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Dendrimer‐Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells
Open accessAbstract
We demonstrated a unique approach that combines a layer‐by‐layer (LbL) self‐assembly method with dendrimer chemistry to functionalize Fe 3 O 4 nanoparticles (NPs) for specific targeting and imaging of cancer cells. In this approach, positively charged Fe 3 O 4 NPs (8.4 nm in diameter) synthesized by controlled co‐precipitation of Fe II and Fe III ions were modified with a bilayer composed of polystyrene sulfonate sodium salt and folic acid (FA)‐ and fluorescein isothiocyanate (FI)‐functionalized poly(amidoamine) dendrimers of generation 5 (G5.NH 2‐FI‐FA) through electrostatic LbL assembly, followed by an acetylation reaction to neutralize the remaining surface amine groups of G5 dendrimers. Combined flow cytometry, confocal microscopy, transmission electron microscopy, and magnetic resonance imaging studies show that Fe 3 O 4/PSS/G5.NHAc‐FI‐FA NPs can specifically target cancer cells overexpressing FA receptors. The present approach to functionalizing Fe 3 O 4 NPs opens a new avenue to fabricating various NPs for numerous biological sensing and therapeutic applications.
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de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821
Cited by
A Synergistically Enhanced T1–T2 Dual‐Modal Contrast Agent
Zhou, Z., Huang, D., Bao, J., Chen, Q., Liu, G., Chen, Z., Chen, X., & Gao, J. (2012) · Advanced Materials · doi:10.1002/adma.201203169 · Cited by 293
Recent advances in dendrimer-based nanoplatform for cancer treatment: A review
Ambekar, R. S., Choudhary, M., & Kandasubramanian, B. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109546 · Cited by 126
Multiscale observation of biological interactions of nanocarriers: From nano to macro
Jin, S., Bae, J. W., & Hong, S. (2010) · Microscopy Research and Technique · doi:10.1002/jemt.20847 · Cited by 42
Metadata
- Authors
- Wang, S. H., Shi, X., Van Antwerp, M., Cao, Z., Swanson, S. D., Bi, X., & Baker, J. R.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2007-08-31
- Volume
- 17
- Issue
- 16
- Pages
- 3043-3050
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2112329944
- Cited by
- 193
- References
- 1
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, S. H., Shi, X., Van Antwerp, M., Cao, Z., Swanson, S. D., Bi, X., & Baker, J. R. (2007). Dendrimer‐Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells. Advanced Functional Materials. https://doi.org/10.1002/adfm.200601139
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