CoChat
Sign Up
Cited by 9Liver Disease Diagnosis and Treatment3D Printing in Biomedical ResearchLiver physiology and pathology

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Open access
Youhanna, Sonia, Taebnia, Nayere, Liang, Yingxin, Cheng, Ningtao, Wang, Yi, Michel, Maurice, Lauschke, Volker M.·2025·Advanced Biology
DOI 10.1002/adbi.202500337PMC PMC12712776
Open this paper in CoChat — free accountOpen PDF

Abstract

Metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive form metabolic dysfunction‐associated steatohepatitis (MASH) are prevalent chronic liver diseases that are closely linked to metabolic syndrome, type 2 diabetes, and cardiovascular complications. Despite their rising incidence and growing socioeconomic burden, effective therapies remain limited. Traditional preclinical models often fail to replicate the complexity of human MASLD, particularly in capturing the interplay between patient‐specific predisposition, metabolic dysfunction, immune activation and progressive fibrosis. In this review, a comprehensive overview of emerging human‐based in vitro and ex vivo platforms is provided for use in MASLD research, including conventional 2D cultures, organoids, 3D spheroids, precision‐cut liver slices, microphysiological systems, and bioprinted constructs. Their utility is evaluated for modeling different stages of MASLD and MASH and their alignment with key disease hallmarks is discussed. Furthermore, the different models are assessed for their capability to model pathophysiologically relevant nutritional exposure, to emulate genetic risk factors, to reflect the complex hepatic cell repertoire and to conduct high‐throughput drug screenings. Recent successful applications of MASLD and MASH models are highlighted in drug discovery and development. Together, these insights aim to guide the refinement of human MASLD models to narrow the translational gap in MASH drug development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/adbi.202500337

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • For tasks related to disease progression (inflammation, fibrosis), as well as for rigorous studies of drug metabolism and toxicity, HepG2 should be used with caution, preferably as part of more complex systems (co-cultures, 3D platforms) or in combination with alternative models (HepaRG, primary hepatocytes).

    “For tasks related to disease progression (inflammation, fibrosis), as well as for rigorous studies of drug metabolism and toxicity, HepG2 should be used with caution, preferably as part of more complex systems (co-cultures, 3D platforms) or in combination with alternative models (HepaRG, primary hepatocytes) [158,159,160,161].”

    From The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease (2026) · cites this paper as [161]

    In “Model Systems for Hepatic Steatosis and Early MASLD” (page unavailable), the review says hepatoma cell lines have limited physiological relevance and lack the full complement of cytochrome P450 enzymes; it also describes HepaRG as more metabolically competent. In “Model Systems for MASH and Fibrosis” (page unavailable), it says co-cultures are required to capture the cell interactions underlying inflammation and fibrosis and that most MASH co-culture models use 3D tissues. These passages support caution with HepG2 and the use of more complex models, but do not specifically recommend combining HepG2 with HepaRG or primary hepatocytes for rigorous drug-metabolism and toxicity studies. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 159

  1. [1]G. Targher, C. D. Byrne, H. Tilg, Gut 2024, 73, 691. 38228377
  2. [2]V. Lekakis, G. V. Papatheodoridis, Eur. J. Intern. Med. 2024, 122, 3. 37940495
  3. [3]N. Stefan, H. Yki‐Järvinen, B. A. Neuschwander‐Tetri, Lancet Diabetes Endocrinol. 2024, 13, 134. 39681121
  4. [4]H. Hagström, Y. Shang, H. Hegmar, P. Nasr, Lancet Gastroenterol. Hepatol. 2024, 9, 944. 39243773
  5. [5]S. Sookoian, Y. Rotman, L. Valenti, Clin. Gastroenterol. Hepatol. 2024, 22, 2177. 39094912 PMC11512675
  6. [6]V. L. Chen, A. Kuppa, A. Oliveri, Y. Chen, P. Ponnandy, P. B. Patel, N. D. Palmer, E. K. Speliotes, J. Clin. Investig. 2025, 135, 186424. PMC11957700 40166930
  7. [7]O. Jamialahmadi, A. D. Vincentis, F. Tavaglione, F. Malvestiti, R. Li‐Gao, R. M. Mancina, M. Alvarez, K. Gelev, S. Maurotti, U. Vespasiani‐Gentilucci, F. R. Rosendaal, J. Kozlitina, P. Pajukanta, F. Pattou, L. Valenti, S. Romeo, Nat. Med. 2024, 30, 3614. 39653778 PMC11645285
  8. [8]J. Li, L. Yang, M. Xiao, N. Li, X. Huang, L. Ye, H. Zhang, Z. Liu, J. Li, Y. Liu, X. Liang, T. Li, J. Li, Y. Cao, Y. Pan, X. Lin, H. Dai, E. Dai, M. Li, Liver Int. 2025, 45, 16125.
