The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Metal‐Organic‐Framework‐Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response
Abstract
Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. However, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen‐specific cytotoxic T‐lymphocyte responses. This study demonstrates for the first time the construction of metal‐organic‐framework (MOF) based vaccines by encapsulating ovalbumin (OVA) and attaching the cytosine‐phosphate‐guanine oligodeoxynucleotides (CpG ODNs) in/on zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles. The pH responsive decomposition feature enables the system to release the protein antigens and CpG ODNs in the same antigen presenting cells more efficiently. More importantly, in addition to the induction of a potent immune memory response, both in vitro and in vivo experiments show that the vaccines can induce strong humoral and cellular immunity. These findings suggest that the MOF‐based vaccine platforms can be used to produce effective vaccines against a range of ailments, which will facilitate the application of MOFs in biomedical areas.
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He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
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Self-citationDNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy
Wang, H., Chen, Y., Wang, H., Liu, X., Zhou, X., & Wang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201902714 · Cited by 417
Self-citationZhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy
Zhang, J., Lin, Y., Lin, Z., Wei, Q., Qian, J., Ruan, R., Jiang, X., Hou, L., Song, J., Ding, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103444 · Cited by 292
Metadata
- Authors
- Zhang, Y., Wang, F., Ju, E., Liu, Z., Chen, Z., Ren, J., & Qu, X.
- Venue
- Advanced Functional Materials
- Publisher
- Wiley
- Published
- 2016-07-19
- Volume
- 26
- Issue
- 35
- Pages
- 6454-6461
- ISSN
- 1616-301X (ISSN-L)
- 1616-3028
- OpenAlex
- W2489311626
- Cited by
- 252
- References
- 1
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, Y., Wang, F., Ju, E., Liu, Z., Chen, Z., Ren, J., & Qu, X. (2016). Metal‐Organic‐Framework‐Based Vaccine Platforms for Enhanced Systemic Immune and Memory Response. Advanced Functional Materials. https://doi.org/10.1002/adfm.201600650
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