The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Direct‐Write Assembly of Microperiodic Silk Fibroin Scaffolds for Tissue Engineering Applications
Abstract
Three–dimensional, microperiodic scaffolds of regenerated silk fibroin have been fabricated for tissue engineering by direct ink writing. The ink, which consisted of silk fibroin solution from the Bombyx mori silkworm, was deposited in a layer‐by‐layer fashion through a fine nozzle to produce a 3D array of silk fibers of diameter 5 µm. The extruded fibers crystallized when deposited into a methanol‐rich reservoir, retaining a pore structure necessary for media transport. The rheological properties of the silk fibroin solutions were investigated and the crystallized silk fibers were characterized for structure and mechanical properties by infrared spectroscopy and nanoindentation, respectively. The scaffolds supported human bone marrow‐derived mesenchymal stem cell (hMSC) adhesion, and growth. Cells cultured under chondrogenic conditions on these scaffolds supported enhanced chondrogenic differentiation based on increased glucosaminoglycan production compared to standard pellet culture. Our results suggest that 3D silk fibroin scaffolds may find potential application as tissue engineering constructs due to the precise control of their scaffold architecture and their biocompatibility.
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Cites
Gene expression perturbation in vitro—A growing case for three-dimensional (3D) culture systems
Birgersdotter, A., Sandberg, R., & Ernberg, I. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.009 · Cited by 591
Ghosh, S., Spagnoli, G. C., Martin, I., Ploegert, S., Demougin, P., Heberer, M., & Reschner, A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20320 · Cited by 326
Cited by
Structures, mechanical properties and applications of silk fibroin materials
Koh, L.-D., Cheng, Y., Teng, C.-P., Khin, Y.-W., Loh, X.-J., Tee, S.-Y., Low, M., Ye, E., Yu, H.-D., Zhang, Y.-W., et al. (2015) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.001 · Cited by 1,241
Roach, D. J., Yuan, C., Kuang, X., Li, V. C.-F., Blake, P., Romero, M. L., Hammel, I., Yu, K., & Qi, H. J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04401 · Cited by 319
3D bioprinting of structural proteins
Włodarczyk-Biegun, M. K., & del Campo, A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.019 · Cited by 185
Nevado, P., Lopera, A., Bezzon, V., Fulla, M. R., Palacio, J., Zaghete, M. A., Biasotto, G., Montoya, A., Rivera, J., Robledo, S. M., et al. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111013 · Cited by 71
Tan, X. H., Liu, L., Mitryashkin, A., Wang, Y., & Goh, J. C. H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00313 · Cited by 36
Metadata
- Authors
- Ghosh, S., Parker, S. T., Wang, X., Kaplan, D. L., & Lewis, J. A.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2008-07-09
- Volume
- 18
- Issue
- 13
- Pages
- 1883-1889
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2155145299
- Cited by
- 287
- References
- 2
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ghosh, S., Parker, S. T., Wang, X., Kaplan, D. L., & Lewis, J. A. (2008). Direct‐Write Assembly of Microperiodic Silk Fibroin Scaffolds for Tissue Engineering Applications. Advanced Functional Materials. https://doi.org/10.1002/adfm.200800040
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