  9. [9]A. A. Steixner‐Kumar, D. Santacruz, T. Geiger, W. Rust, D. Böttner, O. Krenkel, E. Bahrami, G. Okafo, T. F. E. Barth, M. Haenle, W. Kratzer, P. Schlingeloff, J. Schmidberger, H. Neubauer, A. Dick, M. Werner, E. Simon, Hepatol. Commun. 2025, 9, 0643. PMC12014121 40257301
  10. [10]K. Mladenić, M. Lenartić, S. Marinović, B. Polić, F. M. Wensveen, Eur. J. Immunol. 2024, 54, 2149641. 38314819
  11. [11]T. Kisseleva, S. Ganguly, R. Murad, A. Wang, D. A. Brenner, Gastroenterology 2025, 169, 797. 40120772 PMC12416914
  12. [12]Q. Dai, Q. Ain, N. Seth, M. Rooney, A. Zipprich, Dig. Liver Dis. 2025, 57, 493. 39904692
  13. [13]M. H. Le, Y. H. Yeo, X. Li, J. Li, B. Zou, Y. Wu, Q. Ye, D. Q. Huang, C. Zhao, J. Zhang, C. Liu, N. Chang, F. Xing, S. Yan, Z. H. Wan, N. S. Y. Tang, M. Mayumi, X. Liu, C. Liu, F. Rui, H. Yang, Y. Yang, R. Jin, R. H. X. Le, Y. Xu, D. M. Le, S. Barnett, C. D. Stave, R. Cheung, Q. Zhu, et al., Clin. Gastroenterol. Hepatol. 2022, 20, 2809. 34890795
  14. [14]V. Ajmera, S. Cepin, K. Tesfai, H. Hofflich, K. Cadman, S. Lopez, E. Madamba, R. Bettencourt, L. Richards, C. Behling, C. B. Sirlin, R. Loomba, J. Hepatol. 2023, 78, 471. 36410554 PMC9975077
  15. [15]F. Bril, P. Bolla, K. Huynh, S. Bobba, J. Endocr. Soc. 2025, 9, bvaf110. 40599337 PMC12210375
  16. [16]S. K. Bansal, M. B. Bansal, Aliment. Pharmacol. Ther. 2024, 59, S10. 38451123
  17. [17]Y. He, Y. Chen, S. Qian, S. van D Merwe, D. Dhar, D. A. Brenner, F. Tacke, Cell. Mol. Immunol. 2025, 22, 1159. 40494889 PMC12480724
  18. [18]M. Alexander, A. K. Loomis, J. van der Lei, T. Duarte‐Salles, D. Prieto‐Alhambra, D. Ansell, A. Pasqua, F. Lapi, P. Rijnbeek, M. Mosseveld, D. M. Waterworth, S. Kendrick, N. Sattar, W. Alazawi, BMC Med. 2019, 17, 95. 31104631 PMC6526616
  19. [19]Z. M. Younossi, M. Kalligeros, L. Henry, Clin. Mol. Hepatol. 2024, 31, S32. 39159948 PMC11925440
  20. [20]P. Le, M. Tatar, S. Dasarathy, N. Alkhouri, W. H. Herman, G. B. Taksler, A. Deshpande, W. Ye, O. A. Adekunle, A. McCullough, M. B. Rothberg, JAMA Netw. Open 2025, 8, 2454707. PMC11742522 39821400
  21. [21]Z. M. Younossi, D. Blissett, R. Blissett, L. Henry, M. Stepanova, Y. Younossi, A. Racila, S. Hunt, R. Beckerman, Hepatology 2016, 64, 1577. 27543837
  22. [22]C. Wallace, I. Gamkrelidze, C. Estes, H. Razavi, A. J. Sanyal, J. Hepatol. 2025, 83, 21. 39832655
  23. [23]S. A. Harrison, P. Bedossa, C. D. Guy, J. M. Schattenberg, R. Loomba, R. Taub, D. Labriola, S. E. Moussa, G. W. Neff, M. E. Rinella, Q. M. Anstee, M. F. Abdelmalek, Z. Younossi, S. J. Baum, S. Francque, M. R. Charlton, P. N. Newsome, N. Lanthier, I. Schiefke, A. Mangia, J. M. Pericàs, R. Patil, A. J. Sanyal, M. Noureddin, M. B. Bansal, N. Alkhouri, L. Castera, M. Rudraraju, V. Ratziu, M.‐N. Investigators, N. Engl. J. Med. 2024, 390, 497. 38324483
  24. [24]J. Arun, M. D. Sanyal, N. Philip, M. B. Newsome, M. D. Iris Kliers, M. T. Long, A. M. G. Cali, E. Bugianesi, M. E. Rinella, M. Roden, V. Ratziu, N. Engl. J. Med. 2025, 392, 2089.40305708
  25. [25]A. M. Kemas, S. Youhanna, V. M. Lauschke, Expert Rev. Precis. Med. Drug Dev. 2022, 7, 39.
  26. [26]M. Noureddin, Hepatology 2024, 10.1097/HEP.0000000000000860. · DOI
  27. [27]M. Vacca, I. Kamzolas, L. M. Harder, F. Oakley, C. Trautwein, M. Hatting, T. Ross, B. Bernardo, A. Oldenburger, S. T. Hjuler, I. Ksiazek, D. Lindén, D. Schuppan, S. Rodriguez‐Cuenca, M. M. Tonini, T. R. Castañeda, A. Kannt, C. M. P. Rodrigues, S. Cockell, O. Govaere, A. K. Daly, M. Allison, K. Honnens de Lichtenberg, Y. O. Kim, A. Lindblom, S. Oldham, A.‐C. Andréasson, F. Schlerman, J. Marioneaux, et al., Nat. Metab. 2024, 6, 1178. 38867022 PMC11199145
  28. [28]S. N. Hart, Y. Li, K. Nakamoto, E. Subileau, D. Steen, X. Zhong, Drug Metab. Dispos. 2010, 38, 988. 20228232 PMC2879958
  29. [29]R. L. C. Sison‐Young, D. Mitsa, R. E. Jenkins, D. Mottram, E. Alexandre, L. Richert, H. Aerts, R. J. Weaver, R. P. Jones, E. Johann, P. G. Hewitt, M. Ingelman‐Sundberg, C. E. P. Goldring, N. R. Kitteringham, B. K. Park, Toxicol. Sci. 2015, 147, 412. 26160117 PMC4583060
  30. [30]C. C. Bell, V. M. Lauschke, S. U. Vorrink, H. Palmgren, R. Duffin, T. B. Andersson, M. Ingelman‐Sundberg, Drug Metab. Dispos. 2017, 45, 419. 28137721 PMC5363699
