The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy
Abstract
DNAzymes have been recognized as potent therapeutic agents for gene therapy, while their inefficient intracellular delivery and insufficient cofactor supply precludes their practical biological applications. Metal–organic frameworks (MOFs) have emerged as promising drug carriers without in‐depth consideration of their disassembled ingredients. Herein, we report a self‐sufficient MOF‐based chlorin e6‐modified DNAzyme (Ce6‐DNAzyme) therapeutic nanosystem for combined gene therapy and photodynamic therapy (PDT). The ZIF‐8 nanoparticles (NPs) could efficiently deliver the therapeutic DNAzyme without degradation into cancer cells. The pH‐responsive ZIF‐8 NPs disassemble with the concomitant release of the guest DNAzyme payloads and the host Zn 2+ ions that serve, respectively, as messenger RNA‐targeting agent and required DNAzyme cofactors for activating gene therapy. The auxiliary photosensitizer Ce6 could produce reactive oxygen species (ROS) and provide a fluorescence signal for the imaging‐guided gene therapy/PDT.
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Cited by
Li, D., Yadav, A., Zhou, H., Roy, K., Thanasekaran, P., & Lee, C. (2024) · Global Challenges · doi:10.1002/gch2.202300244 · Cited by 437
Zhou, Z., Vázquez-González, M., & Willner, I. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01030h · Cited by 308
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Cai, M., Yao, Y., Yin, D., Zhu, R., Fu, T., Kong, J., Wang, K., Liu, J., Yao, A., Ruan, Y., et al. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.126 · Cited by 45
Metadata
- Authors
- Wang, H., Chen, Y., Wang, H., Liu, X., Zhou, X., & Wang, F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-04-25
- Volume
- 58
- Issue
- 22
- Pages
- 7380-7384
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2923284444
- Cited by
- 417
- References
- 43
- FWCI
- 18.91
- Type
- journal article
- Language
- en
- Open access
- closed
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