

Wrasidlo, W., & Masliah, E. (2026) · Cells · doi:10.3390/cells15131177 · Cited by 1 · see citing works

Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration

Chen, Y., Liu, T., Wen, K.-Y., Hsu, C.-Y., Sze, C., & Chang, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063507 · Cited by 1 · see citing works

Mapping the pathogenic nexus: Gene overlap and protein interaction networks in Alzheimer’s and breast cancer as a precursor to protein structure prediction and analysis

Chowdhury, M. R., Deepa, V. S., & Raja, V. K. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.11.007 · Cited by 2 · see citing works

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

Driver, J. A., Zhou, X. Z., & Lu, K. P. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.12.025 · Cited by 89 · see citing works

Pin1: A New Genetic Link between Alzheimers Disease, Cancer and Aging

Driver, J. A., & Lu, K. P. (2010) · Current Aging Science · doi:10.2174/1874609811003030158 · Cited by 92 · see citing works

A Common Biological Mechanism in Cancer and Alzheimers Disease?

Behrens, M. I., Lendon, C., & Roe, C. M. (2009) · Current Alzheimer Research · doi:10.2174/156720509788486608 · Cited by 185 · see citing works

A common molecular and cellular pathway in developing Alzheimer and cancer

Ali, M., Wani, S. U. D., Dey, T., Sridhar, S. B., & QADRIE, Z. L. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101625 · Cited by 13 · see citing works

Alzheimer Disease and Cancer

Sherzai, A. Z., Parasram, M., Haider, J. M., & Sherzai, D. (2020) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000369 · Cited by 32 · see citing works