  31. [31]R. L. Sison‐Young, V. M. Lauschke, E. Johann, E. Alexandre, S. Antherieu, H. Aerts, H. H. J. Gerets, G. Labbe, D. Hoët, M. Dorau, C. A. Schofield, C. A. Lovatt, J. C. Holder, S. H. Stahl, L. Richert, N. R. Kitteringham, R. P. Jones, M. Elmasry, R. J. Weaver, P. G. Hewitt, M. Ingelman‐Sundberg, C. E. Goldring, B. K. Park, Arch. Toxicol. 2017, 91, 1385. 27344343 PMC5316403
  32. [32]F. Bonanini, M. Singh, H. Yang, D. Kurek, A. C. Harms, A. Mardinoglu, T. Hankemeier, Exp. Cell Res. 2024, 437, 114008. 38499143
  33. [33]E. Luce, A. Messina, J. Duclos‐Vallée, A. Dubart‐Kupperschmitt, Hepatology 2021, 74, 1101. 33420753 PMC8457237
  34. [34]N. Graffmann, B. Scherer, J. Adjaye, Stem Cell Res. 2022, 61, 102763. 35395623
  35. [35]S. G. Tilson, C. M. Morell, A. Lenaerts, S. B. Park, Z. Hu, B. Jenkins, A. Koulman, T. J. Liang, L. Vallier, Hepatology 2021, 74, 2998. 34288010 PMC11497257
  36. [36]D. Hendriks, J. F. Brouwers, K. Hamer, M. H. Geurts, L. Luciana, S. Massalini, C. López‐Iglesias, P. J. Peters, M. J. Rodríguez‐Colman, S. C. de, S. Lopes, B. Artegiani, H. Clevers, Nat. Biotechnol. 2023, 41, 1567. 36823355 PMC10635827
  37. [37]N. Salomonis, P. J. Dexheimer, L. Omberg, R. Schroll, S. Bush, J. Huo, L. Schriml, S. H. Sui, M. Keddache, C. Mayhew, S. K. Shanmukhappa, J. Wells, K. Daily, S. Hubler, Y. Wang, E. Zambidis, A. Margolin, W. Hide, A. K. Hatzopoulos, P. Malik, J. A. Cancelas, B. J. Aronow, C. Lutzko, Stem Cell Rep. 2016, 7, 110. PMC4944587 27293150
  38. [38]R. E. Schwartz, H. E. Fleming, S. R. Khetani, S. N. Bhatia, Biotechnol. Adv. 2014, 32, 504. 24440487 PMC4043206
  39. [39]M. Baxter, S. Withey, S. Harrison, C.‐P. Segeritz, F. Zhang, R. Atkinson‐Dell, C. Rowe, D. T. Gerrard, R. Sison‐Young, R. Jenkins, J. Henry, A. A. Berry, L. Mohamet, M. Best, S. W. Fenwick, H. Malik, N. R. Kitteringham, C. E. Goldring, K. P. Hanley, L. Vallier, N. A. Hanley, J. Hepatol. 2015, 62, 581. 25457200 PMC4334496
  40. [40]A. I. Ardisasmita, I. F. Schene, I. P. Joore, G. Kok, D. Hendriks, B. Artegiani, M. Mokry, E. E. S. Nieuwenhuis, S. A. Fuchs, Commun. Biol. 2022, 5, 1094. 36241695 PMC9568534
  41. [41]Y. Liu, J.‐Y. Sheng, C.‐F. Yang, J. Ding, Y.‐S. Chan, Clin. Mol. Hepatol. 2023, 29, 643. 36880210 PMC10366802
  42. [42]S. Liu, C. Cheng, L. Zhu, T. Zhao, Z. Wang, X. Yi, F. Yan, X. Wang, C. Li, T. Cui, B. Yang, Stem Cell Res. Ther. 2024, 15, 244. 39113154 PMC11304926
  43. [43]A. C. de l'Hortet, K. Takeishi, J. Guzman‐Lepe, K. Morita, A. Achreja, B. Popovic, Y. Wang, K. Handa, A. Mittal, N. Meurs, Z. Zhu, F. Weinberg, M. Salomon, I. J. Fox, C.‐X. Deng, D. Nagrath, A. Soto‐Gutierrez, Cell Metab. 2019, 30, 385. 31390551 PMC6691905
  44. [44]M. N. B. Ramli, Y. S. Lim, C. T. Koe, D. Demircioglu, W. Tng, K. A. U. Gonzales, C. P. Tan, I. Szczerbinska, H. Liang, E. L. Soe, Z. Lu, C. Ariyachet, K. M. Yu, S. H. Koh, L. P. Yaw, N. H. B. Jumat, J. S. Y. Lim, G. Wright, A. Shabbir, Y. Y. Dan, H.‐H. Ng, Y.‐S. Chan, Gastroenterology 2020, 159, 1471. 32553762
  45. [45]S. McCarron, B. Bathon, D. M. Conlon, D. Abbey, D. J. Rader, K. Gawronski, C. D. Brown, K. M. Olthoff, A. Shaked, T. D. Raabe, Hepatology 2021, 74, 1825. 33901295 PMC12928191
  46. [46]Y. Goswami, A. Baghel, G. Sharma, P. K. Sharma, S. Biswas, R. Yadav, P. K. Garg, R. T. Shalimar, J. Clin. Exp. Hepatol. 2025, 15, 102463. 39872219 PMC11761825
  47. [47]S. P. Harrison, R. Siller, Y. Tanaka, M. E. Chollet, M. E. de la Morena‐Barrio, Y. Xiang, B. Patterson, E. Andersen, C. Bravo‐Pérez, H. Kempf, K. S. Åsrud, O. Lunov, A. Dejneka, M.‐C. Mowinckel, B. Stavik, P. M. Sandset, E. Melum, S. Baumgarten, F. Bonanini, D. Kurek, S. Mathapati, R. Almaas, K. Sharma, S. R. Wilson, F. S. Skottvoll, I. C. Boger, I. L. Bogen, T. A. Nyman, J. J. Wu, A. Bezrouk, et al., Exp. Mol. Med. 2023, 55, 2005. 37653039 PMC10545717
  48. [48]M. Ölander, C. Wegler, I. Flörkemeier, A. Treyer, N. Handin, J. M. Pedersen, A. Vildhede, A. Mateus, E. L. LeCluyse, J. Urdzik, P. Artursson, J. Cell. Physiol. 2021, 236, 5885. 33452735
  49. [49]C. Terry, A. Dhawan, R. R. Mitry, S. C. Lehec, R. D. Hughes, Liver Transplant. 2010, 16, 229. 20104500
  50. [50]M. Ingelman‐Sundberg, V. M. Lauschke, Basic Clin. Pharmacol. Toxicol. 2022, 130, 5. 33872466
