Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
Open accessAbstract
The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. We show here that in vivo magnetic resonance tracking of magnetically labeled cells is feasible in humans for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information. Autologous dendritic cells were labeled with a clinical superparamagnetic iron oxide formulation or (111)In-oxine and were co-injected intranodally in melanoma patients under ultrasound guidance. In contrast to scintigraphic imaging, magnetic resonance imaging (MRI) allowed assessment of the accuracy of dendritic cell delivery and of inter- and intra-nodal cell migration patterns. MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans.
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Studies investigating the biological effects of typically sugar-coated SPION on dendritic cells, mesenchymal stem cells, endothelial cells and tumor cells have reported no impact on phenotype and cellular function.
“Studies investigating the biological effects of (typically sugar-coated) SPION on dendritic cells [126], mesenchymal stem cells [127, 128], endothelial cells [129, 130] and tumor cells [131] have reported no impact on phenotype and cellular function.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [126]
Both MRI and scintigraphy showed similar sensitivity for tracking dendritic cell vaccines, but misadministration could only be detected by MRI.
“Both methods showed similar sensitivity but misadministration (next to rather than into the lymph node) could only be detected by MRI [126].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [126]
Stem cells as well as immune cells such as T cells and dendritic cells have been labeled with SPION to allow for noninvasive tracking via MR imaging and to monitor in vivo delivery to the site of action.
“In this context, stem cells as well as immune cells such as T cells [259] and dendritic cells [126] have been labeled with SPION to allow for noninvasive tracking via MR imaging and to monitor in vivo delivery to the site of action [260].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [126]
The delivery of dendritic cell vaccines could be more accurately visualized and verified by MRI as compared to scintigraphy.
“The delivery of the dendritic cell vaccines could be more accurately visualized and verified by MRI as compared to scintigraphy.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [126]
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Self-citation
- Authors
- de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., Bulte, J. W. M., Scheenen, T. W. J., Punt, C. J. A., Heerschap, A., & Figdor, C. G.
- Affiliations
- Radboud University Nijmegen (NL)
- Johns Hopkins University (US)
- Corresponding author
- Bulte, Jeff W M
- Figdor, Carl G
- ORCID
- Venue
- Nature Biotechnology
- Published
- 2005-10-30
- Volume
- 23
- Issue
- 11
- Pages
- 1407-1413
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2162666572
- Cited by
- 821
- References
- 29
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 21 · 2022: 22 · 2021: 25 · 2020: 24 · 2019: 29 · 2018: 27 · 2017: 25 · 2016: 37 · 2015: 36 · 2014: 55 · 2013: 50 · 2012: 71
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5r01ns045062-10, NS 045062, RO1 NS045062)
- National Institute of Neurological Disorders and Stroke (R01-NS045062)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- dendritic cell immunotherapy, melanoma, superparamagnetic iron oxide nanoparticles, indium-111 oxine, autologous dendritic cells
- MeSH terms
- Cell Movement, Cell Separation, Dendritic Cells, Ferric Compounds, Flow Cytometry, Humans, Immunohistochemistry, Immunotherapy, Indium Radioisotopes, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Melanoma, Monocytes, Phenotype, Radionuclide Imaging, Models, Statistical, Cell Transplantation
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