  51. [51]K. Zhang, L. Zhang, W. Liu, X. Ma, J. Cen, Z. Sun, C. Wang, S. Feng, Z. Zhang, L. Yue, L. Sun, Z. Zhu, X. Chen, A. Feng, J. Wu, Z. Jiang, P. Li, X. Cheng, D. Gao, L. Peng, L. Hui, Cell Stem Cell 2018, 23, 806. 30416071
  52. [52]G.‐B. Fu, W.‐J. Huang, M. Zeng, X. Zhou, H.‐P. Wu, C.‐C. Liu, H. Wu, J. Weng, H.‐D. Zhang, Y.‐C. Cai, C. Ashton, M. Ding, D. Tang, B.‐H. Zhang, Y. Gao, W.‐F. Yu, B. Zhai, Z.‐Y. He, H.‐Y. Wang, H.‐X. Yan, Cell Res. 2019, 29, 8. 30361550 PMC6318298
  53. [53]C. Unzu, E. Planet, N. Brandenberg, F. Fusil, M. Cassano, J. Perez‐Vargas, M. Friedli, F. Cosset, M. P. Lutolf, B. E. Wildhaber, D. Trono, Hepatology 2019, 69, 2214. 30549291 PMC6519263
  54. [54]C. C. Bell, D. F. G. Hendriks, S. M. L. Moro, E. Ellis, J. Walsh, A. Renblom, L. F. Puigvert, A. C. A. Dankers, F. Jacobs, J. Snoeys, R. L. Sison‐Young, R. E. Jenkins, Å. Nordling, S. Mkrtchian, B. K. Park, N. R. Kitteringham, C. E. P. Goldring, V. M. Lauschke, M. Ingelman‐Sundberg, Sci. Rep. 2016, 6, 25187. 27143246 PMC4855186
  55. [55]S. U. Vorrink, S. Ullah, S. Schmidt, J. Nandania, V. Velagapudi, O. Beck, M. Ingelman‐Sundberg, V. M. Lauschke, FASEB J. 2017, 31, 2696. 28264975 PMC5434660
  56. [56]S. Messner, L. Fredriksson, V. M. Lauschke, K. Roessger, C. Escher, M. Bober, J. M. Kelm, M. Ingelman‐Sundberg, W. Moritz, Appl. In Vitro. Toxicol. 2018, 4, 1. PMC7500040 32953943
  57. [57]C. Morgantini, J. Jager, X. Li, L. Levi, V. Azzimato, A. Sulen, E. Barreby, C. Xu, M. Tencerova, E. Näslund, C. Kumar, F. Verdeguer, S. Straniero, K. Hultenby, N. K. Björkström, E. Ellis, M. Rydén, C. Kutter, T. Hurrell, V. M. Lauschke, J. Boucher, A. Tomčala, G. Krejčová, A. Bajgar, M. Aouadi, Nat. Metab. 2019, 1, 445. 32694874
  58. [58]T. Hurrell, V. Kastrinou‐Lampou, A. Fardellas, D. F. G. Hendriks, Å. Nordling, I. Johansson, A. Baze, C. Parmentier, L. Richert, M. Ingelman‐Sundberg, Cells 2020, 9, 964. 32295224 PMC7227007
  59. [59]S. Ströbel, R. Kostadinova, K. Fiaschetti‐Egli, J. Rupp, M. Bieri, A. Pawlowska, D. Busler, T. Hofstetter, K. Sanchez, S. Grepper, E. Thoma, Sci. Rep. 2021, 11, 22765. 34815444 PMC8611054
  60. [60]S. R. Trampuž, S. van Riet, Å. Nordling, M. Ingelman‐Sundberg, Cells 2023, 12, 302. 36672237 PMC9857203
  61. [61]S. van Riet, A. Julien, A. Atanasov, Å. Nordling, M. Ingelman‐Sundberg, Hepatol. Commun. 2024, 8, 0374. PMC10871795 38358377
  62. [62]M. Kozyra, I. Johansson, Å. Nordling, S. Ullah, V. M. Lauschke, M. Ingelman‐Sundberg, Sci. Rep. 2018, 8, 14297. 30250238 PMC6155201
  63. [63]R. M. Mancina, K. Sasidharan, A. Lindblom, Y. Wei, E. Ciociola, O. Jamialahmadi, P. Pingitore, A.‐C. Andréasson, G. Pellegrini, G. Baselli, V. Männistö, J. Pihlajamäki, V. Kärjä, S. Grimaudo, I. Marini, M. Maggioni, B. Becattini, F. Tavaglione, C. Dix, M. Castaldo, S. Klein, M. Perelis, F. Pattou, D. Thuillier, V. Raverdy, P. Dongiovanni, A. L. Fracanzani, F. Stickel, J. Hampe, S. Buch, et al., Nat. Metab. 2022, 4, 60. 35102341 PMC8803605
  64. [64]S. Youhanna, A. M. Kemas, S. C. Wright, Y. Zhong, B. Klumpp, K. Klein, A. Motso, M. Michel, N. Ziegler, M. Shang, P. Sabatier, A. Kannt, H. Sheng, N. Oliva‐Vilarnau, F. A. Büttner, B. Seashore‐Ludlow, J. Schreiner, M. Windbergs, M. Cornillet, N. K. Björkström, A. J. Hülsmeier, T. Hornemann, J. V. Olsen, Y. Wang, R. Gramignoli, M. Sundström, V. M. Lauschke, Adv. Sci. 2025, 12, 2407572. PMC11744578 39605182
  65. [65]A. M. Kemas, S. Youhanna, R. Zandi Shafagh, V. M. Lauschke, FASEB J. 2021, 35, 21305. PMC12266331 33566368
  66. [66]Y. Toba, S. Deguchi, N. Mimura, A. Sakamoto, K. Harada, K. Hirata, K. Takayama, H. Mizuguchi, PLoS One 2020, 15, 0229654. PMC7046223 32106262
  67. [67]N. Handin, E. Mickols, M. Ölander, J. Rudfeldt, K. Blom, F. Nyberg, W. Senkowski, J. Urdzik, V. Maturi, M. Fryknäs, P. Artursson, iScience 2021, 24, 103235. 34746700 PMC8551077
  68. [68]M. Haag, S. Winter, A. M. Kemas, J. Tevini, A. Feldman, S. K. Eder, T. K. Felder, C. Datz, B. Paulweber, G. Liebisch, O. Burk, V. M. Lauschke, E. Aigner, M. Schwab, JCI Insight 2025, 10, 180943. PMC12016937 40100312
  69. [69]G. Carpino, M. D. Ben, D. Pastori, R. Carnevale, F. Baratta, D. Overi, H. Francis, V. Cardinale, P. Onori, S. Safarikia, V. Cammisotto, D. Alvaro, G. Svegliati‐Baroni, F. Angelico, E. Gaudio, F. Violi, Hepatology 2020, 72, 470. 31808577
  70. [70]M. W. Toepke, D. J. Beebe, Lab Chip 2006, 6, 1484. 17203151
  71. [71]K. Ren, J. Zhou, H. Wu, Acc. Chem. Res. 2013, 46, 2396. 24245999
  72. [72]A. M. Kemas, R. Zandi Shafagh, N. Taebnia, M. Michel, L. Preiss, U. Hofmann, V. M. Lauschke, Adv. Healthcare Mater. 2024, 13, 2303561. PMC11469150 38053301
  73. [73]T. Fukazawa, Y. Yamazaki, Y. Miyamoto, J. Pharmacol. Toxicol. 2010, 61, 329. 20064623
  74. [74]A. W. Auner, K. M. Tasneem, D. A. Markov, L. J. McCawley, M. S. Hutson, Lab Chip 2019, 19, 864. 30720811 PMC6512955
  75. [75]C. Doueiry, C. S. Kappler, C. Martinez‐Morant, S. A. Duncan, Int. J. Mol. Sci. 2024, 25, 7277. 39000384 PMC11242544
  76. [76]N. Oliva‐Vilarnau, C. M. Beusch, P. Sabatier, E. Sakaraki, A. Tjaden, L. Graetz, F. A. Büttner, D. Dorotea, M. Nguyen, F. Bergqvist, Y. Sundström, S. Müller, R. A. Zubarev, G. Schulte, C. Tredup, R. Gramignoli, U. J. F. Tietge, V. M. Lauschke, Hepatology 2024, 79, 1337. 37870288 PMC11095891
  77. [77]T. Shinozawa, M. Kimura, Y. Cai, N. Saiki, Y. Yoneyama, R. Ouchi, H. Koike, M. Maezawa, R.‐R. Zhang, A. Dunn, A. Ferguson, S. Togo, K. Lewis, W. L. Thompson, A. Asai, T. Takebe, Gastroenterology 2021, 160, 831. 33039464 PMC7878295
  78. [78]C. J. Zhang, S. R. Meyer, M. J. O'Meara, S. Huang, M. M. Capeling, D. Ferrer‐Torres, C. J. Childs, J. R. Spence, R. J. Fontana, J. Z. Sexton, J. Hepatol. 2023, 78, 998. 36738840 PMC11268729
  79. [79]P. D. Stefano, E. Bianchi, G. Dubini, Biomicrofluidics 2022, 16, 031501. 35646223 PMC9142169
  80. [80]A. Capes‐Davis, G. Theodosopoulos, I. Atkin, H. G. Drexler, A. Kohara, R. A. F. MacLeod, J. R. Masters, Y. Nakamura, Y. A. Reid, R. R. Reddel, R. I. Freshney, Int. J. Cancer 2010, 127, 1. 20143388
  81. [81]M. J. G. Lechón, M. T. Donato, A. Martínez‐Romero, N. Jiménez, J. V. Castell, J.‐E. O'Connor, Chem.‐Biol. Interact. 2007, 165, 106. 17188672
  82. [82]W. Cui, S. L. Chen, K.‐Q. Hu, Am. J. Transl. Res. 2009, 2, 95. PMC2826826 20182586
  83. [83]Y. Teng, Z. Zhao, F. Tasnim, X. Huang, H. Yu, Biomaterials 2021, 275, 120904. 34119888
  84. [84]M. Pérez‐Carreras, P. D. Hoyo, M. A. Martín, J. C. Rubio, A. Martín, G. Castellano, F. Colina, J. Arenas, J. A. Solis‐Herruzo, Hepatology 2003, 38, 999. 14512887
  85. [85]I. Garcia‐Ruiz, P. Solis‐Munoz, D. Fernandez‐Moreira, T. Munoz‐Yague, J. A. Solis‐Herruzo, Dis. Models Mech. 2015, 8, 183. PMC4314783 25540128
  86. [86]T. W. Jung, H. C. Hong, H.‐J. Hwang, H. J. Yoo, S. H. Baik, K. M. Choi, Mol. Cell. Endocrinol. 2015, 417, 131. 26419929
  87. [87]H. H. J. Gerets, K. Tilmant, B. Gerin, H. Chanteux, B. O. Depelchin, S. Dhalluin, F. A. Atienzar, Cell Biol. Toxicol. 2012, 28, 69. 22258563 PMC3303072
  88. [88]G. Tascher, A. Burban, S. Camus, M. Plumel, S. Chanon, R. L. Guevel, V. Shevchenko, A. V. Dorsselaer, E. Lefai, C. Guguen‐Guillouzo, F. Bertile, Cells 2019, 8, 192. 30795634 PMC6406872
  89. [89]T. E. Maseko, M. Elkalaf, E. Peterová, H. Lotková, P. Staňková, J. Melek, J. Dušek, P. Žádníková, D. Čížková, A. Bezrouk, P. Pávek, Z. Červinková, O. Kučera, Int. J. Mol. Med. 2023, 53, 18. PMC10781417 38186319
  90. [90]N. Graffmann, S. Ring, M.‐A. Kawala, W. Wruck, A. Ncube, H.‐I. Trompeter, J. Adjaye, Stem Cells Dev. 2016, 25, 1119. 27308945 PMC4971413
  91. [91]M. Xia, M. Varmazyad, I. Pla‐Palacín, D. C. Gavlock, R. DeBiasio, G. LaRocca, C. Reese, R. M. Florentino, L. A. P. Faccioli, J. A. Brown, L. A. Vernetti, M. Schurdak, A. M. Stern, A. Gough, J. Behari, A. Soto‐Gutierrez, D. L. Taylor, M. T. Miedel, Front. Cell Dev. Biol. 2024, 12, 1423936. 39324073 PMC11422722
  92. [92]Y. Wang, N. Kory, S. BasuRay, J. C. Cohen, H. H. Hobbs, Hepatology 2019, 69, 2427. 30802989 PMC6563103
  93. [93]Y. Wang, S. Hong, H. Hudson, N. Kory, L. N. Kinch, J. Kozlitina, J. C. Cohen, H. H. Hobbs, J. Hepatol. 2025, 82, 871. 39550037 PMC12164368
  94. [94]D. Lindén, G. Tesz, R. Loomba, Liver Int. 2025, 45, 16186. PMC11907219 39605307
  95. [95]S. Joshi‐Barve, S. S. Barve, K. Amancherla, L. Gobejishvili, D. Hill, M. Cave, P. Hote, C. J. McClain, Hepatology 2007, 46, 823. 17680645
  96. [96]H. Wobser, C. Dorn, T. S. Weiss, T. Amann, C. Bollheimer, R. Büttner, J. Schölmerich, C. Hellerbrand, Cell Res. 2009, 19, 996. 19546889
  97. [97]M. D. Davidson, K. R. Ballinger, S. R. Khetani, Sci. Rep. 2016, 6, 28178. 27312339 PMC4911593
  98. [98]I. S. Piras, G. S. Gerhard, J. K. DiStefano, Cell. Physiol. Biochem. 2020, 54, 1068. 33095528 PMC8265013
  99. [99]V. M. Lauschke, S. U. Vorrink, S. M. L. Moro, F. Rezayee, Å. Nordling, D. F. G. Hendriks, C. C. Bell, R. Sison‐Young, B. K. Park, C. E. Goldring, E. Ellis, I. Johansson, S. Mkrtchian, T. B. Andersson, M. Ingelman‐Sundberg, Hepatology 2016, 64, 1743. 27532775
  100. [100]Y. Kwon, P. Gottmann, S. Wang, J. Tissink, K. Motzler, R. Sekar, W. Albrecht, C. Cadenas, J. G. Hengstler, A. Schürmann, A. Zeigerer, J. Hepatol. 2025, 82, 18. 38977136
  101. [101]S. Prill, A. Caddeo, G. Baselli, O. Jamialahmadi, P. Dongiovanni, R. Rametta, K. P. Kanebratt, A. Pujia, P. Pingitore, R. M. Mancina, D. Lindén, C. Whatling, A. Janefeldt, M. Kozyra, M. Ingelman‐Sundberg, L. Valenti, T. B. Andersson, S. Romeo, Sci. Rep. 2019, 9, 686. 31406127 PMC6690969
  102. [102]L. Rabiu, P. Zhang, L. O. Afolabi, M. A. Saliu, S. M. Dabai, R. B. Suleiman, K. I. Gidado, M. A. Ige, A. Ibrahim, G. Zhang, X. Wan, J. Gastroenterol. 2024, 59, 1053. 39400718
  103. [103]C. Ma, S. Wang, B. Dong, Y. Tian, Hepatology 2025, 10, 10.1097/HEP.0000000000001371. 40324062 · DOI
  104. [104]Q. He, W. He, H. Dong, Y. Guo, G. Yuan, X. Shi, D. Wang, F. Lu, Cell Commun. Signal. 2024, 22, 346. 38943171 PMC11214243
  105. [105]J. Boeckmans, A. Natale, M. Rombaut, K. Buyl, B. Cami, V. D. Boe, A. Heymans, V. Rogiers, J. D. Kock, T. Vanhaecke, R. M. Rodrigues, Cell Biol. Toxicol. 2021, 37, 293. 32613381
  106. [106]T. Kostrzewski, S. Snow, A. L. Battle, S. Peel, Z. Ahmad, J. Basak, M. Surakala, A. Bornot, J. Lindgren, M. Ryaboshapkina, M. Clausen, D. Lindén, C. Maass, L. M. Young, A. Corrigan, L. Ewart, D. Hughes, Commun. Biol. 2021, 4, 1080. 34526653 PMC8443589
  107. [107]M. D. Davidson, D. A. Kukla, S. R. Khetani, Integr. Biol. 2017, 9, 662. 28702667
  108. [108]R. Ouchi, S. Togo, M. Kimura, T. Shinozawa, M. Koido, H. Koike, W. Thompson, R. A. Karns, C. N. Mayhew, P. S. McGrath, H. A. McCauley, R.‐R. Zhang, K. Lewis, S. Hakozaki, A. Ferguson, N. Saiki, Y. Yoneyama, I. Takeuchi, Y. Mabuchi, C. Akazawa, H. Y. Yoshikawa, J. M. Wells, T. Takebe, Cell Metab. 2019, 30, 374. 31155493 PMC6687537
  109. [109]M. Kimura, T. Iguchi, K. Iwasawa, A. Dunn, W. L. Thompson, Y. Yoneyama, P. Chaturvedi, A. M. Zorn, M. Wintzinger, M. Quattrocelli, M. Watanabe‐Chailland, G. Zhu, M. Fujimoto, M. Kumbaji, A. Kodaka, Y. Gindin, C. Chung, R. P. Myers, G. M. Subramanian, V. Hwa, T. Takebe, Cell 2022, 185, 4216. 36240780 PMC9617783
  110. [110]X. Wu, D. Jiang, Y. Wang, X. Li, C. Liu, Y. Chen, W. Sun, R. He, Y. Yang, X. Gu, C. Jiang, Q. Ding, Hepatol. Commun. 2024, 8, 0585. PMC11608672 39621053
  111. [111]F. Segovia‐Miranda, H. Morales‐Navarrete, M. Kücken, V. Moser, S. Seifert, U. Repnik, F. Rost, M. Brosch, A. Hendricks, S. Hinz, C. Röcken, D. Lütjohann, Y. Kalaidzidis, C. Schafmayer, L. Brusch, J. Hampe, M. Zerial, Nat. Med. 2019, 25, 1885. 31792455 PMC6899159
  112. [112]R. Kostadinova, F. Boess, D. Applegate, L. Suter, T. Weiser, T. Singer, B. Naughton, A. Roth, Toxicol. Appl. Pharmacol. 2013, 268, 1. 23352505
  113. [113]Y. B. Kang, J. Eo, S. Mert, M. L. Yarmush, O. B. Usta, Sci. Rep. 2018, 8, 8951. 29895900 PMC5997652
  114. [114]B. Bulutoglu, C. Rey‐Bedón, Y. B. A. Kang, S. Mert, M. L. Yarmush, O. B. Usta, Lab Chip 2019, 19, 3022. 31465069 PMC6736752
  115. [115]M. F. Wesseler, N. Taebnia, S. Harrison, S. Youhanna, L. C. Preiss, A. M. Kemas, A. Vegvari, J. Mokry, G. J. Sullivan, V. M. Lauschke, N. B. Larsen, Acta Biomater. 2023, 171, 336. 37734628
  116. [116]T. Messelmani, A. L. Goff, F. Soncin, F. Gilard, Z. Souguir, N. Maubon, B. Gakière, C. Legallais, E. Leclerc, R. Jellali, Toxicology 2023, 492, 153550. 37209942
  117. [117]E. Wang, M. J. Andrade, Q. Smith, Biomicrofluidics 2023, 17, 064108. 38155919 PMC10754629
  118. [118]S. Lasli, H. Kim, K. Lee, C. E. Suurmond, M. Goudie, P. Bandaru, W. Sun, S. Zhang, N. Zhang, S. Ahadian, M. R. Dokmeci, J. Lee, A. Khademhosseini, Adv. Biosyst. 2019, 3, 1900104. PMC7473489 32648699
  119. [119]K. Du, S. Li, C. Li, P. Li, C. Miao, T. Luo, B. Qiu, W. Ding, Acta Biomater. 2021, 134, 228. 34265474
  120. [120]Y. Wang, H. Wang, P. Deng, T. Tao, H. Liu, S. Wu, W. Chen, J. Qin, ACS Biomater. Sci. Eng. 2020, 6, 5734. 33320545
  121. [121]T. Kostrzewski, T. Cornforth, S. A. Snow, L. Ouro‐Gnao, C. Rowe, E. M. Large, D. J. Hughes, World J. Gastroenterol. 2017, 23, 204. 28127194 PMC5236500
  122. [122]T. Kostrzewski, P. Maraver, L. Ouro‐Gnao, A. Levi, S. Snow, A. Miedzik, K. Rombouts, D. Hughes, Hepatol. Commun. 2020, 4, 77. 31909357 PMC6939502
  123. [123]M. S. Freag, B. Namgung, M. E. R. Fernandez, E. Gherardi, S. Sengupta, H. L. Jang, Hepatol. Commun. 2021, 5, 217. 33553970 PMC7850303
  124. [124]V. L. Slaughter, J. W. Rumsey, R. Boone, D. Malik, Y. Cai, N. N. Sriram, C. J. Long, C. W. McAleer, S. Lambert, M. L. Shuler, J. J. Hickman, Sci. Rep. 2021, 11, 13159. 34162924 PMC8222323
  125. [125]L. Qi, M. Groeger, A. Sharma, I. Goswami, E. Chen, F. Zhong, A. Ram, K. Healy, E. C. Hsiao, H. Willenbring, A. Stahl, Nat. Commun. 2024, 15, 7991. 39266553 PMC11393072
  126. [126]D. Bavli, S. Prill, E. Ezra, G. Levy, M. Cohen, M. Vinken, J. Vanfleteren, M. Jaeger, Y. Nahmias, Proc. Natl. Acad. Sci. USA 2016, 113, E2231. 27044092 PMC4843487
  127. [127]J. Kim, Y. Han, B. G. Jeon, M. S. Nam, S. Kwon, Y. J. Heo, M. Park, Talanta 2023, 260, 124592. 37172436
  128. [128]A. T. Young, K. R. Rivera, P. D. Erb, M. A. Daniele, ACS Sens. 2019, 4, 1454. 30964652 PMC6876853
  129. [129]L. Mou, K. Mandal, M. M. Mecwan, A. L. Hernandez, S. Maity, S. Sharma, R. D. Herculano, S. Kawakita, V. Jucaud, M. R. Dokmeci, A. Khademhosseini, Lab Chip 2022, 22, 3801. 36074812 PMC9635816
  130. [130]E. Palma, E. J. Doornebal, S. Chokshi, Hepatol. Int. 2019, 13, 51. 30515676 PMC6513823
  131. [131]L. Dewyse, H. Reynaert, L. A. van Grunsven, Int. J. Mol. Sci. 2021, 22, 7137. 34281187 PMC8267882
  132. [132]E. L. Shepherd, S. Karim, P. N. Newsome, P. F. Lalor, World J. Hepatol. 2020, 12, 931. 33312420 PMC7701969
  133. [133]M. Mabire, P. Hegde, A. Hammoutene, J. Wan, C. Caër, R. A. Sayegh, M. Cadoux, M. Allaire, E. Weiss, T. Thibault‐Sogorb, O. Lantz, M. Goodhardt, V. Paradis, P. de la Grange, H. Gilgenkrantz, S. Lotersztajn, Nat. Commun. 2023, 14, 1830. 37005415 PMC10067815
  134. [134]D. Bhattacharya, C. Becker, B. Readhead, N. Goossens, J. Novik, M. I. Fiel, L. P. Cousens, B. Magnusson, A. Backmark, R. Hicks, J. T. Dudley, S. L. Friedman, Sci. Rep. 2021, 11, 20827. 34675338 PMC8531016
  135. [135]G. Guagliano, C. Volpini, L. Sardelli, F. B. Vangosa, L. Visai, P. Petrini, Adv. Healthcare Mater. 2024, 13, 2303349. 38323754
  136. [136]V. Joshi, D. Carter, A. E. Chen, K. Murphy, J. W. Higgins, M. Gurel, D. C. Fuentes, S. B. Rosenthal, K. M. Fisch, T. Kisseleva, D. A. Brenner, PLoS One 2024, 19, 0312615. PMC11684678 39775546
  137. [137]P. K. Tan, T. Ostertag, S. B. Rosenthal, D. Chilin‐Fuentes, H. Aidnik, S. Linker, K. Murphy, J. N. Miner, D. A. Brenner, Am. J. Pathol. 2024, 194, 353. 38158078 PMC10913759
  138. [138]N. R. Powell, T. Liang, J. Ipe, S. Cao, T. C. Skaar, Z. Desta, H.‐R. Qian, P. J. Ebert, Y. Chen, M. K. Thomas, N. Chalasani, Nat. Commun. 2023, 14, 1474. 36927865 PMC10020163
  139. [139]Y. Zhao, J.‐Z. Li, Y.‐G. Liu, Y.‐J. Zhu, Y. Zhang, W.‐W. Zheng, L. Ma, J. Li, C.‐Y. Wang, World J. Hepatol. 2025, 17, 101741. 40027577 PMC11866136
  140. [140]X. Wu, D. Jiang, Y. Yang, S. Li, Q. Ding, Cell Regen 2023, 12, 6. 36864321 PMC9981852
  141. [141]C. I. Wells, H. Al‐Ali, D. M. Andrews, C. R. M. Asquith, A. D. Axtman, I. Dikic, D. Ebner, P. Ettmayer, C. Fischer, M. Frederiksen, R. E. Futrell, N. S. Gray, S. B. Hatch, S. Knapp, U. Lücking, M. Michaelides, C. E. Mills, S. Müller, D. Owen, A. Picado, K. S. Saikatendu, M. Schröder, A. Stolz, M. Tellechea, B. J. Turunen, S. Vilar, J. Wang, W. J. Zuercher, T. M. Willson, D. H. Drewry, Int. J. Mol. Sci. 2021, 22, 566.33429995
  142. [142]W. Chen, B. Chang, L. Li, L. Chan, Hepatology 2010, 52, 1134. 20648554 PMC2932863
  143. [143]J. Armisen, M. Rauschecker, J. Sarv, M. Liljeblad, L. Wernevik, M. Niazi, J. Knöchel, O. Eklund, T. Sandell, J. Sherwood, L. Bergenholm, S. Hallén, S. Wang, P. Kamble, M. Bhat, I. Maxvall, Y. Wang, R. G. Lee, S. Bhanot, S. Guo, S. Romeo, E. Lawitz, O. Fjellström, D. Lindén, J. E. Blau, R. Loomba, J. Hepatol. 2025, 83, 31. 39798707
  144. [144]V. Ratziu, Y. Yilmaz, D. Lazas, S. L. Friedman, C. Lackner, C. Behling, O. W. Cummings, L. Chen, M. Petitjean, Y. Gilgun‐Sherki, T. Gorfine, S. Kadosh, E. Eyal, A. J. Sanyal, Hepatology 2025, 81, 932. 38916482 PMC12186543
  145. [145]G. Gentric, V. Maillet, V. Paradis, D. Couton, A. L'Hermitte, G. Panasyuk, B. Fromenty, S. Celton‐Morizur, C. Desdouets, J. Clin. Investig. 2015, 125, 981. 25621497 PMC4362240
  146. [146]M. Michel, C. Benítez‐Buelga, P. A. Calvo, B. M. F. Hanna, O. Mortusewicz, G. Masuyer, J. Davies, O. Wallner, K. Sanjiv, J. J. Albers, S. Castañeda‐Zegarra, A.‐S. Jemth, T. Visnes, A. Sastre‐Perona, A. N. Danda, E. J. Homan, K. Marimuthu, Z. Zhenjun, C. N. Chi, A. Sarno, E. Wiita, C. von Nicolai, A. J. Komor, V. Rajagopal, S. Müller, E. C. Hank, M. Varga, E. R. Scaletti, M. Pandey, S. Karsten, et al., Science 2022, 376, 1471. 35737787
  147. [147]C. Benitéz‐Buelga, T. Helleday, M. Michel, Clin. Transl. Med. 2022, 12, 1035. PMC9423131 36037066
  148. [148]M. Kehler, K. Zhou, A. M. Kemas, A. del Prado, E. S. Hutchinson, E. H. Nairn, M. Varga, Y. Plattner, Y. Zhong, O. Purewal‐Sidhu, J. Haslam, E. Wiita, H. Gildie, K. Singerova, Z. Szaruga, I. Almlöf, F. M. Hormann, K. Liu, O. Wallner, F. Ortis, E. J. Homan, O. Gileadi, S. G. Rudd, P. Stenmark, M. de Vega, T. Helleday, N. D. D'Arcy‐Evans, V. M. Lauschke, M. Michel, Chemistry 2025, 31, 202500382. PMC12160960 40294343
  149. [149]P.‐J. H. Zushin, S. Mukherjee, J. C. Wu, J. Clin. Investig. 2023, 133, 175824. PMC10617761 37909337
  150. [150]S. A. Carratt, C. L. Z. de Zafra, E. Oziolor, P. Rana, N. R. Vansell, R. Mangipudy, V. S. Vaidya, Toxicol. Sci. 2024, 203, 28. 39298459
  151. [151]X. Wu, C. Yuan, J. Pan, Y. Zhou, X. Pan, J. Kang, L. Ren, L. Gong, Y. Li, Sci. Rep. 2024, 14, 16364. 39013959 PMC11252365
  152. [152]L. Cano, L. Desquilles, G. Ghukasyan, G. Angenard, C. Landreau, A. Corlu, B. Clément, B. Turlin, E. L. Ferrec, C. Aninat, J. Massart, O. Musso, JHEP Rep. 2024, 6, 100936. 38074511 PMC10698276
  153. [153]S. Ganji, N. Hoa, J. Kamanna, V. S. Kamanna, M. L. Kashyap, Am. J. Transl. Res. 2021, 14, 4006. PMC9274597 35836902
  154. [154]N. Hasui, K. Sakaguchi, T. Ogawa, Y. Sakamoto, T. Shimizu, Sci. Rep. 2022, 12, 5341. 35351975 PMC8964766
  155. [155]P. Pingitore, K. Sasidharan, M. Ekstrand, S. Prill, D. Lindén, S. Romeo, Int. J. Mol. Sci. 2019, 20, 1629. 30986904 PMC6480107
  156. [156]G. R. Romualdo, T. C. D. Silva, M. F. de, A. Landi, J. Á. Morais, L. F. Barbisan, M. Vinken, C. P. Oliveira, B. Cogliati, Environ. Toxicol. 2021, 36, 168. 32918399
  157. [157]A. Kermanizadeh, J. Valli, K. Sanchez, S. Hutter, A. Pawlowska, G. Whyte, W. Moritz, V. Stone, Arch. Toxicol. 2022, 96, 287. 34668024 PMC8748349
  158. [158]C.‐A. E. Suurmond, S. Lasli, F. W. van den Dolder, A. Ung, H.‐J. Kim, P. Bandaru, K. Lee, H.‐J. Cho, S. Ahadian, N. Ashammakhi, M. R. Dokmeci, J. Lee, A. Khademhosseini, Adv. Healthcare Mater. 2019, 8, 1901379. 31746151
  159. [159]J. Bronsard, C. Savary, J. Massart, R. Viel, L. Moutaux, D. Catheline, V. Rioux, B. Clement, A. Corlu, B. Fromenty, P. J. Ferron, Toxicol. In Vitro 2024, 94, 105728. 37951556

Cited by

Sorted by citations

Authors
Youhanna, S., Taebnia, N., Liang, Y., Cheng, N., Wang, Y., Michel, M., & Lauschke, V. M.
Affiliations
  • Karolinska University Hospital (SE)
  • Karolinska Institutet (SE)
  • Zhejiang University (CN)
  • College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China
Corresponding author
  • Youhanna, Sonia
  • Taebnia, Nayere
  • Lauschke, Volker M.
ORCID
Venue
Advanced Biology
Publisher
Wiley
Published
2025-11-07
Volume
9
Issue
12
Pages
e00337-e00337
ISSN
2701-0198 (ISSN-L)
DOI
10.1002/adbi.202500337
PMC
PMC12712776
OpenAlex
W4415990198
Cited by
9
References
19
Citations by year
2026: 9
FWCI
1.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Biology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
Funders
  • Knut och Alice Wallenbergs Stiftelse (WASPDDLS22:006)
  • Novo Nordisk Fonden (NNF23OC0084420, NNF23OC0085944)
  • Vetenskapsrådet (2024‐03401, 2021‐02801, 2023‐03015)
  • HORIZON EUROPE European Research Council (101170408)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, organoids, multicellular spheroids, precision-cut liver slices, microphysiological systems, high-throughput drug screening, liver fibrosis, metabolic syndrome, drug development
MeSH terms
Fatty Liver, Humans, Liver, Models, Biological, Drug Discovery, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review